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Wipi2 Gene Detail
Summary
  • Symbol
    Wipi2
  • Name
    WD repeat domain, phosphoinositide interacting 2
  • Synonyms
    1110018O08Rik, 2510001I10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923831
    NCBI Gene: 74781
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:142615269-142655427 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 5, 81.53 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    88 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923831
protein coding gene Chr5:142613453-142656343 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030315
protein coding gene Chr5:147882803-147926537 (+)
A/J MGP_AJ_G0030284
protein coding gene Chr5:141544727-141589483 (+)
AKR/J MGP_AKRJ_G0030216
protein coding gene Chr5:145956913-146002267 (+)
BALB/cJ MGP_BALBcJ_G0030301
protein coding gene Chr5:142792369-142835737 (+)
C3H/HeJ MGP_C3HHeJ_G0030012
protein coding gene Chr5:146783207-146830257 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030746
protein coding gene Chr5:153295331-153339112 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027964
protein coding gene Chr5:135365678-135407903 (+)
CAST/EiJ MGP_CASTEiJ_G0029417
protein coding gene Chr5:146240575-146292408 (+)
CBA/J MGP_CBAJ_G0029982
protein coding gene Chr5:159567348-159613923 (+)
DBA/2J MGP_DBA2J_G0030132
protein coding gene Chr5:141318288-141362072 (+)
FVB/NJ MGP_FVBNJ_G0030087
protein coding gene Chr5:140511402-140553905 (+)
LP/J MGP_LPJ_G0030218
protein coding gene Chr5:148493804-148545972 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030118
protein coding gene Chr5:162061026-162107953 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030786
protein coding gene Chr5:145810426-145857573 (+)
PWK/PhJ MGP_PWKPhJ_G0029132
protein coding gene Chr5:140390667-140436026 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028968
protein coding gene Chr5:143553573-143606841 (+)
WSB/EiJ MGP_WSBEiJ_G0029491
protein coding gene Chr5:146613784-146658388 (+)



Homology
more
  • Human Ortholog
    WIPI2, WD repeat domain, phosphoinositide interacting 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WIPI2, WD repeat domain, phosphoinositide interacting 2
  • Synonyms
    ATG18B, Atg21, CGI-50, IDDSSA, WIPI-2
  • Links
    NCBI Gene ID: 26100
    neXtProt AC: NX_Q9Y4P8
    UniProt: Q9Y4P8

  • Chr Location
    7p22.1; chr7:5190196-5233855 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 74781 NCBI Gene Model | MGI Sequence Detail 40159 C57BL/6J ±  kb
    transcript NM_178398 RefSeq | MGI Sequence Detail 3942 C57BL/6  
    polypeptide Q80W47 UniProt | EBI | MGI Sequence Detail 445 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 176
      cDNA 176

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1922031
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 4
      Gene Ontology 5
      Phenotypes 8
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:312370 Zhao Y, et al., GLIPR2 is a negative regulator of autophagy and the BECN1-ATG14-containing phosphatidylinositol 3-kinase complex. Autophagy. 2021 Oct;17(10):2891-2904

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory