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Abcc3
Gene Detail
Symbol

Name
ID
Abcc3
ATP-binding cassette, sub-family C (CFTR/MRP), member 3
MGI:1923658
Synonyms
1700019L09Rik, MRP3
Feature Type
protein coding gene
Genetic Map
Chromosome 11
58.90 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr11:94343298-94392997 bp, - strand
From VEGA annotation of GRCm38

  49700 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68364  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Abcc3

Human
homologs
Human Homolog ABCC3, ATP-binding cassette, sub-family C (CFTR/MRP), member 3
NCBI Gene ID 8714
neXtProt AC  NX_O15438
Human Synonyms  ABC31, cMOAT2, EST90757, MLP2, MOAT-D, MRP3
Human Chr (Location)  17q22; chr17:50634844-50691702 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(8)
Genomic Mutations involving Abcc3 (2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene exhibit increased liver bile acid levels after bile duct ligation
 
Alleles Annotated to Human Diseases(1)   
Interactions
Abcc3 interacts with 79 markers (Mir17, Mir20b, Mir24-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (94)    Tissues (94)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(29)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(29) cDNA(29)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000001891 (Evidence)
Ensembl Gene ModelENSMUSG00000020865 (Evidence)
Entrez Gene76408 (Evidence)
UniGene23942
DFCITC1581183
DoTSDT.101146460, DT.101286092, DT.487605, DT.110528259, DT.94220687
NIA Mouse Gene IndexU033278
Consensus CDS ProjectCCDS25254.1
International Mouse Knockout Project StatusAbcc3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001891 VEGA Gene Model | MGI Sequence Detail 49700 C57BL/6J ±  kb
transcript OTTMUST00000003816 VEGA | MGI Sequence Detail 4999 Not Applicable 
polypeptide OTTMUSP00000001838 VEGA | MGI Sequence Detail 1522 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(4) UniProt(7)
Polymorphisms
SNPs within 2kb(439 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003593 AAA+ ATPase domain
InterPro IPR017871 ABC transporter, conserved site
InterPro IPR003439 ABC transporter-like
InterPro IPR001140 ABC transporter, transmembrane domain
InterPro IPR011527 ABC transporter, transmembrane domain, type 1
InterPro IPR005292 Multi drug resistance-associated protein
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000003559 canalicular multispecific organic anion transporter 2
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:199245 Vergnes L, et al., Diet1 functions in the FGF15/19 enterohepatic signaling axis to modulate bile acid and lipid levels. Cell Metab. 2013 Jun 4;17(6):916-28
All references(49)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory