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Exosc4
Gene Detail
 Symbol
Name
ID
Exosc4
exosome component 4
MGI:1923576
Synonyms 1110039I09Rik, 1500001N04Rik
Feature Type protein coding gene
Genetic Map
Chromosome 15
35.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr15:76327397-76330677 bp, + strand
From VEGA annotation of GRCm38

  3281 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:6017  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: tRNA nucleotidyltransferase
Gene Tree: Exosc4

Human
homologs
Human Homolog EXOSC4, exosome component 4
NCBI Gene ID 54512
neXtProt AC  NX_Q9NPD3
Human Synonyms  hRrp41p, p12A, RRP41, RRP41A, Rrp41p, SKI6, Ski6p
Human Chr (Location)  8q24.3; chr8:144078619-144080648 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(7) Radiation induced(1) Targeted(2)
Genomic Mutations involving Exosc4 (1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Exosc4 interacts with 109 markers (Mir10a, Mir10b, Mir18, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process defense response to virus, DNA deamination, ...
Component cytoplasm, exosome (RNase complex), ...
Function AU-rich element binding, protein binding, ...
External Resources: FuncBase
Expression
cDNA source data(80)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(81) cDNA(81)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000035760 (Evidence)
Ensembl Gene ModelENSMUSG00000034259 (Evidence)
Entrez Gene109075 (Evidence)
UniGene322752
DFCITC1575645
NIA Mouse Gene IndexU016362
Consensus CDS ProjectCCDS37119.1
International Mouse Knockout Project StatusExosc4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035760 VEGA Gene Model | MGI Sequence Detail 3281 C57BL/6J ±  kb
transcript OTTMUST00000091479 VEGA | MGI Sequence Detail 1796 Not Applicable 
polypeptide OTTMUSP00000050392 VEGA | MGI Sequence Detail 245 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(26 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001247 Exoribonuclease, phosphorolytic domain 1
InterPro IPR015847 Exoribonuclease, phosphorolytic domain 2
InterPro IPR027408 PNPase/RNase PH domain
InterPro IPR020568 Ribosomal protein S5 domain 2-type fold
Protein Ontology PR:000007261 exosome complex component RRP41
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:175771 Miyashita M, et al., DDX60, a DEXD/H Box Helicase, Is a Novel Antiviral Factor Promoting RIG-I-Like Receptor-Mediated Signaling. Mol Cell Biol. 2011 Sep;31(18):3802-19
All references(29)
Other
accession IDs
MGI:1916201

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory