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Steap4
Gene Detail
Symbol

Name
ID
Steap4
STEAP family member 4
MGI:1923560
Synonyms
1110021O17Rik, Tiarp, Tnfaip9
Feature Type
protein coding gene
Genetic Map
Chromosome 5
3.37 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr5:7960457-7982213 bp, + strand
From VEGA annotation of GRCm38

  21757 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:36422  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 western clawed frog; 1 zebrafish

HCOP human homology predictions: STEAP4
Gene Tree: Steap4

Human
homologs
STEAP4, STEAP family member 4
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 79689
neXtProt AC: NX_Q687X5

Human Synonyms: STAMP2, TIARP, TNFAIP9

Human Chr (Location): 7q21.12; chr7:88276429-88306913 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit adipose accumulation, oxidative stress, increased liver weight, lower metabolic rate, hypoactivity, insulin resistance, glucose intolerance, mild hyperglycemia and dyslipidemia.
 
Interactions
Steap4 interacts with 222 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process copper ion import, ferric iron import into cell, ...
Component endosome, extracellular exosome, ...
Function cupric reductase activity, ferric-chelate reductase (NADPH) activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(40)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase steap4    NEW 
Molecular
reagents
All nucleic(40) cDNA(40)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000054267 (Evidence)
Ensembl Gene Model ENSMUSG00000012428 (Evidence)
Entrez Gene 117167 (Evidence)
UniGene 31403
DFCI TC1578216
DoTS DT.529541, DT.91391102, DT.94276974
NIA Mouse Gene Index U025910
EC 1.16.1.-
Consensus CDS Project CCDS39008.1
International Mouse Phenotyping Consortium Status Steap4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000054267 VEGA Gene Model | MGI Sequence Detail 21757 C57BL/6J ±  kb
transcript OTTMUST00000134679 VEGA | MGI Sequence Detail 3155 Not Applicable 
polypeptide OTTMUSP00000071396 VEGA | MGI Sequence Detail 470 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(218 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013130 Ferric reductase transmembrane component-like domain
InterPro IPR016040 NAD(P)-binding domain
InterPro IPR028939 Pyrroline-5-carboxylate reductase, catalytic, N-terminal
Protein Ontology PR:000015733 metalloreductase STEAP4
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:204547 Zhou J, et al., Steap4 plays a critical role in osteoclastogenesis in vitro by regulating cellular iron/reactive oxygen species (ROS) levels and cAMP response element-binding protein (CREB) activation. J Biol Chem. 2013 Oct 18;288(42):30064-74
All references(35)
Other
accession IDs
MGI:2140915, MGI:2152335

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory