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Kctd13 Gene Detail
Summary
  • Symbol
    Kctd13
  • Name
    potassium channel tetramerisation domain containing 13
  • Synonyms
    1500003N18Rik, Pdip1, Poldip1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923739
    NCBI Gene: 233877
  • Gene Overview
    MyGene.info: KCTD13
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:126928879-126945631 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 69.25 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    74 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923739
protein coding gene Chr7:126928844-126947897 (.)
129S1/SvImJ MGP_129S1SvImJ_G0033008
protein coding gene Chr7:131236251-131255963 (+)
A/J MGP_AJ_G0032991
protein coding gene Chr7:127755756-127773308 (+)
AKR/J MGP_AKRJ_G0032923
protein coding gene Chr7:130990693-131007402 (+)
BALB/cJ MGP_BALBcJ_G0032996
protein coding gene Chr7:127418814-127436386 (+)
C3H/HeJ MGP_C3HHeJ_G0032706
protein coding gene Chr7:130930174-130946874 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033502
protein coding gene Chr7:136344548-136360999 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030474
protein coding gene Chr7:128964702-128982536 (+)
CAST/EiJ MGP_CASTEiJ_G0032035
protein coding gene Chr7:122717204-122735118 (+)
CBA/J MGP_CBAJ_G0032679
protein coding gene Chr7:140929006-140947231 (+)
DBA/2J MGP_DBA2J_G0032831
protein coding gene Chr7:125730817-125747527 (+)
FVB/NJ MGP_FVBNJ_G0032784
protein coding gene Chr7:125580850-125597573 (+)
LP/J MGP_LPJ_G0032925
protein coding gene Chr7:132702801-132720409 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032816
protein coding gene Chr7:142098226-142115040 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033521
protein coding gene Chr7:130003928-130023046 (+)
PWK/PhJ MGP_PWKPhJ_G0031742
protein coding gene Chr7:118725613-118742810 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031588
protein coding gene Chr7:116845806-116862698 (+)
WSB/EiJ MGP_WSBEiJ_G0032147
protein coding gene Chr7:130982026-130999611 (+)



Homology
more
  • Human Ortholog
    KCTD13, potassium channel tetramerization domain containing 13
  • Vertebrate Orthologs
    7
  • Human Ortholog
    KCTD13, potassium channel tetramerization domain containing 13
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BACURD1, FKSG86, hBACURD1, PDIP1, POLDIP1
  • Links
    NCBI Gene ID: 253980
    neXtProt AC: NX_Q8WZ19
    UniProt: Q8WZ19

  • Chr Location
    16p11.2; chr16:29906335-29926247 (-)  GRCh38.p7

Human Diseases
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  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced synaptic transmission, abnormal hippocampal pyramidal neuron dendrite morphology, and hyperactivity with no detectable changes in body weight, brain size or neurogenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030685 Ensembl Gene Model | MGI Sequence Detail 16753 C57BL/6J ±  kb
    transcript ENSMUST00000032924 Ensembl | MGI Sequence Detail 1676 Not Applicable  
    polypeptide ENSMUSP00000032924 Ensembl | MGI Sequence Detail 329 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000031144 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1
    • InterPro Domains
      IPR000210 BTB/POZ domain
      IPR003131 Potassium channel tetramerisation-type BTB domain
      IPR011333 SKP1/BTB/POZ domain superfamily
    Molecular
    Reagents
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    • All nucleic 38
      Genomic 2
      cDNA 35
      Primer pair 1

      Microarray probesets 6
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 2
      Diseases 3
      Gene Ontology 5
      Phenotypes 19
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:263550 Wang W, et al., Chemogenetic Activation of Prefrontal Cortex Rescues Synaptic and Behavioral Deficits in a Mouse Model of 16p11.2 Deletion Syndrome. J Neurosci. 2018 Jun 27;38(26):5939-5948

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory