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Exosc4 Gene Detail
Summary
  • Symbol
    Exosc4
  • Name
    exosome component 4
  • Synonyms
    1110039I09Rik, 1500001N04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923576
    NCBI Gene: 109075
  • Gene Overview
    MyGene.info: EXOSC4
Location & Maps
more
  • Sequence Map
    Chr15:76327397-76330677 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3281 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    EXOSC4, exosome component 4
  • Vertebrate Orthologs
    9
  • Human Ortholog
    EXOSC4, exosome component 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    hRrp41p, p12A, RRP41, RRP41A, Rrp41p, SKI6, Ski6p
  • Links
    NCBI Gene ID: 54512
    neXtProt AC: NX_Q9NPD3

  • Chr Location
    8q24.3; chr8:144064087-144080648 (+)  GRCh38.p2

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotype references
  • All Mutations and Alleles
    14
  • Chemically induced (other)
    3
  • Gene trapped
    7
  • Radiation induced
    2
  • Targeted
    2
  • Genomic Mutations
    5 involving Exosc4
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035760 VEGA Gene Model | MGI Sequence Detail 3281 C57BL/6J ±  kb
transcript OTTMUST00000091479 VEGA | MGI Sequence Detail 1796 Not Applicable  
polypeptide OTTMUSP00000050392 VEGA | MGI Sequence Detail 245 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    26 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000007261 exosome complex component RRP41
  • InterPro Domains
    IPR001247 Exoribonuclease, phosphorolytic domain 1
    IPR015847 Exoribonuclease, phosphorolytic domain 2
    IPR027408 PNPase/RNase PH domain
    IPR020568 Ribosomal protein S5 domain 2-type fold
Molecular
Reagents
less
  • All nucleic 81
    cDNA 81

    Microarray probesets 3
Other
Accession IDs
less
MGI:1916201
References
more
  • Summaries
    All 26
    Diseases 1
    Gene Ontology 5
    Phenotypes 25
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:175771 Miyashita M, et al., DDX60, a DEXD/H Box Helicase, Is a Novel Antiviral Factor Promoting RIG-I-Like Receptor-Mediated Signaling. Mol Cell Biol. 2011 Sep;31(18):3802-19

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory