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Daam2 Gene Detail
Summary
  • Symbol
    Daam2
  • Name
    dishevelled associated activator of morphogenesis 2
  • Synonyms
    2310016D11Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923691
    NCBI Gene: 76441
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr17:49456022-49564343 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      108322 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 25.50 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    DAAM2, dishevelled associated activator of morphogenesis 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    DAAM2, dishevelled associated activator of morphogenesis 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    dJ90A20A.1
  • Links
    NCBI Gene ID: 23500
    neXtProt AC: NX_Q86T65
    UniProt: Q86T65

  • Chr Location
    6p21.2; chr6:39792366-39904877 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotypes from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous KO in combination with homozygous Daam1 conditional KO increases the severity of the heart phenotype (abnormal ventricular morphology and pressure) of the Daam1 single KO.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040260 Ensembl Gene Model | MGI Sequence Detail 108322 C57BL/6J ±  kb
    transcript ENSMUST00000057610 Ensembl | MGI Sequence Detail 3646 Not Applicable  
    polypeptide ENSMUSP00000052085 Ensembl | MGI Sequence Detail 1115 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      983 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 14
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2146931, MGI:2147093
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 15
      Gene Ontology 5
      Phenotypes 10
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:257057 Zhu W, et al., Daam2 driven degradation of VHL promotes gliomagenesis. Elife. 2017 Oct 20;6

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory