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Tbata Gene Detail
Summary
  • Symbol
    Tbata
  • Name
    thymus, brain and testes associated
  • Synonyms
    1700021K02Rik, Spatial
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923820
    NCBI Gene: 65971
Location & Maps
more
  • Sequence Map
    Chr10:61171954-61188841 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      16888 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 32.16 cM, cytoband B3-B4
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    TBATA, thymus, brain and testes associated
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TBATA, thymus, brain and testes associated
    Orthology source: HGNC, HomoloGene
  • Synonyms
    C10orf27, SPATIAL
  • Links
    NCBI Gene ID: 219793
    neXtProt AC: NX_Q96M53

  • Chr Location
    10q22.1; chr10:70771238-70785401 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Gene trapped
    2
  • Radiation induced
    1
  • Targeted
    1
  • Genomic Mutations
    2 involving Tbata
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit increased thymic pithelial cells and total thymocyte numbers without altering T cell development and function.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031951 VEGA Gene Model | MGI Sequence Detail 16888 C57BL/6J ±  kb
transcript OTTMUST00000079277 VEGA | MGI Sequence Detail 1506 Not Applicable  
polypeptide OTTMUSP00000042270 VEGA | MGI Sequence Detail 393 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    66 from dbSNP Build 142
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000015499 protein SPATIAL
Molecular
Reagents
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  • All nucleic 18
    cDNA 15
    Primer pair 2
    Other 1

    Microarray probesets 8
Other
Accession IDs
less
MGI:2143597
References
more
  • Summaries
    All 31
    Developmental Gene Expression 5
    Gene Ontology 4
    Phenotypes 9
  • Earliest
    J:102265 Flomerfelt FA, et al., Spatial, a gene expressed in thymic stromal cells, depends on three-dimensional thymus organization for its expression. Genes Immun. 2000 Aug;1(6):391-401
  • Latest
    J:166065 Flomerfelt FA, et al., Tbata modulates thymic stromal cell proliferation and thymus function. J Exp Med. 2010 Oct 25;207(11):2521-32

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory