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Ropn1 Gene Detail
Summary
  • Symbol
    Ropn1
  • Name
    ropporin, rhophilin associated protein 1
  • Synonyms
    1700008N21Rik, ODF6, RHPNAP1, ropporin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923628
    NCBI Gene: 76378
Location & Maps
more
  • Sequence Map
    Chr16:34649921-34678618 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      28698 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 24.44 cM, cytoband B3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ROPN1, rhophilin associated tail protein 1
  • Vertebrate Orthologs
    6
  • Human Ortholog
    ROPN1, rhophilin associated tail protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CT91, ODF6, RHPNAP1, ROPN1A, ropporin
  • Links
    NCBI Gene ID: 54763
    neXtProt AC: NX_Q9HAT0

  • Chr Location
    3q21.1; chr3:123969006-123992170 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit reduced sperm motility and reduced male fertility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026547 VEGA Gene Model | MGI Sequence Detail 28698 C57BL/6J ±  kb
transcript OTTMUST00000065678 VEGA | MGI Sequence Detail 875 Not Applicable  
polypeptide OTTMUSP00000032764 VEGA | MGI Sequence Detail 212 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    130 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    cDNA 12

    Microarray probesets 3
References
more
  • Summaries
    All 25
    Gene Ontology 4
    Phenotypes 4
  • Earliest
    J:69446 Fujita A, et al., Ropporin, a sperm-specific binding protein of rhophilin, that is localized in the fibrous sheath of sperm flagella. J Cell Sci. 2000 Jan;113(Pt 1):103-12
  • Latest
    J:206637 Fiedler SE, et al., Loss of R2D2 proteins ROPN1 and ROPN1L causes defects in murine sperm motility, phosphorylation, and fibrous sheath integrity. Biol Reprod. 2013 Feb;88(2):41

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory