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Spcs3 Gene Detail
Summary
  • Symbol
    Spcs3
  • Name
    signal peptidase complex subunit 3 homolog (S. cerevisiae)
  • Synonyms
    1810011E08Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923937
    NCBI Gene: 76687
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:54520433-54529998 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 29.26 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    98 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923937
protein coding gene Chr8:54520433-54530751 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033611
protein coding gene Chr8:54174183-54183718 (-)
A/J MGP_AJ_G0033593
protein coding gene Chr8:51903444-51912979 (-)
AKR/J MGP_AKRJ_G0033518
protein coding gene Chr8:53380175-53389740 (-)
BALB/cJ MGP_BALBcJ_G0033590
protein coding gene Chr8:52130936-52140501 (-)
C3H/HeJ MGP_C3HHeJ_G0033299
protein coding gene Chr8:54071473-54081038 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034106
protein coding gene Chr8:56191270-56200835 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031054
protein coding gene Chr8:47735743-47745357 (-)
CAST/EiJ MGP_CASTEiJ_G0032625
protein coding gene Chr8:53694629-53704212 (-)
CBA/J MGP_CBAJ_G0033278
protein coding gene Chr8:58247885-58257420 (-)
DBA/2J MGP_DBA2J_G0033431
protein coding gene Chr8:51703155-51714156 (-)
FVB/NJ MGP_FVBNJ_G0033372
protein coding gene Chr8:51044578-51054144 (-)
LP/J MGP_LPJ_G0033519
protein coding gene Chr8:54164670-54174235 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033416
protein coding gene Chr8:59458336-59467901 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034124
protein coding gene Chr8:53665890-53675425 (-)
PWK/PhJ MGP_PWKPhJ_G0032333
protein coding gene Chr8:51241989-51251596 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032169
protein coding gene Chr8:52753959-52763546 (-)
WSB/EiJ MGP_WSBEiJ_G0032741
protein coding gene Chr8:53909442-53919032 (-)



Homology
more
  • Human Ortholog
    SPCS3, signal peptidase complex subunit 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SPCS3, signal peptidase complex subunit 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PRO3567, SPC22/23, SPC3, YLR066W
  • Links
    NCBI Gene ID: 60559
    neXtProt AC: NX_P61009
    UniProt: P61009

  • Chr Location
    4q34.2; chr4:176319939-176332245 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000054408 Ensembl Gene Model | MGI Sequence Detail 9566 C57BL/6J ±  kb
transcript ENSMUST00000067476 Ensembl | MGI Sequence Detail 3466 Not Applicable  
polypeptide ENSMUSP00000136527 Ensembl | MGI Sequence Detail 180 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 104
    cDNA 103
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 29
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 7
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory