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Gtf2f1
Gene Detail
 Symbol
Name
ID
Gtf2f1
general transcription factor IIF, polypeptide 1
MGI:1923848
Synonyms 2810405L04Rik
Feature Type protein coding gene
Genetic Map
Chromosome 17
29.62 cM, cytoband E1.1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr17:57003405-57011288 bp, - strand
From Ensembl annotation of GRCm38

  7884 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1585  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Gtf2f1

Human
homologs
Human Homolog GTF2F1, general transcription factor IIF, polypeptide 1, 74kDa
NCBI Gene ID 2962
neXtProt AC  NX_P35269
Human Synonyms  BTF4, RAP74, TF2F1, TFIIF
Human Chr (Location)  19p13.3; chr19:6379569-6393280 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Gene trapped(15) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Gtf2f1 interacts with 9 markers (Mir133a-1, Mir133a-2, Mir207, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process positive regulation of catalytic activity, positive regulation of transcription elongation from RNA polymerase II promoter, ...
Component cell junction, nucleus
Function catalytic activity, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (60)    Tissues (44)    Images (7)
Theiler Stages: 17, 20, 23
Assay TypeResults
RNA in situ 60
cDNA source data(96)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(96) cDNA(96)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000002658 (Evidence)
Entrez Gene98053 (Evidence)
UniGene24632
DFCITC1574826
DoTSDT.528285, DT.94259589
Consensus CDS ProjectCCDS37667.1
International Mouse Knockout Project StatusGtf2f1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000002658 Ensembl Gene Model | MGI Sequence Detail 7884 C57BL/6J ±  kb
transcript ENSMUST00000002733 Ensembl | MGI Sequence Detail 1717 Not Applicable 
polypeptide ENSMUSP00000002733 Ensembl | MGI Sequence Detail 508 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(4) UniProt(3)
Polymorphisms SNPs within 2kb(72 from dbSNP Build 137)    SNPs within 2kb including multiple locations(74)
Protein-related
information
ResourceIDDescription
InterPro IPR011039 Transcription Factor IIF, Rap30/Rap74, interaction
InterPro IPR008851 Transcription initiation factor IIF, alpha subunit
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000008315 general transcription factor IIF subunit 1
References (Earliest) J:42570 Newberry EP, et al., Structure-function analysis of Msx2-mediated transcriptional suppression. Biochemistry. 1997 Aug 26;36(34):10451-62
(Latest) J:181994 Kamileri I, et al., Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria. Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2995-3000
All references(36)
Other
accession IDs
MGI:2147115

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory