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Car12
Gene Detail
Symbol

Name
ID
Car12
carbonic anyhydrase 12
MGI:1923709
Synonyms
2310047E01Rik, CA XII
Feature Type
protein coding gene
Genetic Map
Chromosome 9
36.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:66713686-66766845 bp, + strand
From VEGA annotation of GRCm38

  53160 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20327  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CA12
Protein SuperFamily: carbonate dehydratase
Gene Tree: Car12

Human
homologs
CA12, carbonic anhydrase XII
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 771
neXtProt AC: NX_O43570

Human Synonyms: CAXII, HsT18816

Human Chr (Location): 15q22; chr15:63323531-63382110 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CA12

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(3) Transposon induced(1)
Incidental mutations (data from CvDC )
 
Mice homozygous for a transposon-induced mutation that inactivates this gene display reduced fitness.
 
Interactions
Car12 interacts with 316 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process carbon dioxide transport, chloride ion homeostasis, ...
Component integral component of membrane, membrane
Function carbonate dehydratase activity, lyase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (268)    Tissues (155)    Images (70)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 39
RNA in situ 229
cDNA source data(69)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(70) cDNA(69) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000025353 (Evidence)
Ensembl Gene Model ENSMUSG00000032373 (Evidence)
Entrez Gene 76459 (Evidence)
UniGene 277921
DFCI TC1577682, TC1757019, TC1717725, TC1685879
DoTS DT.40151649, DT.101409780, DT.485323, DT.94194994, DT.91379116
NIA Mouse Gene Index U010658
EC 4.2.1.1
Consensus CDS Project CCDS23306.1
International Mouse Phenotyping Consortium Status Car12
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025353 VEGA Gene Model | MGI Sequence Detail 53160 C57BL/6J ±  kb
transcript OTTMUST00000062411 VEGA | MGI Sequence Detail 3716 Not Applicable 
polypeptide OTTMUSP00000030757 VEGA | MGI Sequence Detail 354 Not Applicable 

For the selected sequences
All sequences(57) RefSeq(6) UniProt(5)
Polymorphisms
SNPs within 2kb(467 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001148 Alpha carbonic anhydrase
InterPro IPR023561 Carbonic anhydrase, alpha-class
InterPro IPR018338 Carbonic anhydrase, alpha-class, conserved site
InterPro IPR018430 Carbonic anhydrase, CA-XII
Protein Ontology PR:000004915 carbonic anhydrase 12
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:193048 Wu L, et al., A systematic survey of carbonic anhydrase mRNA expression during Mammalian inner ear development. Dev Dyn. 2013 Mar;242(3):269-80
All references(39)
Other
accession IDs
MGI:2143012

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory