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Abcc3 Gene Detail
Summary
  • Symbol
    Abcc3
  • Name
    ATP-binding cassette, sub-family C (CFTR/MRP), member 3
  • Synonyms
    1700019L09Rik, MRP3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923658
    NCBI Gene: 76408
  • Gene Overview
    MyGene.info: ABCC3
Location & Maps
more
  • Sequence Map
    Chr11:94343298-94392997 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      49700 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    ABCC3, ATP binding cassette subfamily C member 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ABCC3, ATP binding cassette subfamily C member 3
    Orthology source: HomoloGene
  • Synonyms
    ABC31, cMOAT2, EST90757, MLP2, MOAT-D, MRP3
  • Links
    NCBI Gene ID: 8714
    neXtProt AC: NX_O15438

  • Chr Location
    17q22; chr17:50634843-50691704 (+)  GRCh38.p2

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 3 genetic backgrounds
    5 phenotypes from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Targeted
    9
  • Transgenic
    2
  • Genomic Mutations
    3 involving Abcc3
  • Incidental Mutations
Mice homozygous for disruptions in this gene exhibit increased liver bile acid levels after bile duct ligation
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001891 VEGA Gene Model | MGI Sequence Detail 49700 C57BL/6J ±  kb
transcript OTTMUST00000003816 VEGA | MGI Sequence Detail 4999 Not Applicable  
polypeptide OTTMUSP00000001838 VEGA | MGI Sequence Detail 1522 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    436 from dbSNP Build 142
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000003559 canalicular multispecific organic anion transporter 2
  • InterPro Domains
    IPR003593 AAA+ ATPase domain
    IPR017871 ABC transporter, conserved site
    IPR003439 ABC transporter-like
    IPR011527 ABC transporter type 1, transmembrane domain
    IPR030242 Canalicular multispecific organic anion transporter 2
    IPR005292 Multi drug resistance-associated protein
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
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  • All nucleic 29
    cDNA 29

    Microarray probesets 3
References
more
  • Summaries
    All 46
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 5
    Phenotypes 21
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:227211 Zhang Y, et al., Maternal bile acid transporter deficiency promotes neonatal demise. Nat Commun. 2015;6:8186

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory