Prss8
Gene Detail

Symbol Name ID

Prss8 protease, serine, 8 (prostasin) MGI:1923810

Synonyms

2410039E18Rik, CAP1, fr, mCAP1

Feature Type

protein coding gene

Genetic Map

Chromosome 7

69.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(17)

Sequence Map

Chr7:127925725-127930113 bp, - strand From Ensembl annotation of GRCm38   4389 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20613  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 2 zebrafish

Protein SuperFamily: trypsin
Gene Tree: Prss8

Human homologs

Human Homolog		PRSS8, protease, serine, 8
NCBI Gene ID		5652
neXtProt AC		NX_Q16651
Human Synonyms		CAP1, PROSTASIN
Human Chr (Location)		16p11.2; chr16:31142754-31147151 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(10) : Targeted(5) Gene trapped(4) Spontaneous(1)
 

Mutations in this gene result in abnormal vibrissae and coat growth.

 
Human Diseases Modeled Using Mouse Prss8 (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (21 annotations)

Process	hair follicle development, positive regulation of sodium ion transport, ...
Component	anchored to plasma membrane, extracellular region, ...
Function	catalytic activity, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (193)    Tissues (81)    Images (25)
Theiler Stages: 14, 23, 28

Assay Type	Results
RNA in situ	147
RT-PCR	46

cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(11) cDNA(9) Primer pair(1) Other(1)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000030800 (Evidence)
Entrez Gene	76560 (Evidence)
EC	3.4.21.-
Consensus CDS Project	CCDS40147.1
International Mouse Knockout Project Status	Prss8

Sequences

Length	Strain/Species
genomic	ENSMUSG00000030800	Ensembl Gene Model | MGI Sequence Detail	4389	C57BL/6J
transcript	ENSMUST00000032988	Ensembl | MGI Sequence Detail	1852	Not Applicable
polypeptide	ENSMUSP00000032988	Ensembl | MGI Sequence Detail	339	Not Applicable

All sequences(23) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(79 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR009003	Peptidase cysteine/serine, trypsin-like
InterPro	IPR001314	Peptidase S1A, chymotrypsin-type
InterPro	IPR001254	Peptidase S1/S6, chymotrypsin/Hap
InterPro	IPR018114	Peptidase S1/S6, chymotrypsin/Hap, active site
Protein Ontology	PR:000013330	prostasin

References

(Earliest) J:64269 Snell GD, fr - frizzy. Mouse News Lett. 1951;5:36
(Latest) J:188121 Szabo R, et al., Reduced Prostasin (CAP1/PRSS8) Activity Eliminates HAI-1 and HAI-2 Deficiency-Associated Developmental Defects by Preventing Matriptase Activation. PLoS Genet. 2012 Aug;8(8):e1002937
All references(59)

Other accession IDs

MGD-MRK-9870, MGI:2141897, MGI:2142334, MGI:95577