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Arpc2
Gene Detail
 Symbol
Name
ID
Arpc2
actin related protein 2/3 complex, subunit 2
MGI:1923959
Synonyms 2210023N03Rik, p34-Arc
Feature Type protein coding gene
Genetic Map
Chromosome 1
38.49 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:74236084-74268209 bp, + strand
From VEGA annotation of GRCm38

  32126 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4187  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: Actin-related protein 2/3 complex subunit 2
Gene Tree: Arpc2

Human
homologs
Human Homolog ARPC2, actin related protein 2/3 complex, subunit 2, 34kDa
NCBI Gene ID 10109
neXtProt AC  NX_O15144
Human Synonyms  ARC34, p34-Arc, PNAS-139
Human Chr (Location)  2q36.1; chr2:218217094-218254348 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(73) : Gene trapped(70) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Arpc2 interacts with 116 markers (Mir1a-1, Mir1a-2, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process Arp2/3 complex-mediated actin nucleation, positive regulation of actin filament polymerization, ...
Component actin cytoskeleton, Arp2/3 protein complex, ...
Function actin binding, actin filament binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (4)    Tissues (1)    Images (6)
Theiler Stages: 17
Assay TypeResults
Immunohistochemistry 4
cDNA source data(231)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(232) cDNA(232)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000016449 (Evidence)
Ensembl Gene ModelENSMUSG00000006304 (Evidence)
Entrez Gene76709 (Evidence)
UniGene337038
DFCITC1584161, TC1706495, TC1734643
DoTSDT.101200628, DT.101382715, DT.110549266, DT.496614, DT.94237560
NIA Mouse Gene IndexU000441
Consensus CDS ProjectCCDS35612.1
International Mouse Knockout Project StatusArpc2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016449 VEGA Gene Model | MGI Sequence Detail 32126 C57BL/6J ±  kb
transcript OTTMUST00000039637 VEGA | MGI Sequence Detail 1439 Not Applicable 
polypeptide OTTMUSP00000017692 VEGA | MGI Sequence Detail 300 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(4) UniProt(4)
Polymorphisms SNPs within 2kb(225 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007188 ARP2/3 complex, 34kDa subunit (p34-Arc)
Protein Ontology PR:000004310 actin-related protein 2/3 complex subunit 2
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:185589 Maritzen T, et al., Gadkin negatively regulates cell spreading and motility via sequestration of the actin-nucleating ARP2/3 complex. Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10382-7
All references(45)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory