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Prss8 Gene Detail
Summary
  • Symbol
    Prss8
  • Name
    protease, serine 8 (prostasin)
  • Synonyms
    2410039E18Rik, CAP1, fr, mCAP1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923810
    NCBI Gene: 76560
  • Gene Overview
    MyGene.info: PRSS8
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:127925716-127930104 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 69.84 cM
  • Mapping Data
    17 experiments
Strain
Comparison
more
  • SNPs within 2kb
    108 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923810
protein coding gene Chr7:127925716-127930149 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033065
protein coding gene Chr7:132315249-132319637 (-)
A/J MGP_AJ_G0033048
protein coding gene Chr7:128771235-128775623 (-)
AKR/J MGP_AKRJ_G0032980
protein coding gene Chr7:132105191-132109578 (-)
BALB/cJ MGP_BALBcJ_G0033049
protein coding gene Chr7:128427404-128431791 (-)
C3H/HeJ MGP_C3HHeJ_G0032763
protein coding gene Chr7:132006936-132011323 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033558
protein coding gene Chr7:137463628-137468016 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030531
protein coding gene Chr7:129959102-129963379 (-)
CAST/EiJ MGP_CASTEiJ_G0032092
protein coding gene Chr7:123800232-123804650 (-)
CBA/J MGP_CBAJ_G0032736
protein coding gene Chr7:142134053-142138441 (-)
DBA/2J MGP_DBA2J_G0032888
protein coding gene Chr7:126747015-126751403 (-)
FVB/NJ MGP_FVBNJ_G0032841
protein coding gene Chr7:126609184-126613572 (-)
LP/J MGP_LPJ_G0032982
protein coding gene Chr7:133782295-133786683 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032873
protein coding gene Chr7:143199332-143203720 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033578
protein coding gene Chr7:131089541-131095629 (-)
PWK/PhJ MGP_PWKPhJ_G0031799
protein coding gene Chr7:119755374-119759772 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031645
protein coding gene Chr7:117900244-117904676 (-)
WSB/EiJ MGP_WSBEiJ_G0032204
protein coding gene Chr7:132054715-132059103 (-)



Homology
more
  • Human Ortholog
    PRSS8, serine protease 8
  • Vertebrate Orthologs
    8
  • Human Ortholog
    PRSS8, serine protease 8
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CAP1, PROSTASIN
  • Links
    NCBI Gene ID: 5652
    neXtProt AC: NX_Q16651
    UniProt: Q16651

  • Chr Location
    16p11.2; chr16:31131433-31135762 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Prss8 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    43 phenotypes from 7 alleles in 6 genetic backgrounds
    12 phenotypes from multigenic genotypes
    2 images
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Nullizygous mutations result in impaired skin barrier function, dehydration, and postnatal lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030800 Ensembl Gene Model | MGI Sequence Detail 4389 C57BL/6J ±  kb
    transcript ENSMUST00000206124 Ensembl | MGI Sequence Detail 1709 Not Applicable  
    polypeptide ENSMUSP00000145904 Ensembl | MGI Sequence Detail 339 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • EC
    • InterPro Domains
      IPR001314 Peptidase S1A, chymotrypsin family
      IPR009003 Peptidase S1, PA clan
      IPR001254 Serine proteases, trypsin domain
      IPR018114 Serine proteases, trypsin family, histidine active site
      IPR033116 Serine proteases, trypsin family, serine active site
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 10
      Primer pair 2
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-9870, MGI:2141897, MGI:2142334, MGI:95577
    References
    more
    • Summaries
      All 81
      Developmental Gene Expression 12
      Diseases 1
      Gene Ontology 9
      Phenotypes 28
    • Earliest
      J:92 Falconer DS, et al., Two new hair mutants, rough and frizzy in the house mouse. J Hered. 1952;43:53-57
    • Latest
      J:261068 Szabo R, et al., Loss of HAI-2 in mice with decreased prostasin activity leads to an early-onset intestinal failure resembling congenital tufting enteropathy. PLoS One. 2018;13(4):e0194660

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory