Wfdc3 MGI Mouse Gene Detail - MGI:1923897 - WAP four-disulfide core domain 3

Symbol

Wfdc3
Name

WAP four-disulfide core domain 3
Synonyms

1700015L13Rik, 1700127F16Rik

Feature Type

protein coding gene
IDs

MGI:1923897
NCBI Gene: 71856
Alliance

genome feature page
Transcription Start Sites

7 TSS

Sequence Map

Chr2:164573222-164587914 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 85.27 cM, cytoband H3
Mapping Data

4 experiments

SNPs within 2kb

483 from dbSNP Build 142
Strain Annotations

25

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1923897	protein coding gene	Chr2:164573100-164587914 (-)
129S1/SvImJ	ENSMUSG00200016742	protein coding gene	Chr2:161462159-161476917 (-)
A/J	ENSMUSG00195023782	protein coding gene	Chr2:161806590-161808962 (-)
A/J	ENSMUSG00195023774	protein coding gene	Chr2:161794204-161808963 (-)
AKR/J	ENSMUSG00220013069	protein coding gene	Chr2:161123669-161138414 (-)
AKR/J	ENSMUSG00220013077	protein coding gene	Chr2:161136041-161138413 (-)
BALB/cJ	ENSMUSG00180048108	protein coding gene	Chr2:161247918-161262673 (-)
BALB/cJ	ENSMUSG00180048132	protein coding gene	Chr2:161260300-161262672 (-)
C3H/HeJ	ENSMUSG00175048718	protein coding gene	Chr2:161998474-162013235 (-)
C57BL/6NJ	ENSMUSG00215027475	protein coding gene	Chr2:161458375-161460747 (-)
C57BL/6NJ	ENSMUSG00215027416	protein coding gene	Chr2:161445997-161460748 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024663	protein coding gene	Chr2:156676386-156691939 (-)
CAST/EiJ	ENSTCUG00005044792	protein coding gene	Chr2:160365496-160380085 (-)
CBA/J	ENSMUSG00210015891	protein coding gene	Chr2:161928573-161943330 (-)
CBA/J	ENSMUSG00210015906	protein coding gene	Chr2:161940957-161943329 (-)
DBA/2J	ENSMUSG00185044652	protein coding gene	Chr2:161665616-161680387 (-)
FVB/NJ	ENSMUSG00205026185	protein coding gene	Chr2:160686497-160701264 (-)
JF1/MsJ	ENSUMUG00000029239	protein coding gene	Chr2:161305709-161320588 (-)
LP/J	ENSMUSG00230039532	protein coding gene	Chr2:163223263-163238015 (-)
NOD/ShiLtJ	ENSMUSG00190028320	protein coding gene	Chr2:161345811-161348183 (-)
NOD/ShiLtJ	ENSMUSG00190028248	protein coding gene	Chr2:161333427-161348184 (-)
NZO/HlLtJ	ENSMUSG00225050766	protein coding gene	Chr2:171227947-171242714 (-)
PWK/PhJ	ENSLUMG00010045831	protein coding gene	Chr2:161207995-161223320 (-)
SPRET/EiJ	ENSMSPG00010025693	protein coding gene	Chr2:163971536-163983387 (-)
WSB/EiJ	ENSIUOG00005042741	protein coding gene	Chr2:161054470-161069220 (-)

Human Ortholog

WFDC3, WAP four-disulfide core domain 3

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

WFDC3, WAP four-disulfide core domain 3
Synonyms

dJ447F3.3, WAP14
Links

HGNC:15957

NCBI Gene ID: 140686

UniProt: Q8IUB2
Chr Location

20q13.12; chr20:45747944-45791932 (-) GRCh38

MGI Vertebrate Homology

Wfdc3 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: WFDC3
Gene Tree

Wfdc3

less

Phenotype Summary

7 phenotype references

All Mutations and Alleles

7
Endonuclease-mediated

3
Gene trapped

1
Targeted

3
Incidental Mutations

APF
Find Mice (IMSR)

13 strains or lines available

less

All GO Annotations

7
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

614
Tissues

14
cDNA Data

6
Literature Summary

3

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

less

All Sequences

54
RefSeq

14
UniProt

3
CCDS

CCDS17053.1

Ensembl

ENSMUSG00000076434 (Evidence)
NCBI Gene

71856

			Length	Strain/Species	Flank
genomic	71856	NCBI Gene Model \| MGI Sequence Detail	14693	C57BL/6J	± kb
transcript	NR_184810	RefSeq \| MGI Sequence Detail	1631	C57BL/6
polypeptide	Q14AE4	UniProt \| EBI \| MGI Sequence Detail	130	Not Applicable

less

UniProt

3 Sequences
InterPro Domains

IPR036645 Elafin-like superfamily

IPR050514 WAP four-disulfide core domain

IPR008197 WAP-type 'four-disulfide core' domain
GlyGen

Q14AE4 1 site

less

All nucleic 8

cDNA 6

Primer pair 2

Microarray probesets 3

less

MGI:1919106

Summaries

All 33

Developmental Gene Expression 3

Gene Ontology 3

Phenotypes 7
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:326355 Bademci G, et al., Mutations in MINAR2 encoding membrane integral NOTCH2-associated receptor 2 cause deafness in humans and mice. Proc Natl Acad Sci U S A. 2022 Jun 28;119(26):e2204084119

TSS for Wfdc3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr27528	Chr2:164587836-164587860 (-)	66 bp
Tssr27527	Chr2:164587816-164587834 (-)	89 bp
Tssr27526	Chr2:164585102-164585131 (-)	2,797 bp
Tssr27525	Chr2:164585075-164585101 (-)	2,826 bp
Tssr27524	Chr2:164585052-164585067 (-)	2,854 bp
Tssr27523	Chr2:164585033-164585044 (-)	2,875 bp
Tssr27522	Chr2:164585019-164585028 (-)	2,890 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24