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Wdr62 Gene Detail
Summary
  • Symbol
    Wdr62
  • Name
    WD repeat domain 62
  • Synonyms
    2310038K02Rik, b2b1508Clo, MGC:31423
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923696
    NCBI Gene: 233064
  • Gene Overview
    MyGene.info: WDR62
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:30240138-30280419 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 17.34 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    579 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923696
protein coding gene Chr7:30240138-30280421 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032009
protein coding gene Chr7:29221106-29265648 (-)
A/J MGP_AJ_G0031986
protein coding gene Chr7:28451547-28490917 (-)
AKR/J MGP_AKRJ_G0031919
protein coding gene Chr7:29179231-29222598 (-)
BALB/cJ MGP_BALBcJ_G0031993
protein coding gene Chr7:28626914-28666303 (-)
C3H/HeJ MGP_C3HHeJ_G0031712
protein coding gene Chr7:29620537-29664183 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032458
protein coding gene Chr7:30167424-30209478 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029509
protein coding gene Chr7:29486592-29527087 (-)
CAST/EiJ MGP_CASTEiJ_G0031046
protein coding gene Chr7:22873824-22916041 (-)
CBA/J MGP_CBAJ_G0031678
protein coding gene Chr7:31620584-31672540 (-)
DBA/2J MGP_DBA2J_G0031830
protein coding gene Chr7:28180283-28219975 (-)
FVB/NJ MGP_FVBNJ_G0031787
protein coding gene Chr7:28293741-28337859 (-)
LP/J MGP_LPJ_G0031911
protein coding gene Chr7:29544951-29585104 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031823
protein coding gene Chr7:30879659-30921209 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032487
protein coding gene Chr7:28676702-28718122 (-)
PWK/PhJ MGP_PWKPhJ_G0030772
protein coding gene Chr7:23212283-23254368 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030605
protein coding gene Chr7:19676421-19722243 (-)
WSB/EiJ MGP_WSBEiJ_G0031156
protein coding gene Chr7:29056588-29101376 (-)



Homology
more
  • Human Ortholog
    WDR62, WD repeat domain 62
  • Vertebrate Orthologs
    10
  • Human Ortholog
    WDR62, WD repeat domain 62
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C19orf14, MCPH2
  • Links
    NCBI Gene ID: 284403
    neXtProt AC: NX_O43379
    UniProt: O43379

  • Chr Location
    19q13.12; chr19:36054881-36111145 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Wdr62 mouse models; 1 with human WDR62 associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 2 alleles in 2 genetic backgrounds
    27 images
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice for a hypomorphic allele exhibit reduced brain size due to decreased neural progenitor cells. Cells show spindle instability, spindle assembly checkpoint activation, mitotic arrest and cell death.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037020 Ensembl Gene Model | MGI Sequence Detail 40282 C57BL/6J ±  kb
    transcript ENSMUST00000108190 Ensembl | MGI Sequence Detail 4742 Not Applicable  
    polypeptide ENSMUSP00000103825 Ensembl | MGI Sequence Detail 1524 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • InterPro Domains
      IPR024977 Anaphase-promoting complex subunit 4, WD40 domain
      IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily
      IPR001680 WD40 repeat
      IPR017986 WD40-repeat-containing domain
      IPR036322 WD40-repeat-containing domain superfamily
      IPR015943 WD40/YVTN repeat-like-containing domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 14

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:5437067
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 5
      Phenotypes 12
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:255065 Sgourdou P, et al., Disruptions in asymmetric centrosome inheritance and WDR62-Aurora kinase B interactions in primary microcephaly. Sci Rep. 2017 Mar 8;7:43708

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory