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Phf14
Gene Detail
Symbol

Name
ID
Phf14
PHD finger protein 14
MGI:1923539
Synonyms
1110001C23Rik, 4932409F11Rik, 5730446A07Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 6
5.01 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:11907809-12008081 bp, + strand
From VEGA annotation of GRCm38

  100273 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8775  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PHF14
Gene Tree: Phf14

Human
homologs
PHF14, PHD finger protein 14
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 9678
neXtProt AC: NX_O94880

Human Chr (Location): 7p21.3; chr7:10957892-11169828 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(29) : Gene trapped(28) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit complete neonatal lethality due to respiratory failure, pulmonary wall hypertrophy, abnormal sternum ossification, and increased proliferation of bone marrow-derived mesenchymal cells and mouse embryonic fibroblasts.
 
Interactions
Phf14 interacts with 225 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process lung alveolus development, negative regulation of cell proliferation, ...
Component nucleus
Function metal ion binding, zinc ion binding
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (257)    Tissues (97)    Images (29)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 249
RT-PCR 8
cDNA source data(90)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase phf14    NEW 
Molecular
reagents
All nucleic(91) cDNA(90) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000017311 (Evidence)
Ensembl Gene Model ENSMUSG00000029629 (Evidence)
Entrez Gene 75725 (Evidence)
UniGene 212411
DFCI TC1579615, TC1582883, TC1591699, TC1600436, TC1620578, TC1650222, TC1664088
DoTS DT.101718522, DT.489621, DT.55283471, DT.94326808, DT.94326816, DT.94394034, DT.99842919
NIA Mouse Gene Index U006541, U053699
Consensus CDS Project CCDS39428.1, CCDS51720.1
International Mouse Phenotyping Consortium Status Phf14
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017311 VEGA Gene Model | MGI Sequence Detail 100273 C57BL/6J ±  kb
transcript OTTMUST00000042041 VEGA | MGI Sequence Detail 3353 Not Applicable 
polypeptide OTTMUSP00000018904 VEGA | MGI Sequence Detail 881 Not Applicable 

For the selected sequences
All sequences(79) RefSeq(24) UniProt(4)
Polymorphisms
SNPs within 2kb(823 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011011 Zinc finger, FYVE/PHD-type
InterPro IPR019787 Zinc finger, PHD-finger
InterPro IPR001965 Zinc finger, PHD-type
InterPro IPR019786 Zinc finger, PHD-type, conserved site
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001841 Zinc finger, RING-type
Protein Ontology PR:000012641 PHD finger protein 14
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:184822 Kitagawa M, et al., Phf14, a Novel Regulator of Mesenchyme Growth via Platelet-derived Growth Factor (PDGF) Receptor-alpha. J Biol Chem. 2012 Jun 23;
All references(36)
Other
accession IDs
MGI:1922961, MGI:1922975, MGI:3034353, MGI:3035067

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory