About   Help   FAQ
Pifo
Gene Detail
 Symbol
Name
ID
Pifo
primary cilia formation
MGI:1923670
Synonyms 1700027A23Rik, pitchfork
Feature Type protein coding gene
Genetic Map
Chromosome 3
46.47 cM, cytoband F3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:105996957-106014646 bp, - strand
From NCBI annotation of GRCm38

  17690 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:18759  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 2 dog

Gene Tree: Pifo

Human
homologs
Human Homolog PIFO, primary cilia formation
NCBI Gene ID 128344
neXtProt AC  NX_Q8TCI5
Human Synonyms  C1orf88, pitchfork
Human Chr (Location)  1p13.2; chr1:111324663-111353017 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from APF )
 
Male mice chimeric for a null allele of this gene are infertile. Heterozygous null embryos generated by tetraploid complementation display embryonic lethality during organogenesis with double outlet heart right ventricle, duplicated cilia and defects in cilia disassembly.
 
Interactions
Pifo interacts with 19 markers (Mir10a, Mir10b, Mir208b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process cell projection organization, positive regulation of kinase activity, ...
Component ciliary basal body, cytoplasm, ...
Function beta-tubulin binding, gamma-tubulin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (51)    Tissues (5)    Images (22)
Theiler Stages: 11, 13, 23
Assay TypeResults
RNA in situ 51
cDNA source data(8)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(8) cDNA(8)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000010136 (Evidence)
Entrez Gene100503311 (Evidence)
UniGene386825
DFCITC1587340
DoTSDT.101345460, DT.40140360
NIA Mouse Gene IndexU024481
Consensus CDS ProjectCCDS51037.1, CCDS51038.1
International Mouse Knockout Project StatusPifo
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 100503311 NCBI Gene Model | MGI Sequence Detail 17690 C57BL/6J ±  kb
transcript NM_001200028 RefSeq | MGI Sequence Detail 973 C57BL/6 
polypeptide Q9D9W1 UniProt | EBI | MGI Sequence Detail 207 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(4) UniProt(1)
Polymorphisms SNPs within 2kb(52 from dbSNP Build 137)    SNPs within 2kb including multiple locations(56)
Protein-related
information
ResourceIDDescription
InterPro IPR010736 Sperm-tail PG-rich repeat
Protein Ontology PR:000029134 protein pitchfork
Graphical View of Protein Domain Structure
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(29)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/23/2014
MGI 5.19
The Jackson Laboratory