About   Help   FAQ
Trmt5 Gene Detail
Summary
  • Symbol
    Trmt5
  • Name
    TRM5 tRNA methyltransferase 5
  • Synonyms
    2610027O18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923607
    NCBI Gene: 76357
Location & Maps
more
  • Sequence Map
    Chr12:73280410-73286711 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6302 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 30.42 cM, cytoband D1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TRMT5, tRNA methyltransferase 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TRMT5, tRNA methyltransferase 5
    Orthology source: HomoloGene
  • Synonyms
    COXPD26, KIAA1393, TRM5
  • Links
    NCBI Gene ID: 57570
    neXtProt AC: NX_Q32P41

  • Chr Location
    14q23.1; chr14:60971441-60981170 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 6096
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: TRMT5
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human TRMT5 associations

Human Disease Mouse Models
       Combined Oxidative Phosphorylation Deficiency 26; COXPD26   OMIM: 616539
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Gene trapped
    5
  • Targeted
    3
  • Genomic Mutations
    1 involving Trmt5
  • Incidental Mutations
    APF , CvDC
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000034442 Ensembl Gene Model | MGI Sequence Detail 6302 C57BL/6J ±  kb
transcript ENSMUST00000116420 Ensembl | MGI Sequence Detail 1669 Not Applicable  
polypeptide ENSMUSP00000112121 Ensembl | MGI Sequence Detail 501 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    79 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000016682 tRNA (guanine-N(1)-)-methyltransferase
  • EC
  • InterPro Domains
    IPR029063 S-adenosyl-L-methionine-dependent methyltransferase
    IPR030382 SAM-dependent methyltransferase TRM5/TYW2-type
    IPR025792 tRNA (guanine(37)-N(1))-methyltransferase, eukaryotic
Molecular
Reagents
less
  • All nucleic 32
    cDNA 32

    Microarray probesets 3
References
more
  • Summaries
    All 25
    Gene Ontology 4
    Phenotypes 6
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/12/2016
MGI 6.04
The Jackson Laboratory