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Prss8
Gene Detail
Symbol

Name
ID
Prss8
protease, serine 8 (prostasin)
MGI:1923810
Synonyms
2410039E18Rik, CAP1, fr, mCAP1
Feature Type
protein coding gene
Genetic Map
Chromosome 7
69.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(17)
Sequence Map
Chr7:127925725-127930113 bp, - strand
From Ensembl annotation of GRCm38

  4389 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20613  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

HCOP human homology predictions: PRSS8
Protein SuperFamily: trypsin
Gene Tree: Prss8

Human
homologs
PRSS8, protease, serine, 8
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5652
neXtProt AC: NX_Q16651

Human Synonyms: CAP1, PROSTASIN

Human Chr (Location): 16p11.2; chr16:31131433-31135830 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(4) Spontaneous(1) Targeted(9)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Human Diseases Modeled in Mice Using Prss8 (1)    Mutations Annotated to Human Diseases (2)    Phenotype Images(2)
Interactions
Prss8 interacts with 81 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (9 records)
Data Summary: Results (227)    Tissues (112)    Images (27)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 181
RT-PCR 46
cDNA source data(9)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase prss8    NEW 
Molecular
reagents
All nucleic(11) cDNA(9) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000030800 (Evidence)
Entrez Gene 76560 (Evidence)
EC 3.4.21.-
Consensus CDS Project CCDS40147.1
International Mouse Phenotyping Consortium Status Prss8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030800 Ensembl Gene Model | MGI Sequence Detail 4389 C57BL/6J ±  kb
transcript ENSMUST00000032988 Ensembl | MGI Sequence Detail 1852 Not Applicable 
polypeptide ENSMUSP00000032988 Ensembl | MGI Sequence Detail 339 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(4) UniProt(4)
Polymorphisms
SNPs within 2kb(115 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000013330 prostasin
References
(Earliest) J:64269 Snell GD, fr - frizzy. Mouse News Lett. 1951;5:36
(Latest) J:221394 Szabo R, et al., Regulation of feto-maternal barrier by matriptase- and PAR-2-mediated signaling is required for placental morphogenesis and mouse embryonic survival. PLoS Genet. 2014 Jul;10(7):e1004470
All references(64)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-9870, MGI:2141897, MGI:2142334, MGI:95577

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory