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Ropn1 Gene Detail
Summary
  • Symbol
    Ropn1
  • Name
    ropporin, rhophilin associated protein 1
  • Synonyms
    1700008N21Rik, ODF6, RHPNAP1, ropporin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923628
    NCBI Gene: 76378
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:34649921-34678618 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 24.44 cM, cytoband B3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    130 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923628
protein coding gene Chr16:34649840-34678618 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022762
protein coding gene Chr16:32930487-32960681 (+)
A/J MGP_AJ_G0022727
protein coding gene Chr16:31324083-31354618 (+)
AKR/J MGP_AKRJ_G0022700
protein coding gene Chr16:32426660-32460503 (+)
BALB/cJ MGP_BALBcJ_G0022729
protein coding gene Chr16:31447843-31478467 (+)
C3H/HeJ MGP_C3HHeJ_G0022494
protein coding gene Chr16:32566296-32595456 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023178
protein coding gene Chr16:33637117-33666139 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020696
protein coding gene Chr16:31673796-31702412 (+)
CAST/EiJ MGP_CASTEiJ_G0022022
protein coding gene Chr16:32762976-32794413 (+)
CBA/J MGP_CBAJ_G0022464
protein coding gene Chr16:35008265-35041737 (+)
DBA/2J MGP_DBA2J_G0022597
protein coding gene Chr16:31156832-31185745 (+)
FVB/NJ MGP_FVBNJ_G0022572
protein coding gene Chr16:31148210-31178036 (+)
LP/J MGP_LPJ_G0022664
protein coding gene Chr16:32629179-32662620 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022591
protein coding gene Chr16:34323566-34368591 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023190
protein coding gene Chr16:32461278-32492423 (+)
PWK/PhJ MGP_PWKPhJ_G0021763
protein coding gene Chr16:31540421-31572739 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021594
protein coding gene Chr16:32283491-32312052 (+)
WSB/EiJ MGP_WSBEiJ_G0022066
protein coding gene Chr16:32410243-32441274 (+)



Homology
more
  • Human Ortholog
    ROPN1, rhophilin associated tail protein 1
  • Vertebrate Orthologs
    6
  • Human Ortholog
    ROPN1, rhophilin associated tail protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CT91, ODF6, RHPNAP1, ROPN1A, ropporin
  • Links
    NCBI Gene ID: 54763
    neXtProt AC: NX_Q9HAT0
    UniProt: Q9HAT0

  • Chr Location
    3q21.1; chr3:123969006-123992170 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit reduced sperm motility and reduced male fertility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022832 Ensembl Gene Model | MGI Sequence Detail 28698 C57BL/6J ±  kb
transcript ENSMUST00000023530 Ensembl | MGI Sequence Detail 875 Not Applicable  
polypeptide ENSMUSP00000023530 Ensembl | MGI Sequence Detail 212 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 13
    cDNA 13

    Microarray probesets 3
References
more
  • Summaries
    All 29
    Gene Ontology 6
    Phenotypes 4
  • Earliest
    J:69446 Fujita A, et al., Ropporin, a sperm-specific binding protein of rhophilin, that is localized in the fibrous sheath of sperm flagella. J Cell Sci. 2000 Jan;113(Pt 1):103-12
  • Latest
    J:243457 Zhang X, et al., FSCB phosphorylation regulates mouse spermatozoa capacitation through suppressing SUMOylation of ROPN1/ROPN1L. Am J Transl Res. 2016;8(6):2776-82

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory