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Tufm Gene Detail
Summary
  • Symbol
    Tufm
  • Name
    Tu translation elongation factor, mitochondrial
  • Synonyms
    2300002G02Rik, C76308, EF-TuMT
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923686
    NCBI Gene: 233870
  • Gene Overview
    MyGene.info: TUFM
Location & Maps
more
  • Sequence Map
    Chr7:126487361-126490731 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3371 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    TUFM, Tu translation elongation factor, mitochondrial
  • Vertebrate Orthologs
    8
  • Human Ortholog
    TUFM, Tu translation elongation factor, mitochondrial
    Orthology source: HomoloGene
  • Synonyms
    COXPD4, EFTU, EF-TuMT, P43
  • Links
    NCBI Gene ID: 7284
    neXtProt AC: NX_P49411

  • Chr Location
    16p11.2; chr16:28842411-28846511 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human TUFM associations

Human Disease Mouse Models
       Combined Oxidative Phosphorylation Deficiency 4; COXPD4   OMIM: 610678
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotype references
  • All Mutations and Alleles
    9
  • Gene trapped
    5
  • Targeted
    4
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000058216 VEGA Gene Model | MGI Sequence Detail 3371 C57BL/6J ±  kb
transcript OTTMUST00000142968 VEGA | MGI Sequence Detail 1679 Not Applicable  
polypeptide OTTMUSP00000074556 VEGA | MGI Sequence Detail 452 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    51 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • InterPro Domains
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR000795 Transcription factor, GTP-binding domain
    IPR009001 Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal
    IPR004541 Translation elongation factor EFTu/EF1A, bacterial/organelle
    IPR004160 Translation elongation factor EFTu/EF1A, C-terminal
    IPR004161 Translation elongation factor EFTu/EF1A, domain 2
    IPR009000 Translation protein, beta-barrel domain
    IPR031157 Tr-type G domain, conserved site
Molecular
Reagents
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  • All nucleic 79
    cDNA 79

    Microarray probesets 6
Other
Accession IDs
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MGI:2142303, MGI:2142305
References
more
  • Summaries
    All 36
    Developmental Gene Expression 1
    Gene Ontology 9
    Phenotypes 7
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory