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Tsen54
Gene Detail
Symbol

Name
ID
Tsen54
tRNA splicing endonuclease 54 homolog (S. cerevisiae)
MGI:1923515
Synonyms
0610034P02Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 11
80.91 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:115814724-115823094 bp, + strand
From VEGA annotation of GRCm38

  8371 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:35476  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Tsen54

Human
homologs
Human Homolog TSEN54, TSEN54 tRNA splicing endonuclease subunit
NCBI Gene ID 283989
neXtProt AC  NX_Q7Z6J9
Human Synonyms  PCH2A, PCH4, sen54, SEN54L
Human Chr (Location)  17q25.1; chr17:75515707-75524740 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human TSEN54
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(2) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Tsen54 interacts with 82 markers (Mir7b, Mir22, Mir34a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process mRNA processing, tRNA processing, ...
Component nucleus
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (11)    Tissues (6)    Images (7)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 11
cDNA source data(35)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(36) cDNA(36)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000003539 (Evidence)
Ensembl Gene ModelENSMUSG00000020781 (Evidence)
Entrez Gene76265 (Evidence)
UniGene275438
DFCITC1578521, TC1612895
DoTSDT.101282140, DT.50315678, DT.97405921
NIA Mouse Gene IndexU013546
Consensus CDS ProjectCCDS25648.1
International Mouse Knockout Project StatusTsen54
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003539 VEGA Gene Model | MGI Sequence Detail 8371 C57BL/6J ±  kb
transcript OTTMUST00000007589 VEGA | MGI Sequence Detail 1979 Not Applicable 
polypeptide OTTMUSP00000003671 VEGA | MGI Sequence Detail 525 Not Applicable 

For the selected sequences
All sequences(74) RefSeq(16) UniProt(9)
Polymorphisms
SNPs within 2kb(60 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024337 tRNA-splicing endonuclease, subunit Sen54
InterPro IPR024336 tRNA-splicing endonuclease, subunit Sen54, N-terminal
Protein Ontology PR:000016717 tRNA-splicing endonuclease subunit Sen54
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(33)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory