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Eif4a3 Gene Detail
Summary
  • Symbol
    Eif4a3
  • Name
    eukaryotic translation initiation factor 4A3
  • Synonyms
    2400003O03Rik, Ddx48, mKIAA0111
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923731
    NCBI Gene: 192170
  • Gene Overview
    MyGene.info: EIF4A3
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:119288363-119300043 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 83.35 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    98 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923731
protein coding gene Chr11:119288363-119300089 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019478
protein coding gene Chr11:123660966-123679822 (-)
A/J MGP_AJ_G0019446
protein coding gene Chr11:118190242-118202411 (-)
AKR/J MGP_AKRJ_G0019416
protein coding gene Chr11:121748615-121760653 (-)
BALB/cJ MGP_BALBcJ_G0019421
protein coding gene Chr11:118548413-118560324 (-)
C3H/HeJ MGP_C3HHeJ_G0019227
protein coding gene Chr11:122064776-122076418 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019870
protein coding gene Chr11:127435658-127452279 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017495
protein coding gene Chr11:115184330-115195408 (-)
CAST/EiJ MGP_CASTEiJ_G0018781
protein coding gene Chr11:123519713-123534745 (-)
CBA/J MGP_CBAJ_G0019198
protein coding gene Chr11:132387788-132407440 (-)
DBA/2J MGP_DBA2J_G0019310
protein coding gene Chr11:117562413-117574783 (-)
FVB/NJ MGP_FVBNJ_G0019302
protein coding gene Chr11:117229446-117241472 (-)
LP/J MGP_LPJ_G0019380
protein coding gene Chr11:123975295-123990335 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019335
protein coding gene Chr11:131322981-131337806 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019909
protein coding gene Chr11:122420817-122434436 (-)
PWK/PhJ MGP_PWKPhJ_G0018547
protein coding gene Chr11:118968566-118980471 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018339
protein coding gene Chr11:122176476-122189877 (-)
WSB/EiJ MGP_WSBEiJ_G0018833
protein coding gene Chr11:122391058-122408790 (-)



Homology
more
  • Human Ortholog
    EIF4A3, eukaryotic translation initiation factor 4A3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    EIF4A3, eukaryotic translation initiation factor 4A3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    DDX48, eIF4AIII, eIF-4A-III, eIF4A-III, Fal1, MUK34, NMP265, NUK34, RCPS
  • Links
    NCBI Gene ID: 9775
    neXtProt AC: NX_P38919
    UniProt: P38919

  • Chr Location
    17q25.3; chr17:80135214-80147183 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 5602
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: EIF4A3
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 192170 NCBI Gene Model | MGI Sequence Detail 11681 C57BL/6J ±  kb
transcript NM_138669 RefSeq | MGI Sequence Detail 1489 FVB/N  
polypeptide NP_619610 RefSeq | MGI Sequence Detail 411 FVB/N  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    cDNA 14

    Microarray probesets 8
References
more
  • Summaries
    All 29
    Developmental Gene Expression 3
    Gene Ontology 3
    Phenotypes 4
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:242590 Miller EE, et al., EIF4A3 deficient human iPSCs and mouse models demonstrate neural crest defects that underlie Richieri-Costa-Pereira syndrome. Hum Mol Genet. 2017 Jun 15;26(12):2177-2191

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory