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Tsen54
Gene Detail
Symbol

Name
ID
Tsen54
tRNA splicing endonuclease 54 homolog (S. cerevisiae)
MGI:1923515
Synonyms
0610034P02Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 11
80.91 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:115814724-115823094 bp, + strand
From VEGA annotation of GRCm38

  8371 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:35476  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TSEN54
Gene Tree: Tsen54

Human
homologs
TSEN54, TSEN54 tRNA splicing endonuclease subunit
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 283989
neXtProt AC: NX_Q7Z6J9

Human Synonyms: PCH2A, PCH4, PCH5, sen54, SEN54L

Human Chr (Location): 17q25.1; chr17:75515707-75524739 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human TSEN54

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(2) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Tsen54 interacts with 82 markers (Mir7b, Mir22, Mir34a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process mRNA processing, tRNA processing, ...
Component nucleus, tRNA-intron endonuclease complex
Function tRNA-intron endonuclease activity
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (11)    Tissues (6)    Images (7)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 11
cDNA source data(35)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase tsen54 ; ZFIN tsen54    NEW 
Molecular
reagents
All nucleic(36) cDNA(36)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000003539 (Evidence)
Ensembl Gene Model ENSMUSG00000020781 (Evidence)
Entrez Gene 76265 (Evidence)
UniGene 275438
DFCI TC1612895, TC1578521
DoTS DT.97405921, DT.50315678, DT.101282140
NIA Mouse Gene Index U013546
Consensus CDS Project CCDS25648.1
International Mouse Phenotyping Consortium Status Tsen54
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003539 VEGA Gene Model | MGI Sequence Detail 8371 C57BL/6J ±  kb
transcript OTTMUST00000007589 VEGA | MGI Sequence Detail 1979 Not Applicable 
polypeptide OTTMUSP00000003671 VEGA | MGI Sequence Detail 525 Not Applicable 

For the selected sequences
All sequences(68) RefSeq(13) UniProt(5)
Polymorphisms
SNPs within 2kb(60 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024337 tRNA-splicing endonuclease, subunit Sen54
InterPro IPR024336 tRNA-splicing endonuclease, subunit Sen54, N-terminal
Protein Ontology PR:000016717 tRNA-splicing endonuclease subunit Sen54
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(33)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory