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Abcc3
Gene Detail
Symbol

Name
ID
Abcc3
ATP-binding cassette, sub-family C (CFTR/MRP), member 3
MGI:1923658
Synonyms
1700019L09Rik, MRP3
Feature Type
protein coding gene
Genetic Map
Chromosome 11
58.90 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr11:94343298-94392997 bp, - strand
From VEGA annotation of GRCm38

  49700 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68364  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: ABCC3
Gene Tree: Abcc3

Human
homologs
ABCC3, ATP-binding cassette, sub-family C (CFTR/MRP), member 3
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 8714
neXtProt AC: NX_O15438

Human Synonyms: ABC31, cMOAT2, EST90757, MLP2, MOAT-D, MRP3

Human Chr (Location): 17q22; chr17:50634843-50691704 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Targeted(9) Transgenic(1)
Genomic Mutations involving Abcc3 (3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene exhibit increased liver bile acid levels after bile duct ligation
 
Mutations Annotated to Human Diseases (1)   
Interactions
Abcc3 interacts with 79 markers (Mir17, Mir20b, Mir24-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (94)    Tissues (94)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(29)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA ABCC3 ; Xenbase abcc3    NEW 
Molecular
reagents
All nucleic(29) cDNA(29)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000001891 (Evidence)
Ensembl Gene Model ENSMUSG00000020865 (Evidence)
Entrez Gene 76408 (Evidence)
UniGene 23942
DFCI TC1581183
DoTS DT.101146460, DT.101286092, DT.110528259, DT.487605, DT.94220687
NIA Mouse Gene Index U033278
Consensus CDS Project CCDS25254.1
International Mouse Phenotyping Consortium Status Abcc3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001891 VEGA Gene Model | MGI Sequence Detail 49700 C57BL/6J ±  kb
transcript OTTMUST00000003816 VEGA | MGI Sequence Detail 4999 Not Applicable 
polypeptide OTTMUSP00000001838 VEGA | MGI Sequence Detail 1522 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(5) UniProt(4)
Polymorphisms
SNPs within 2kb(439 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003593 AAA+ ATPase domain
InterPro IPR017871 ABC transporter, conserved site
InterPro IPR003439 ABC transporter-like
InterPro IPR011527 ABC transporter type 1, transmembrane domain
InterPro IPR030242 Canalicular multispecific organic anion transporter 2
InterPro IPR005292 Multi drug resistance-associated protein
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000003559 canalicular multispecific organic anion transporter 2
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:222957 Vasilyeva A, et al., Hepatocellular Shuttling and Recirculation of Sorafenib-Glucuronide Is Dependent on Abcc2, Abcc3, and Oatp1a/1b. Cancer Res. 2015 Jul 1;75(13):2729-36
All references(48)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory