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Kndc1 Gene Detail
Summary
  • Symbol
    Kndc1
  • Name
    kinase non-catalytic C-lobe domain (KIND) containing 1
  • Synonyms
    2410012C07Rik, B830014K08Rik, very-kind, VKIND
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923734
    NCBI Gene: 76484
Location & Maps
more
  • Sequence Map
    Chr7:139894696-139941537 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      46842 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 84.89 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    KNDC1, kinase non-catalytic C-lobe domain containing 1
  • Vertebrate Orthologs
    6
  • Human Ortholog
    KNDC1, kinase non-catalytic C-lobe domain containing 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    bB439H18.3, C10orf23, RASGEF2
  • Links
    NCBI Gene ID: 85442
    neXtProt AC: NX_Q76NI1

  • Chr Location
    10q26.3; chr10:133160467-133226412 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    8 phenotype references
  • All Mutations and Alleles
    6
  • Gene trapped
    2
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    1 involving Kndc1
  • Incidental Mutations
Mice homozygous for a knock-out allele are viable and overtly normal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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  • All Sequences
  • RefSeq
  • UniProt
  • UniGene
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029674 VEGA Gene Model | MGI Sequence Detail 46842 C57BL/6J ±  kb
transcript OTTMUST00000073619 VEGA | MGI Sequence Detail 3486 Not Applicable  
polypeptide OTTMUSP00000038137 VEGA | MGI Sequence Detail 998 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    348 from dbSNP Build 142
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000009429 protein very KIND
  • InterPro Domains
    IPR011019 KIND domain
    IPR011009 Protein kinase-like domain
    IPR029899 Protein very KIND
    IPR023578 Ras guanine nucleotide exchange factor domain
    IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
    IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
Molecular
Reagents
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  • All nucleic 33
    cDNA 32
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
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MGI:2444744
References
more
  • Summaries
    All 28
    Developmental Gene Expression 4
    Gene Ontology 4
    Phenotypes 8
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:187556 Huang J, et al., Interaction between very-KIND Ras guanine exchange factor and microtubule-associated protein 2, and its role in dendrite growth--structure and function of the second kinase noncatalytic C-lobe domain. FEBS J. 2011 May;278(10):1651-61

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory