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Clasp2 Gene Detail
Summary
  • Symbol
    Clasp2
  • Name
    CLIP associating protein 2
  • Synonyms
    1500004F14Rik, 8030404L10Rik, CLASP2, CLASP2alpha, CLASP2beta, CLASP2gamma, mKIAA0627
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923749
    NCBI Gene: 76499
  • Gene Overview
    MyGene.info: CLASP2
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:113741473-113919682 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 64.06 cM, cytoband F2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    677 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923749
protein coding gene Chr9:113741059-113919697 (.)
129S1/SvImJ MGP_129S1SvImJ_G0035380
protein coding gene Chr9:116185113-116297547 (+)
A/J MGP_AJ_G0035361
protein coding gene Chr9:111868949-111976450 (+)
AKR/J MGP_AKRJ_G0035292
protein coding gene Chr9:114720348-114830085 (+)
BALB/cJ MGP_BALBcJ_G0035356
protein coding gene Chr9:111690405-111801549 (+)
C3H/HeJ MGP_C3HHeJ_G0035064
protein coding gene Chr9:115242663-115349489 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035877
protein coding gene Chr9:119344714-119462348 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032764
protein coding gene Chr9:109009211-109129239 (+)
CAST/EiJ MGP_CASTEiJ_G0034370
protein coding gene Chr9:115003602-115202828 (+)
CBA/J MGP_CBAJ_G0035031
protein coding gene Chr9:123748713-123861427 (+)
DBA/2J MGP_DBA2J_G0035189
protein coding gene Chr9:111337801-111446209 (+)
FVB/NJ MGP_FVBNJ_G0035136
protein coding gene Chr9:110158657-110266337 (+)
LP/J MGP_LPJ_G0035269
protein coding gene Chr9:116488683-116599893 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035177
protein coding gene Chr9:124996303-125110469 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035898
protein coding gene Chr9:115112581-115233911 (+)
PWK/PhJ MGP_PWKPhJ_G0034075
protein coding gene Chr9:111555901-111739194 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033910
protein coding gene Chr9:115102524-115288540 (+)
WSB/EiJ MGP_WSBEiJ_G0034490
protein coding gene Chr9:114961818-115072974 (+)



Homology
more
  • Human Ortholog
    CLASP2, cytoplasmic linker associated protein 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CLASP2, cytoplasmic linker associated protein 2
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 23122
    neXtProt AC: NX_O75122
    UniProt: O75122

  • Chr Location
    3p22.3; chr3:33496245-33718356 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Targeted deletion of this gene leads to impaired formation of stable microtubules in a wound healing assay, and results in a 2-fold reduction of directionally persistent migration in mutant embryonic fibroblasts.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000033392 Ensembl Gene Model | MGI Sequence Detail 178210 C57BL/6J ±  kb
transcript ENSMUST00000163895 Ensembl | MGI Sequence Detail 4112 Not Applicable  
polypeptide ENSMUSP00000128460 Ensembl | MGI Sequence Detail 1307 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 99
    cDNA 96
    Primer pair 3

    Microarray probesets 6
Other
Accession IDs
less
MGI:2143386
References
more
  • Summaries
    All 44
    Developmental Gene Expression 6
    Gene Ontology 8
    Phenotypes 6
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:246269 Shahbazi MN, et al., Clasp2 ensures mitotic fidelity and prevents differentiation of epidermal keratinocytes. J Cell Sci. 2017 Feb 15;130(4):683-688

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory