About   Help   FAQ
Ndfip2 Gene Detail
Summary
  • Symbol
    Ndfip2
  • Name
    Nedd4 family interacting protein 2
  • Synonyms
    0710001O20Rik, 9130207N19Rik, N4wbp5a
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923523
    NCBI Gene: 76273
  • Gene Overview
    MyGene.info: NDFIP2
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:105258585-105309298 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 55.64 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    612 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923523
protein coding gene Chr14:105258573-105309298 (.)
129S1/SvImJ MGP_129S1SvImJ_G0021637
protein coding gene Chr14:101838016-101891215 (+)
A/J MGP_AJ_G0021595
protein coding gene Chr14:98465683-98516130 (+)
AKR/J MGP_AKRJ_G0021571
protein coding gene Chr14:101406242-101462835 (+)
BALB/cJ MGP_BALBcJ_G0021601
protein coding gene Chr14:98815740-98866259 (+)
C3H/HeJ MGP_C3HHeJ_G0021379
protein coding gene Chr14:101335730-101388830 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022041
protein coding gene Chr14:105941401-105991455 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019581
protein coding gene Chr14:95232934-95280726 (+)
CAST/EiJ MGP_CASTEiJ_G0020896
protein coding gene Chr14:98662954-98714893 (+)
CBA/J MGP_CBAJ_G0021347
protein coding gene Chr14:109730899-109788744 (+)
DBA/2J MGP_DBA2J_G0021471
protein coding gene Chr14:97961529-98011335 (+)
FVB/NJ MGP_FVBNJ_G0021448
protein coding gene Chr14:96913805-96968891 (+)
LP/J MGP_LPJ_G0021539
protein coding gene Chr14:102663345-102715171 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021475
protein coding gene Chr14:112580986-112641401 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022064
protein coding gene Chr14:100938690-100990883 (+)
PWK/PhJ MGP_PWKPhJ_G0020639
protein coding gene Chr14:94927318-94979588 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020477
protein coding gene Chr14:96936227-96991320 (+)
WSB/EiJ MGP_WSBEiJ_G0020949
protein coding gene Chr14:101564917-101617836 (+)



Homology
more
  • Human Ortholog
    NDFIP2, Nedd4 family interacting protein 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NDFIP2, Nedd4 family interacting protein 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    N4WBP5A
  • Links
    NCBI Gene ID: 54602
    neXtProt AC: NX_Q9NV92
    UniProt: Q9NV92

  • Chr Location
    13q31.1; chr13:79480722-79556077 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 12636
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: NDFIP2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable and exhibit normal hematological parameters. However, when fed a low iron diet, female homozygotes display a decrease in liver iron content and are able to maintain normal serum iron levels and transferrin saturation, unlike wild-type females.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 76273 NCBI Gene Model | MGI Sequence Detail 50714 C57BL/6J ±  kb
    transcript NM_029561 RefSeq | MGI Sequence Detail 2432 C57BL/6  
    polypeptide Q91ZP6 UniProt | EBI | MGI Sequence Detail 311 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • InterPro Domains
      IPR019325 NEDD4/Bsd2
    Molecular
    Reagents
    less
    • All nucleic 17
      Genomic 1
      cDNA 16

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1924402
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 14
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:249835 Trimpert C, et al., NDFIP allows NEDD4/NEDD4L-induced AQP2 ubiquitination and degradation. PLoS One. 2017;12(9):e0183774

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory