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Supt3 Gene Detail
Summary
  • Symbol
    Supt3
  • Name
    SPT3, SAGA and STAGA complex component
  • Synonyms
    2310066G22Rik, SPT3, SPT3L, Supt3h
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923723
    NCBI Gene: 109115
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:45088039-45430177 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 21.56 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1620 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923723
 protein coding gene Chr17:45088005-45430181 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023785
 protein coding gene Chr17:45754666-46101541 (+)
A/J MGP_AJ_G0023743
 protein coding gene Chr17:44685840-45014842 (+)
AKR/J MGP_AKRJ_G0023714
 protein coding gene Chr17:44968381-45310070 (+)
BALB/cJ MGP_BALBcJ_G0023747
 protein coding gene Chr17:44562897-44906903 (+)
C3H/HeJ MGP_C3HHeJ_G0023511
 protein coding gene Chr17:45679497-46029828 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024190
 protein coding gene Chr17:47755818-48107324 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021640
 protein coding gene Chr17:41488930-41822148 (+)
CAST/EiJ MGP_CASTEiJ_G0022992
 protein coding gene Chr17:45756979-46113800 (+)
CBA/J MGP_CBAJ_G0023487
 protein coding gene Chr17:49445294-49807907 (+)
DBA/2J MGP_DBA2J_G0023613
 protein coding gene Chr17:43481033-43811046 (+)
FVB/NJ MGP_FVBNJ_G0023580
 protein coding gene Chr17:43050043-43385244 (+)
LP/J MGP_LPJ_G0023694
 protein coding gene Chr17:46420853-46765509 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023609
 protein coding gene Chr17:49034767-49396706 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024235
 protein coding gene Chr17:45331619-45667575 (+)
PWK/PhJ MGP_PWKPhJ_G0022737
 protein coding gene Chr17:42764086-43102339 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022552
 protein coding gene Chr17:42189507-42538837 (+)
WSB/EiJ MGP_WSBEiJ_G0023057
 protein coding gene Chr17:45851133-46198622 (+)



Homology
more
  • Human Ortholog
    SUPT3H, SPT3 homolog, SAGA and STAGA complex component
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SUPT3H, SPT3 homolog, SAGA and STAGA complex component
  • Synonyms
    SPT3, SPT3L
  • Links
    NCBI Gene ID: 8464
    neXtProt AC: NX_O75486
    UniProt: O75486

  • Chr Location
    6p21.1; chr6:44809057-45377953 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit defects in chorion formation and placentation, abnormal trophoblast layer morphology, and complete lethality throughout fetal growth and development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    730
  • Tissues
    15
  • cDNA Data
    31
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038954 Ensembl Gene Model | MGI Sequence Detail 342139 C57BL/6J ±  kb
    transcript ENSMUST00000129416 Ensembl | MGI Sequence Detail 1218 Not Applicable  
    polypeptide ENSMUSP00000120197 Ensembl | MGI Sequence Detail 406 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • InterPro Domains
      IPR009072 Histone-fold
      IPR003195 Transcription initiation factor IID, subunit 13
    Molecular
    Reagents
    less
    • All nucleic 31
      cDNA 31

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2146819
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 1
      Gene Ontology 3
      Phenotypes 7
    • Earliest
      J:320277 Ogryzko VV, et al., Histone-like TAFs within the PCAF histone acetylase complex. Cell. 1998 Jul 10;94(1):35-44
    • Latest
      J:274872 Ingham NJ, et al., Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS Biol. 2019 Apr;17(4):e3000194
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory