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Dnaaf2
Gene Detail
 Symbol
Name
ID
Dnaaf2
dynein, axonemal assembly factor 2
MGI:1923566
Synonyms 1110034A24Rik, 2810020C19Rik, kintoun, Ktu
Feature Type protein coding gene
Genetic Map
Chromosome 12
28.73 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr12:69189087-69198429 bp, - strand
From VEGA annotation of GRCm38

  9343 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10026  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Dnaaf2

Human
homologs
Human Homolog DNAAF2, dynein, axonemal, assembly factor 2
NCBI Gene ID 55172
neXtProt AC  NX_Q9NVR5
Human Synonyms  C14orf104, CILD10, KTU, PF13
Human Chr (Location)  14q21.3; chr14:49625174-49635230 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human DNAAF2
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(2) Targeted(3)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele exhibit postnatal lethality, reduced body size, situs inversus totalis, hydroencephaly and abnormal brain ependymal and tracheal cilia morphology and motility.
 
Interactions
Dnaaf2 interacts with 89 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process axonemal dynein complex assembly, bacterial-type flagellum-dependent cell motility, ...
Component ciliary basal body, cytoplasm
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (125)    Tissues (22)    Images (24)
Theiler Stages: 18, 20, 23
Assay TypeResults
RNA in situ 125
cDNA source data(39)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(40) cDNA(39) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000023796 (Evidence)
Ensembl Gene ModelENSMUSG00000020973 (Evidence)
Entrez Gene109065 (Evidence)
UniGene107180
DFCITC1577411, TC1601928
NIA Mouse Gene IndexU034030
Consensus CDS ProjectCCDS25948.1
International Mouse Knockout Project StatusDnaaf2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023796 VEGA Gene Model | MGI Sequence Detail 9343 C57BL/6J ±  kb
transcript OTTMUST00000058147 VEGA | MGI Sequence Detail 3390 Not Applicable 
polypeptide OTTMUSP00000028128 VEGA | MGI Sequence Detail 814 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(93 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012981 PIH
Protein Ontology PR:000009596 protein kintoun
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:201474 Matsuo M, et al., The establishment of rotational polarity in the airway and ependymal cilia: analysis with a novel cilium motility mutant mouse. Am J Physiol Lung Cell Mol Physiol. 2013 Jun 1;304(11):L736-45
All references(37)
Other
accession IDs
MGI:1917189, MGI:2144978

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory