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Ip6k2
Gene Detail
Symbol

Name
ID
Ip6k2
inositol hexaphosphate kinase 2
MGI:1923750
Synonyms
1500005N04Rik, Ihpk2
Feature Type
protein coding gene
Genetic Map
Chromosome 9
59.63 cM, cytoband F2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr9:108783796-108806337 bp, + strand
From VEGA annotation of GRCm38

  22542 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56929  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: IP6K2
Gene Tree: Ip6k2

Human
homologs
IP6K2, inositol hexakisphosphate kinase 2
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 51447
neXtProt AC: NX_Q9UHH9

Human Synonyms: IHPK2, PIUS

Human Chr (Location): 3p21.31; chr3:48688003-48717278 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(41) : Gene trapped(39) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit resistance to radiation induced lethality, increased double-strand break repair, and increased incidence of chemically-induced aerodigestive tract carcinoma.
 
Interactions
Ip6k2 interacts with 87 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (3 records)
Data Summary: Results (113)    Tissues (105)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 113
cDNA source data(9)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ip6k2 ; ZFIN ip6k2b    NEW 
Molecular
reagents
All nucleic(11) cDNA(10) Primer pair(1)
Microarray probesets(10)
Other database
links
VEGA Gene Model OTTMUSG00000050674 (Evidence)
Ensembl Gene Model ENSMUSG00000032599 (Evidence)
Entrez Gene 76500 (Evidence)
DFCI TC1579399, TC1583056, TC1602577, TC1594145, TC1595528, TC1627058, TC1736454, TC1745681
DoTS DT.40138539, DT.110632373, DT.101722724, DT.101377947, DT.50316030, DT.94217219, DT.87035329, DT.94217224, DT.94217235
NIA Mouse Gene Index U011038
EC 2.7.4.21
Consensus CDS Project CCDS23537.1
International Mouse Phenotyping Consortium Status Ip6k2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050674 VEGA Gene Model | MGI Sequence Detail 22542 C57BL/6J ±  kb
transcript OTTMUST00000128463 VEGA | MGI Sequence Detail 1846 Not Applicable 
polypeptide OTTMUSP00000069107 VEGA | MGI Sequence Detail 448 Not Applicable 

For the selected sequences
All sequences(108) RefSeq(16) UniProt(10)
Polymorphisms
SNPs within 2kb(72 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005522 Inositol polyphosphate kinase
Protein Ontology PR:000009081 inositol hexakisphosphate kinase 2
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:212482 Rao F, et al., Inositol pyrophosphates mediate the DNA-PK/ATM-p53 cell death pathway by regulating CK2 phosphorylation of Tti1/Tel2. Mol Cell. 2014 Apr 10;54(1):119-32
All references(36)
Other
accession IDs
MGI:2143285

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory