About   Help   FAQ
Prss8
Gene Detail
 Symbol
Name
ID
Prss8
protease, serine 8 (prostasin)
MGI:1923810
Synonyms 2410039E18Rik, CAP1, fr, mCAP1
Feature Type protein coding gene
Genetic Map
Chromosome 7
69.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(17)
Sequence Map
Chr7:127925725-127930113 bp, - strand
From Ensembl annotation of GRCm38

  4389 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20613  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

Protein SuperFamily: trypsin
Gene Tree: Prss8

Human
homologs
Human Homolog PRSS8, protease, serine, 8
NCBI Gene ID 5652
neXtProt AC  NX_Q16651
Human Synonyms  CAP1, PROSTASIN
Human Chr (Location)  16p11.2; chr16:31131433-31135830 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(4) Spontaneous(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mutations in this gene result in abnormal vibrissae and coat growth.
 
Human Diseases Modeled Using Mouse Prss8 (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(2)
Interactions
Prss8 interacts with 81 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process hair follicle development, positive regulation of sodium ion transport, ...
Component anchored component of plasma membrane, extracellular region, ...
Function catalytic activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (227)    Tissues (112)    Images (27)
Theiler Stages: 14, 23, 26, 28
Assay TypeResults
RNA in situ 181
RT-PCR 46
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) cDNA(9) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000030800 (Evidence)
Entrez Gene76560 (Evidence)
EC3.4.21.-
Consensus CDS ProjectCCDS40147.1
International Mouse Knockout Project StatusPrss8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030800 Ensembl Gene Model | MGI Sequence Detail 4389 C57BL/6J ±  kb
transcript ENSMUST00000032988 Ensembl | MGI Sequence Detail 1852 Not Applicable 
polypeptide ENSMUSP00000032988 Ensembl | MGI Sequence Detail 339 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(4) UniProt(4)
Polymorphisms SNPs within 2kb(115 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000013330 prostasin
References (Earliest) J:64269 Snell GD, fr - frizzy. Mouse News Lett. 1951;5:36
(Latest) J:197433 Metcalf D, et al., Concordant mast cell and basophil production by individual hematopoietic blast colony-forming cells. Proc Natl Acad Sci U S A. 2013 May 28;110(22):9031-5
All references(60)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-9870, MGI:2141897, MGI:2142334, MGI:95577

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/02/2014
MGI 5.19
The Jackson Laboratory