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Tufm Gene Detail
Summary
  • Symbol
    Tufm
  • Name
    Tu translation elongation factor, mitochondrial
  • Synonyms
    2300002G02Rik, C76308, EF-TuMT
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923686
    NCBI Gene: 233870
  • Gene Overview
    MyGene.info: TUFM
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:126487361-126490731 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 69.08 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    51 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923686
protein coding gene Chr7:126487354-126490731 (.)
129S1/SvImJ MGP_129S1SvImJ_G0032982
protein coding gene Chr7:130765758-130769128 (+)
A/J MGP_AJ_G0032965
protein coding gene Chr7:127308087-127311671 (+)
AKR/J MGP_AKRJ_G0032897
protein coding gene Chr7:130529692-130533099 (+)
BALB/cJ MGP_BALBcJ_G0032970
protein coding gene Chr7:126964544-126968586 (+)
C3H/HeJ MGP_C3HHeJ_G0032680
protein coding gene Chr7:130455876-130459993 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033476
protein coding gene Chr7:135851569-135857074 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030448
protein coding gene Chr7:128502633-128506097 (+)
CAST/EiJ MGP_CASTEiJ_G0032008
protein coding gene Chr7:122242718-122246137 (+)
CBA/J MGP_CBAJ_G0032653
protein coding gene Chr7:140429114-140433322 (+)
DBA/2J MGP_DBA2J_G0032805
protein coding gene Chr7:125280835-125287473 (+)
FVB/NJ MGP_FVBNJ_G0032758
protein coding gene Chr7:125132385-125135920 (+)
LP/J MGP_LPJ_G0032899
protein coding gene Chr7:132233081-132236538 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032791
protein coding gene Chr7:141617011-141620589 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033496
protein coding gene Chr7:129546451-129549821 (+)
PWK/PhJ MGP_PWKPhJ_G0031716
protein coding gene Chr7:118267756-118271126 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031562
protein coding gene Chr7:116364513-116367912 (+)
WSB/EiJ MGP_WSBEiJ_G0032121
protein coding gene Chr7:130512659-130516030 (+)



Homology
more
  • Human Ortholog
    TUFM, Tu translation elongation factor, mitochondrial
  • Vertebrate Orthologs
    8
  • Human Ortholog
    TUFM, Tu translation elongation factor, mitochondrial
    Orthology source: HomoloGene, HGNC
  • Synonyms
    COXPD4, EFTU, EF-TuMT, P43
  • Links
    NCBI Gene ID: 7284
    neXtProt AC: NX_P49411
    UniProt: P49411

  • Chr Location
    16p11.2; chr16:28842411-28859562 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human TUFM associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000073838 Ensembl Gene Model | MGI Sequence Detail 3371 C57BL/6J ±  kb
transcript ENSMUST00000098048 Ensembl | MGI Sequence Detail 1679 Not Applicable  
polypeptide ENSMUSP00000095656 Ensembl | MGI Sequence Detail 452 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000016832 elongation factor Tu, mitochondrial
  • InterPro Domains
    IPR033720 Elongation factor Tu, domain 2
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR000795 Transcription factor, GTP-binding domain
    IPR009001 Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal
    IPR004541 Translation elongation factor EFTu/EF1A, bacterial/organelle
    IPR004160 Translation elongation factor EFTu/EF1A, C-terminal
    IPR004161 Translation elongation factor EFTu-like, domain 2
    IPR009000 Translation protein, beta-barrel domain superfamily
    IPR031157 Tr-type G domain, conserved site
Molecular
Reagents
less
  • All nucleic 81
    cDNA 81

    Microarray probesets 6
Other
Accession IDs
less
MGI:2142303, MGI:2142305
References
more
  • Summaries
    All 40
    Developmental Gene Expression 1
    Gene Ontology 10
    Phenotypes 8
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:187408 Lei Y, et al., The mitochondrial proteins NLRX1 and TUFM form a complex that regulates type I interferon and autophagy. Immunity. 2012 Jun 29;36(6):933-46

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory