Tax1bp3 MGI Mouse Gene Detail - MGI:1923531 - Tax1 (human T cell leukemia virus type I) binding protein 3

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Tax1bp3 Gene Detail

Symbol

Tax1bp3
Name

Tax1 (human T cell leukemia virus type I) binding protein 3
Synonyms

1300011C24Rik, TIP-1

Feature Type

protein coding gene
IDs

MGI:1923531
NCBI Gene: 76281
Alliance

gene page
Transcription Start Sites

3 TSS
Candidate for QTL

1 QTL

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Sequence Map

Chr11:73067909-73072872 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 45.25 cM
Mapping Data

2 experiments

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SNPs within 2kb

68 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates	Select Strains
C57BL/6J	MGI_C57BL6J_1923531	protein coding gene	Chr11:73067909-73073988 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018655	protein coding gene	Chr11:73856056-73864525 (+)
A/J	MGP_AJ_G0018623	protein coding gene	Chr11:71083607-71090584 (+)
AKR/J	MGP_AKRJ_G0018592	protein coding gene	Chr11:73254681-73263595 (+)
BALB/cJ	MGP_BALBcJ_G0018595	protein coding gene	Chr11:71384938-71392853 (+)
C3H/HeJ	MGP_C3HHeJ_G0018408	protein coding gene	Chr11:73206765-73214671 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019046	protein coding gene	Chr11:76105130-76114670 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016689	protein coding gene	Chr11:67890099-67895990 (+)
CAST/EiJ	MGP_CASTEiJ_G0017963	protein coding gene	Chr11:73590029-73599126 (+)
CBA/J	MGP_CBAJ_G0018380	protein coding gene	Chr11:79455552-79462756 (+)
DBA/2J	MGP_DBA2J_G0018489	protein coding gene	Chr11:70710437-70718739 (+)
FVB/NJ	MGP_FVBNJ_G0018480	protein coding gene	Chr11:70258113-70264142 (+)
LP/J	MGP_LPJ_G0018560	protein coding gene	Chr11:74372930-74379846 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018503	protein coding gene	Chr11:79968763-79977935 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019088	protein coding gene	Chr11:73437801-73444927 (+)
PWK/PhJ	MGP_PWKPhJ_G0017736	protein coding gene	Chr11:71352935-71359064 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017526	protein coding gene	Chr11:73154151-73160709 (+)
WSB/EiJ	MGP_WSBEiJ_G0018017	protein coding gene	Chr11:73185452-73197061 (+)

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Human Ortholog

TAX1BP3, Tax1 binding protein 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TAX1BP3, Tax1 binding protein 3
Synonyms

TIP1, TIP-1
Links

HGNC:30684

NCBI Gene ID: 30851

neXtProt AC: NX_O14907

UniProt: O14907
Chr Location

17p13.2; chr17:3662895-3668679 (-) GRCh38

MGI Vertebrate Homology

Tax1bp3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TAX1BP3
Protein SuperFamily

Tax1-binding_p3
Gene Tree

Tax1bp3

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
16 phenotype references

Phenotype Overview

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Gene trapped

1
Targeted

6
Genomic Mutations

2 involving Tax1bp3
Find Mice (IMSR)

11 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

31
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

1
cDNA Data

66
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tax1bp3

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All Sequences

38
RefSeq

2
UniProt

2
CCDS

CCDS25000.1

Ensembl

ENSMUSG00000040158 (Evidence)
NCBI Gene

76281

Representative Sequences				Length	Strain/Species	Flank
	genomic	76281	NCBI Gene Model \| MGI Sequence Detail	4964	C57BL/6J	± kb
	transcript	NM_029564	RefSeq \| MGI Sequence Detail	1417	C57BL/6
	polypeptide	Q9DBG9	UniProt \| EBI \| MGI Sequence Detail	124	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000016091 Tax1-binding protein 3

(term hierarchy)
PDB

3DIW, 3DJ1, 3DJ3
InterPro Domains

IPR001478 PDZ domain

IPR036034 PDZ superfamily

IPR017268 Tax1-binding protein 3

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All nucleic 69

cDNA 68

Primer pair 1

Microarray probesets 4

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Summaries

All 44

Developmental Gene Expression 1

Gene Ontology 8

Phenotypes 16
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345299 Wang Y, et al., Tax1 binding protein 3 regulates osteogenic and adipogenic differentiation through inactivating Wnt/beta-catenin signalling. J Cell Mol Med. 2023 Apr;27(7):950-961

TSS for Tax1bp3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr102887	Chr11:73067304-73067327 (+)	-593 bp
Tssr102888	Chr11:73068026-73068061 (+)	135 bp
Tssr102889	Chr11:73068062-73068087 (+)	166 bp

Tax1bp3 is Candidate Gene for:

QTL	Genetic Location*	Genome Location (GRCm39)	Reference	QTL Note
Lore4	Chr11, syntenic	Chr11:79156009-107616472	J:105312	Candidate genes for ethanol sensitivity QTL Lore1 (loss of righting induced by ethanol 1), Lore2, Lore4, and Lore5 were identified using Affymetrix gene microarray analysis. RNA from the cerebella of male animals from inbred strains LS and SS were hybridized to 2 different sets of Affymetrix gene chips and analyzed for gene expression differences. The inbred strain LS exhibits increased alcohol sensitivity compared to SS. A total of 15 candidate genes were identified, 4 of which have polymorphisms between LS and SS. Xrcc5 (42 cM) was identified as candidate gene for Lore1 (54 cM) on mouse Chromosome 1. Xrcc5 exhibits 2.5-fold increased expression in the SS inbred strain compared to the LS inbred strain. In addition the human ortholog XRCC5 is also associated with ethanol-induced loss of righting response. Pcsk2 (81.4 cM), Slc22a4 (28 cM), and Rassf2 were identified as candidate genes for Lore2 (85 cM) on mouse Chromosome 2. Pcsk2 and Slc22a4 exhibit 2.9-fold and 2.4-fold increased expression in LS compared to SS, respectively, whereas Rassf2 exhibits 2.4-fold increased expression in SS compared to LS. Two polymorphisms were detected in the promoter region of Slc22a4, one of which disrupts a putative SP-1 transcription factor binding site in the SS sequence. In addition, the human ortholog SLC22A4 is associated with ethanol-induced loss of righting response in humans. Six polymorphisms were detected in the Rassf2 promoter, two of which disrupt putative SP-1 transcription factor binding sites in the SS sequence. Myo1d (46 cM), BG075643 (a cDNA clone), Ebf1 (20 cM), Stx8, Tax1bp3, and Tnfaip1 (45 cM) were identified as candidate genes for Lore4 (49 cM) on mouse Chromosome 11. Myo1d and BG075643 are expressed 6.2-fold higher in LS compared to SS strains.Ebf1 is expressed 2.1-fold higher, Stx8 is expressed 2-fold higher, Tax1bp3 is expressed 2.2-fold higher, and Tnfaip1 is expressed 2-fold higher in SS compared to LS strains. The Stx8 promoter sequence has 2 polymorphisms between LS and SS, and the Tax1bp3 promoter sequence has 4 polymorphisms, one of which results in disruption of a putative NF-kB transcription factor binding site in the LS strain. Cthrc1, Krt2-8 (58.9 cM), Lgals2, Scrt1, and Atf1 were identified as candidate genes for Lore5 (46 cM) onmouse Chromosome 15. Atf1 is expressed 2-fold higher in SS compared to LS strains. Cthrc1 (3.2-fold), Krt2-8 (2.3-fold), Lga1s2 (2-fold), and Scrt1 (2.4-fold) are expressed higher in LS compared to SS strains.

*cM position of peak correlated region/marker

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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