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Kndc1 Gene Detail
Summary
  • Symbol
    Kndc1
  • Name
    kinase non-catalytic C-lobe domain (KIND) containing 1
  • Synonyms
    2410012C07Rik, B830014K08Rik, very-kind, VKIND
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923734
    NCBI Gene: 76484
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:139894696-139941537 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 84.89 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    348 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923734
protein coding gene Chr7:139894696-139941540 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033154
protein coding gene Chr7:144969377-145017027 (+)
A/J MGP_AJ_G0033136
protein coding gene Chr7:140850991-140897525 (+)
AKR/J MGP_AKRJ_G0033068
protein coding gene Chr7:144677578-144730545 (+)
BALB/cJ MGP_BALBcJ_G0033137
protein coding gene Chr7:140589787-140636966 (+)
C3H/HeJ MGP_C3HHeJ_G0032851
protein coding gene Chr7:144484077-144530761 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033648
protein coding gene Chr7:150312383-150358792 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030621
protein coding gene Chr7:141974813-142022028 (+)
CAST/EiJ MGP_CASTEiJ_G0032181
protein coding gene Chr7:136784130-136832158 (+)
CBA/J MGP_CBAJ_G0032824
protein coding gene Chr7:155381162-155427841 (+)
DBA/2J MGP_DBA2J_G0032976
protein coding gene Chr7:138804830-138851771 (+)
FVB/NJ MGP_FVBNJ_G0032929
protein coding gene Chr7:138689799-138737963 (+)
LP/J MGP_LPJ_G0033070
protein coding gene Chr7:146509614-146561442 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032961
protein coding gene Chr7:156044798-156092710 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033668
protein coding gene Chr7:143684727-143732490 (+)
PWK/PhJ MGP_PWKPhJ_G0031887
protein coding gene Chr7:131998824-132046255 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031732
protein coding gene Chr7:130511594-130568619 (+)
WSB/EiJ MGP_WSBEiJ_G0032292
protein coding gene Chr7:144580670-144629083 (+)



Homology
more
  • Human Ortholog
    KNDC1, kinase non-catalytic C-lobe domain containing 1
  • Vertebrate Orthologs
    6
  • Human Ortholog
    KNDC1, kinase non-catalytic C-lobe domain containing 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    bB439H18.3, C10orf23, RASGEF2, Very-KIND, v-KIND
  • Links
    NCBI Gene ID: 85442
    neXtProt AC: NX_Q76NI1
    UniProt: Q76NI1

  • Chr Location
    10q26.3; chr10:133160096-133226412 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    2 images
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable and overtly normal but exhibit altered dendritic growth and excitatory synaptic connections in cerebellar granule cells, increased grip strength, and enhanced motor coordination in balance-related tests.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    • All Sequences
    • RefSeq
    • UniProt
    • UniGene
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000066129 Ensembl Gene Model | MGI Sequence Detail 46842 C57BL/6J ±  kb
    transcript ENSMUST00000053445 Ensembl | MGI Sequence Detail 7299 Not Applicable  
    polypeptide ENSMUSP00000050586 Ensembl | MGI Sequence Detail 1742 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000009429 kinase non-catalytic C-lobe domain-containing protein 1
    • InterPro Domains
      IPR029899 Kinase non-catalytic C-lobe domain-containing protein 1
      IPR011019 KIND domain
      IPR011009 Protein kinase-like domain superfamily
      IPR036964 Ras guanine-nucleotide exchange factor catalytic domain superfamily
      IPR023578 Ras guanine nucleotide exchange factor domain superfamily
      IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
      IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
    Molecular
    Reagents
    less
    • All nucleic 37
      cDNA 34
      Primer pair 2
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2444744
    References
    more
    • Summaries
      All 33
      Developmental Gene Expression 4
      Gene Ontology 5
      Phenotypes 9
    • Earliest
      J:65007 Cattanach BM, et al., Two imprinted gene mutations: three phenotypes. Hum Mol Genet. 2000 Sep 22;9(15):2263-73
    • Latest
      J:246827 Hayashi K, et al., The brain-specific RasGEF very-KIND is required for normal dendritic growth in cerebellar granule cells and proper motor coordination. PLoS One. 2017;12(3):e0173175

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    09/05/2019
    MGI 6.14
    The Jackson Laboratory