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Prss8 Gene Detail
Summary
  • Symbol
    Prss8
  • Name
    protease, serine 8 (prostasin)
  • Synonyms
    2410039E18Rik, CAP1, fr, mCAP1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923810
    NCBI Gene: 76560
  • Gene Overview
    MyGene.info: PRSS8
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr7:127925716-127930104 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4389 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 69.84 cM
  • Mapping Data
    17 experiments
Homology
more
  • Human Ortholog
    PRSS8, serine protease 8
  • Vertebrate Orthologs
    8
  • Human Ortholog
    PRSS8, serine protease 8
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CAP1, PROSTASIN
  • Links
    NCBI Gene ID: 5652
    neXtProt AC: NX_Q16651
    UniProt: Q16651

  • Chr Location
    16p11.2; chr16:31131433-31135762 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Prss8 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    42 phenotypes from 7 alleles in 6 genetic backgrounds
    11 phenotypes from multigenic genotypes
    2 images
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mutations result in impaired skin barrier function, dehydration, and postnatal lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000058635 VEGA Gene Model | MGI Sequence Detail 4389 C57BL/6J ±  kb
    transcript OTTMUST00000143990 VEGA | MGI Sequence Detail 1852 Not Applicable  
    polypeptide OTTMUSP00000075075 VEGA | MGI Sequence Detail 339 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      108 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • EC
    • InterPro Domains
      IPR001314 Peptidase S1A, chymotrypsin family
      IPR009003 Peptidase S1, PA clan
      IPR001254 Serine proteases, trypsin domain
      IPR018114 Serine proteases, trypsin family, histidine active site
      IPR033116 Serine proteases, trypsin family, serine active site
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 9
      Primer pair 1
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-9870, MGI:2141897, MGI:2142334, MGI:95577
    References
    more
    • Summaries
      All 79
      Developmental Gene Expression 11
      Diseases 1
      Gene Ontology 8
      Phenotypes 28
    • Earliest
      J:92 Falconer DS, et al., Two new hair mutants, rough and frizzy in the house mouse. J Hered. 1952;43:53-57
    • Latest
      J:245888 Buzza MS, et al., Inflammatory cytokines down-regulate the barrier-protective prostasin-matriptase proteolytic cascade early in experimental colitis. J Biol Chem. 2017 Jun 30;292(26):10801-10812

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory