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Ctrc
Gene Detail
Symbol

Name
ID
Ctrc
chymotrypsin C (caldecrin)
MGI:1923951
Synonyms
1810044E12Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 4
74.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr4:141814962-141846357 bp, - strand
From VEGA annotation of GRCm38

  31396 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21422  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 2 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: CTRC
Protein SuperFamily: trypsin
Gene Tree: Ctrc

Human
homologs
CTRC, chymotrypsin C (caldecrin)
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 11330
neXtProt AC: NX_Q99895

Human Synonyms: CLCR, ELA4

Human Chr (Location): 1p36.21; chr1:15438442-15449247 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CTRC

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Genomic Mutations involving Ctrc (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Ctrc interacts with 20 markers (Mir101a, Mir138-2, Mir139, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process cellular calcium ion homeostasis, proteolysis
Component cell
Function hydrolase activity, peptidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(88)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ctrc    NEW 
Molecular
reagents
All nucleic(88) cDNA(88)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000010017 (Evidence)
Ensembl Gene Model ENSMUSG00000062478 (Evidence)
Entrez Gene 76701 (Evidence)
UniGene 489680
DFCI TC1579048, TC1663096
DoTS DT.94241474, DT.101255316
EC 3.4.21.2
International Mouse Phenotyping Consortium Status Ctrc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010017 VEGA Gene Model | MGI Sequence Detail 31396 C57BL/6J ±  kb
transcript OTTMUST00000023292 VEGA | MGI Sequence Detail 784 Not Applicable 
polypeptide OTTMUSP00000010650 VEGA | MGI Sequence Detail 235 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(2) UniProt(4)
Polymorphisms
SNPs within 2kb(853 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000006020 chymotrypsin-C
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:214089 Hale MA, et al., The nuclear hormone receptor family member NR5A2 controls aspects of multipotent progenitor cell formation and acinar differentiation during pancreatic organogenesis. Development. 2014 Aug;141(16):3123-33
All references(24)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory