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Prss8
Gene Detail
Symbol

Name
ID
Prss8
protease, serine 8 (prostasin)
MGI:1923810
Synonyms
2410039E18Rik, CAP1, fr, mCAP1
Feature Type
protein coding gene
Genetic Map
Chromosome 7
69.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(17)
Sequence Map
Chr7:127925725-127930113 bp, - strand
From Ensembl annotation of GRCm38

  4389 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20613  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

HCOP human homology predictions: PRSS8
Protein SuperFamily: trypsin
Gene Tree: Prss8

Human
homologs
PRSS8, protease, serine, 8
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5652
neXtProt AC: NX_Q16651

Human Synonyms: CAP1, PROSTASIN

Human Chr (Location): 16p11.2; chr16:31131433-31135830 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(4) Spontaneous(1) Targeted(8)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mutations in this gene result in abnormal vibrissae and coat growth.
 
Human Diseases Modeled in Mice Using Prss8 (1)    Mutations Annotated to Human Diseases (2)    Phenotype Images(2)
Interactions
Prss8 interacts with 81 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (8 records)
Data Summary: Results (227)    Tissues (112)    Images (27)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 181
RT-PCR 46
cDNA source data(9)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase prss8    NEW 
Molecular
reagents
All nucleic(11) cDNA(9) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000030800 (Evidence)
Entrez Gene 76560 (Evidence)
EC 3.4.21.-
Consensus CDS Project CCDS40147.1
International Mouse Phenotyping Consortium Status Prss8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030800 Ensembl Gene Model | MGI Sequence Detail 4389 C57BL/6J ±  kb
transcript ENSMUST00000032988 Ensembl | MGI Sequence Detail 1852 Not Applicable 
polypeptide ENSMUSP00000032988 Ensembl | MGI Sequence Detail 339 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(4) UniProt(4)
Polymorphisms
SNPs within 2kb(115 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000013330 prostasin
References
(Earliest) J:64269 Snell GD, fr - frizzy. Mouse News Lett. 1951;5:36
(Latest) J:221394 Szabo R, et al., Regulation of feto-maternal barrier by matriptase- and PAR-2-mediated signaling is required for placental morphogenesis and mouse embryonic survival. PLoS Genet. 2014 Jul;10(7):e1004470
All references(63)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-9870, MGI:2141897, MGI:2142334, MGI:95577

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory