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Pifo
Gene Detail
Symbol

Name
ID
Pifo
primary cilia formation
MGI:1923670
Synonyms
1700027A23Rik, pitchfork
Feature Type
protein coding gene
Genetic Map
Chromosome 3
46.47 cM, cytoband F3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:105996957-106014646 bp, - strand
From VEGA annotation of GRCm38

  17690 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:18759  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 2 dog

HCOP human homology predictions: PIFO
Gene Tree: Pifo

Human
homologs
PIFO, primary cilia formation
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 128344
neXtProt AC: NX_Q8TCI5

Human Synonyms: C1orf88, pitchfork

Human Chr (Location): 1p13.2; chr1:111324515-111353017 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from APF )
 
Male mice chimeric for a null allele of this gene are infertile. Heterozygous null embryos generated by tetraploid complementation display embryonic lethality during organogenesis with double outlet heart right ventricle, duplicated cilia and defects in cilia disassembly.
 
Interactions
Pifo interacts with 19 markers (Mir10a, Mir10b, Mir208b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process cell projection organization, positive regulation of kinase activity, ...
Component ciliary basal body, cytoplasm, ...
Function beta-tubulin binding, gamma-tubulin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (51)    Tissues (5)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 51
cDNA source data(8)
Other mouse links: GEO   Expression Atlas
Molecular
reagents
All nucleic(8) cDNA(8)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000052519 (Evidence)
Ensembl Gene Model ENSMUSG00000010136 (Evidence)
Entrez Gene 100503311 (Evidence)
UniGene 386825
DFCI TC1587340
DoTS DT.101345460, DT.40140360
NIA Mouse Gene Index U024481
Consensus CDS Project CCDS51037.1, CCDS51038.1
International Mouse Phenotyping Consortium Status Pifo
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000052519 VEGA Gene Model | MGI Sequence Detail 17690 C57BL/6J ±  kb
transcript OTTMUST00000131702 VEGA | MGI Sequence Detail 956 Not Applicable 
polypeptide OTTMUSP00000070370 VEGA | MGI Sequence Detail 246 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(52 from dbSNP Build 137)    SNPs within 2kb including multiple locations(56)
Protein-related
information
ResourceIDDescription
InterPro IPR010736 Sperm-tail PG-rich repeat
Protein Ontology PR:000029134 protein pitchfork
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(29)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory