About   Help   FAQ
Wdr62 Gene Detail
Summary
  • Symbol
    Wdr62
  • Name
    WD repeat domain 62
  • Synonyms
    2310038K02Rik, MGC:31423
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923696
    NCBI Gene: 233064
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:29939563-29979844 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 17.34 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    579 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923696
 protein coding gene Chr7:29939563-29980243 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032009
 protein coding gene Chr7:29221106-29265648 (-)
A/J MGP_AJ_G0031986
 protein coding gene Chr7:28451547-28490917 (-)
AKR/J MGP_AKRJ_G0031919
 protein coding gene Chr7:29179231-29222598 (-)
BALB/cJ MGP_BALBcJ_G0031993
 protein coding gene Chr7:28626914-28666303 (-)
C3H/HeJ MGP_C3HHeJ_G0031712
 protein coding gene Chr7:29620537-29664183 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032458
 protein coding gene Chr7:30167424-30209478 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029509
 protein coding gene Chr7:29486592-29527087 (-)
CAST/EiJ MGP_CASTEiJ_G0031046
 protein coding gene Chr7:22873824-22916041 (-)
CBA/J MGP_CBAJ_G0031678
 protein coding gene Chr7:31620584-31672540 (-)
DBA/2J MGP_DBA2J_G0031830
 protein coding gene Chr7:28180283-28219975 (-)
FVB/NJ MGP_FVBNJ_G0031787
 protein coding gene Chr7:28293741-28337859 (-)
LP/J MGP_LPJ_G0031911
 protein coding gene Chr7:29544951-29585104 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031823
 protein coding gene Chr7:30879659-30921209 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032487
 protein coding gene Chr7:28676702-28718122 (-)
PWK/PhJ MGP_PWKPhJ_G0030772
 protein coding gene Chr7:23212283-23254368 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030605
 protein coding gene Chr7:19676421-19722243 (-)
WSB/EiJ MGP_WSBEiJ_G0031156
 protein coding gene Chr7:29056588-29101376 (-)



Homology
more
  • Human Ortholog
    WDR62, WD repeat domain 62
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WDR62, WD repeat domain 62
  • Synonyms
    C19orf14, MCPH2
  • Links
    NCBI Gene ID: 284403
    neXtProt AC: NX_O43379
    UniProt: O43379

  • Chr Location
    19q13.12; chr19:36054649-36111145 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Wdr62 mouse models; 4 with human WDR62 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    42 phenotypes from 4 alleles in 4 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice for a hypomorphic allele exhibit reduced brain size due to decreased neural progenitor cells. Cells show spindle instability, spindle assembly checkpoint activation, mitotic arrest and cell death. Homozygous KO leads to thin cerebral cortex and to male and female infertility owing to germ cell meiotic failures.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    759
  • Tissues
    39
  • cDNA Data
    15
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037020 Ensembl Gene Model | MGI Sequence Detail 40282 C57BL/6J ±  kb
    transcript ENSMUST00000108190 Ensembl | MGI Sequence Detail 4742 Not Applicable  
    polypeptide ENSMUSP00000103825 Ensembl | MGI Sequence Detail 1524 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000032590 WD repeat-containing protein 62
      (term hierarchy)
    • InterPro Domains
      IPR024977 Anaphase-promoting complex subunit 4-like, WD40 domain
      IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily
      IPR001680 WD40 repeat
      IPR036322 WD40-repeat-containing domain superfamily
      IPR015943 WD40/YVTN repeat-like-containing domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 15

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:5437067
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 10
      Diseases 1
      Gene Ontology 7
      Phenotypes 20
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:340108 Xu D, et al., WDR62-deficiency Causes Autism-like Behaviors Independent of Microcephaly in Mice. Neurosci Bull. 2023 Sep;39(9):1333-1347
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory