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Rars2 Gene Detail
Summary
  • Symbol
    Rars2
  • Name
    arginyl-tRNA synthetase 2, mitochondrial
  • Synonyms
    1500002I10Rik, PRO1992, Rarsl
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923596
    NCBI Gene: 109093
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr4:34614957-34660167 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      45211 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 16.84 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    RARS2, arginyl-tRNA synthetase 2, mitochondrial
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RARS2, arginyl-tRNA synthetase 2, mitochondrial
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ArgRS, DALRD2, PCH6, PRO1992, RARSL
  • Links
    NCBI Gene ID: 57038
    neXtProt AC: NX_Q5T160
    UniProt: Q5T160

  • Chr Location
    6q15; chr6:87513744-87590032 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 5707
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: RARS2
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human RARS2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000006415 VEGA Gene Model | MGI Sequence Detail 45211 C57BL/6J ±  kb
    transcript OTTMUST00000014627 VEGA | MGI Sequence Detail 1868 Not Applicable  
    polypeptide OTTMUSP00000006801 VEGA | MGI Sequence Detail 578 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      239 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000031350 arginine--tRNA ligase, mitochondrial
    • EC
    • InterPro Domains
      IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-binding
      IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site
      IPR001278 Arginine-tRNA ligase
      IPR035684 Arginyl-tRNA synthetase, catalytic core domain
      IPR036695 Arginyl tRNA synthetase N-terminal domain superfamily
      IPR008909 DALR anticodon binding
      IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
    Molecular
    Reagents
    less
    • All nucleic 65
      cDNA 65

      Microarray probesets 3
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 2
      Gene Ontology 4
      Phenotypes 9
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory