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Hectd3 Gene Detail
Summary
  • Symbol
    Hectd3
  • Name
    HECT domain E3 ubiquitin protein ligase 3
  • Synonyms
    1700064K09Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923858
    NCBI Gene: 76608
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:116995317-117005277 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 53.41 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    54 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923858
protein coding gene Chr4:116995294-117005277 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028640
protein coding gene Chr4:117943820-117954549 (+)
A/J MGP_AJ_G0028601
protein coding gene Chr4:113398756-113409473 (+)
AKR/J MGP_AKRJ_G0028551
protein coding gene Chr4:115875856-115887280 (+)
BALB/cJ MGP_BALBcJ_G0028622
protein coding gene Chr4:114028742-114039126 (+)
C3H/HeJ MGP_C3HHeJ_G0028336
protein coding gene Chr4:117438171-117449017 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029063
protein coding gene Chr4:122487694-122502823 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026347
protein coding gene Chr4:107446334-107456782 (+)
CAST/EiJ MGP_CASTEiJ_G0027770
protein coding gene Chr4:114657700-114668245 (+)
CBA/J MGP_CBAJ_G0028303
protein coding gene Chr4:125837546-125847203 (+)
DBA/2J MGP_DBA2J_G0028451
protein coding gene Chr4:114035200-114045287 (+)
FVB/NJ MGP_FVBNJ_G0028419
protein coding gene Chr4:112538091-112548074 (+)
LP/J MGP_LPJ_G0028553
protein coding gene Chr4:118125049-118136186 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028446
protein coding gene Chr4:130791634-130802400 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029100
protein coding gene Chr4:117022833-117032671 (+)
PWK/PhJ MGP_PWKPhJ_G0027496
protein coding gene Chr4:110821231-110831594 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027319
protein coding gene Chr4:113314306-113324353 (+)
WSB/EiJ MGP_WSBEiJ_G0027849
protein coding gene Chr4:116891478-116901873 (+)



Homology
more
  • Human Ortholog
    HECTD3, HECT domain E3 ubiquitin protein ligase 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HECTD3, HECT domain E3 ubiquitin protein ligase 3
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 79654
    neXtProt AC: NX_Q5T447
    UniProt: Q5T447

  • Chr Location
    1p34.1; chr1:45002548-45011355 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 18426
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: HECTD3
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased susceptibility to intranasal bacterial infection due to suppressed bacterial intracellular replication.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000046861 Ensembl Gene Model | MGI Sequence Detail 9961 C57BL/6J ±  kb
transcript ENSMUST00000050067 Ensembl | MGI Sequence Detail 4583 Not Applicable  
polypeptide ENSMUSP00000051922 Ensembl | MGI Sequence Detail 861 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 13
    cDNA 13

    Microarray probesets 5
Other
Accession IDs
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MGI:2140305, MGI:2140618
References
more
  • Summaries
    All 34
    Gene Ontology 3
    Phenotypes 12
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:266602 Li F, et al., HECTD3 mediates TRAF3 polyubiquitination and type I interferon induction during bacterial infection. J Clin Invest. 2018 Aug 31;128(9):4148-4162

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory