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Arpc2 Gene Detail
Summary
  • Symbol
    Arpc2
  • Name
    actin related protein 2/3 complex, subunit 2
  • Synonyms
    2210023N03Rik, p34-Arc
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923959
    NCBI Gene: 76709
  • Gene Overview
    MyGene.info: ARPC2
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:74236505-74268213 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 38.49 cM, cytoband C3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    224 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923959
protein coding gene Chr1:74236084-74268213 (.)
129S1/SvImJ MGP_129S1SvImJ_G0016143
protein coding gene Chr1:74821391-74856161 (+)
A/J MGP_AJ_G0016126
protein coding gene Chr1:72202006-72235267 (+)
AKR/J MGP_AKRJ_G0016083
protein coding gene Chr1:74214919-74246933 (+)
BALB/cJ MGP_BALBcJ_G0016081
protein coding gene Chr1:72275887-72308384 (+)
C3H/HeJ MGP_C3HHeJ_G0015912
protein coding gene Chr1:74540136-74574629 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016534
protein coding gene Chr1:77731682-77763634 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014255
protein coding gene Chr1:67786419-67819326 (+)
CAST/EiJ MGP_CASTEiJ_G0015496
protein coding gene Chr1:73851993-73886352 (+)
CBA/J MGP_CBAJ_G0015885
protein coding gene Chr1:80249004-80284548 (+)
DBA/2J MGP_DBA2J_G0015986
protein coding gene Chr1:71540688-71572422 (+)
FVB/NJ MGP_FVBNJ_G0015989
protein coding gene Chr1:70713404-70746535 (+)
LP/J MGP_LPJ_G0016058
protein coding gene Chr1:75924543-75957322 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016009
protein coding gene Chr1:83672583-83705546 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016581
protein coding gene Chr1:74270021-74304629 (+)
PWK/PhJ MGP_PWKPhJ_G0015283
protein coding gene Chr1:70981235-71014723 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015061
protein coding gene Chr1:73634551-73669255 (+)
WSB/EiJ MGP_WSBEiJ_G0015558
protein coding gene Chr1:74073734-74108327 (+)



Homology
more
  • Human Ortholog
    ARPC2, actin related protein 2/3 complex subunit 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ARPC2, actin related protein 2/3 complex subunit 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ARC34, p34-Arc, PNAS-139, PRO2446
  • Links
    NCBI Gene ID: 10109
    neXtProt AC: NX_O15144
    UniProt: O15144

  • Chr Location
    2q35; chr2:218217094-218254348 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 76709 NCBI Gene Model | MGI Sequence Detail 31709 C57BL/6J ±  kb
    transcript NM_029711 RefSeq | MGI Sequence Detail 1643 C57BL/6  
    polypeptide Q9CVB6 UniProt | EBI | MGI Sequence Detail 300 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 234
      cDNA 234

      Microarray probesets 3
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 3
      Gene Ontology 11
      Phenotypes 20
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:265040 Zhang Y, et al., Arp2/3 complex controls T cell homeostasis by maintaining surface TCR levels via regulating TCR(+) endosome trafficking. Sci Rep. 2017 Aug 21;7(1):8952

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory