About   Help   FAQ
Car12
Gene Detail
 Symbol
Name
ID
Car12
carbonic anyhydrase 12
MGI:1923709
Synonyms 2310047E01Rik, CA XII
Feature Type protein coding gene
Genetic Map
Chromosome 9
36.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:66713686-66766845 bp, + strand
From VEGA annotation of GRCm38

  53160 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20327  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: carbonate dehydratase
Gene Tree: Car12

Human
homologs
Human Homolog CA12, carbonic anhydrase XII
NCBI Gene ID 771
neXtProt AC  NX_O43570
Human Synonyms  CAXII, HsT18816
Human Chr (Location)  15q22; chr15:63323531-63381876 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human CA12
Alleles
and
phenotypes
All alleles(3) : Targeted(2) Transposon induced(1)
 
Mice homozygous for a transposon-induced mutation that inactivates this gene display reduced fitness.
 
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process one-carbon metabolic process
Component integral component of membrane, membrane
Function carbonate dehydratase activity, lyase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (268)    Tissues (155)    Images (70)
Theiler Stages: 11, 19, 20, 21, 22, 23, 28
Assay TypeResults
Immunohistochemistry 39
RNA in situ 229
cDNA source data(69)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(70) cDNA(69) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000025353 (Evidence)
Ensembl Gene ModelENSMUSG00000032373 (Evidence)
Entrez Gene76459 (Evidence)
UniGene277921
DFCITC1577682, TC1685879, TC1717725, TC1757019
DoTSDT.101409780, DT.40151649, DT.485323, DT.91379116, DT.94194994
NIA Mouse Gene IndexU010658
EC4.2.1.1
Consensus CDS ProjectCCDS23306.1
International Mouse Knockout Project StatusCar12
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025353 VEGA Gene Model | MGI Sequence Detail 53160 C57BL/6J ±  kb
transcript OTTMUST00000062411 VEGA | MGI Sequence Detail 3716 Not Applicable 
polypeptide OTTMUSP00000030757 VEGA | MGI Sequence Detail 354 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(6) UniProt(5)
Polymorphisms SNPs within 2kb(467 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001148 Alpha carbonic anhydrase
InterPro IPR023561 Carbonic anhydrase, alpha-class
InterPro IPR018338 Carbonic anhydrase, alpha-class, conserved site
InterPro IPR018430 Carbonic anhydrase, CA-XII
Protein Ontology PR:000004915 carbonic anhydrase 12
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:193048 Wu L, et al., A systematic survey of carbonic anhydrase mRNA expression during Mammalian inner ear development. Dev Dyn. 2013 Mar;242(3):269-80
All references(39)
Other
accession IDs
MGI:2143012

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/15/2014
MGI 5.17
The Jackson Laboratory