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Car12 Gene Detail
Summary
  • Symbol
    Car12
  • Name
    carbonic anhydrase 12
  • Synonyms
    2310047E01Rik, CA XII
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923709
    NCBI Gene: 76459
Location & Maps
more
  • Sequence Map
    Chr9:66713686-66766845 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      53160 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    CA12, carbonic anhydrase XII
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CA12, carbonic anhydrase XII
    Orthology source: HomoloGene
  • Synonyms
    CAXII, HsT18816
  • Links
    NCBI Gene ID: 771
    neXtProt AC: NX_O43570

  • Chr Location
    15q22; chr15:63323531-63382110 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human CA12 associations

Human Disease Mouse Models
       Hyperchlorhidrosis, Isolated   OMIM: 143860
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Targeted
    3
  • Transposon induced
    1
  • Genomic Mutations
    1 involving Car12
  • Incidental Mutations
Mice homozygous for a transposon-induced mutation that inactivates this gene display reduced fitness.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025353 VEGA Gene Model | MGI Sequence Detail 53160 C57BL/6J ±  kb
transcript OTTMUST00000062411 VEGA | MGI Sequence Detail 3716 Not Applicable  
polypeptide OTTMUSP00000030757 VEGA | MGI Sequence Detail 354 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    467 from dbSNP Build 137
Protein
Information
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  • UniProt
    6 Sequences
  • EC
  • InterPro Domains
    IPR001148 Alpha carbonic anhydrase
    IPR023561 Carbonic anhydrase, alpha-class
    IPR018338 Carbonic anhydrase, alpha-class, conserved site
    IPR018430 Carbonic anhydrase, CA-XII
Molecular
Reagents
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  • All nucleic 70
    cDNA 69
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:2143012
References
more
  • Summaries
    All 35
    Developmental Gene Expression 7
    Gene Ontology 4
    Phenotypes 7
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:193048 Wu L, et al., A systematic survey of carbonic anhydrase mRNA expression during Mammalian inner ear development. Dev Dyn. 2013 Mar;242(3):269-80

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory