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Abcc3 Gene Detail
Summary
  • Symbol
    Abcc3
  • Name
    ATP-binding cassette, sub-family C (CFTR/MRP), member 3
  • Synonyms
    1700019L09Rik, MRP3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923658
    NCBI Gene: 76408
  • Gene Overview
    MyGene.info: ABCC3
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr11:94343298-94392997 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      49700 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 58.90 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    ABCC3, ATP binding cassette subfamily C member 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ABCC3, ATP binding cassette subfamily C member 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ABC31, cMOAT2, EST90757, MLP2, MOAT-D, MRP3
  • Links
    NCBI Gene ID: 8714
    neXtProt AC: NX_O15438
    UniProt: O15438

  • Chr Location
    17q21.33; chr17:50634843-50691704 (+)  GRCh38.p7

Human Diseases
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  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 3 genetic backgrounds
    5 phenotypes from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene exhibit increased liver bile acid levels after bile duct ligation
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000001891 VEGA Gene Model | MGI Sequence Detail 49700 C57BL/6J ±  kb
    transcript OTTMUST00000003816 VEGA | MGI Sequence Detail 4999 Not Applicable  
    polypeptide OTTMUSP00000001838 VEGA | MGI Sequence Detail 1522 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      436 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • InterPro Domains
      IPR003593 AAA+ ATPase domain
      IPR017871 ABC transporter, conserved site
      IPR003439 ABC transporter-like
      IPR011527 ABC transporter type 1, transmembrane domain
      IPR036640 ABC transporter type 1, transmembrane domain superfamily
      IPR005292 Multi drug resistance-associated protein
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Molecular
    Reagents
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    • All nucleic 30
      cDNA 30

      Microarray probesets 3
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 4
      Diseases 2
      Gene Ontology 7
      Phenotypes 21
    • Earliest
      J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
    • Latest
      J:263646 Horiuchi K, et al., Impaired Spermatogenesis, Muscle, and Erythrocyte Function in U12 Intron Splicing-Defective Zrsr1 Mutant Mice. Cell Rep. 2018 Apr 3;23(1):143-155

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    10/16/2018
    MGI 6.12
    The Jackson Laboratory