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Kctd13 Gene Detail
Summary
  • Symbol
    Kctd13
  • Name
    potassium channel tetramerisation domain containing 13
  • Synonyms
    1500003N18Rik, Pdip1, Poldip1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923739
    NCBI Gene: 233877
  • Gene Overview
    MyGene.info: KCTD13
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr7:126928879-126945631 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      16753 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 69.25 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    KCTD13, potassium channel tetramerization domain containing 13
  • Vertebrate Orthologs
    7
  • Human Ortholog
    KCTD13, potassium channel tetramerization domain containing 13
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BACURD1, FKSG86, hBACURD1, PDIP1, POLDIP1
  • Links
    NCBI Gene ID: 253980
    neXtProt AC: NX_Q8WZ19
    UniProt: Q8WZ19

  • Chr Location
    16p11.2; chr16:29906335-29926247 (-)  GRCh38.p7

Human Diseases
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  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced synaptic transmission, abnormal hippocampal pyramidal neuron dendrite morphology, and hyperactivity with no detectable changes in body weight, brain size or neurogenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000023162 VEGA Gene Model | MGI Sequence Detail 16753 C57BL/6J ±  kb
    transcript OTTMUST00000056002 VEGA | MGI Sequence Detail 1676 Not Applicable  
    polypeptide OTTMUSP00000026872 VEGA | MGI Sequence Detail 329 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      74 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000031144 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1
    • InterPro Domains
      IPR000210 BTB/POZ domain
      IPR003131 Potassium channel tetramerisation-type BTB domain
      IPR011333 SKP1/BTB/POZ domain superfamily
    Molecular
    Reagents
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    • All nucleic 37
      Genomic 1
      cDNA 35
      Primer pair 1

      Microarray probesets 6
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 2
      Diseases 3
      Gene Ontology 5
      Phenotypes 18
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:257347 Panzini CM, et al., 16p11.2 deletion syndrome mice perseverate with active coping response to acute stress - rescue by blocking 5-HT2A receptors. J Neurochem. 2017 Dec;143(6):708-721

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory