About   Help   FAQ
Tsen54 Gene Detail
Summary
  • Symbol
    Tsen54
  • Name
    tRNA splicing endonuclease subunit 54
  • Synonyms
    0610034P02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923515
    NCBI Gene: 76265
Location & Maps
more
  • Sequence Map
    Chr11:115814724-115823094 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8371 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 80.91 cM, cytoband E2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TSEN54, tRNA splicing endonuclease subunit 54
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TSEN54, tRNA splicing endonuclease subunit 54
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PCH2A, PCH4, PCH5, sen54, SEN54L
  • Links
    NCBI Gene ID: 283989
    neXtProt AC: NX_Q7Z6J9

  • Chr Location
    17q25.1; chr17:75515707-75524739 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 35476
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TSEN54
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with human TSEN54 associations

Human Disease Mouse Models
       Pontocerebellar Hypoplasia, Type 2A; PCH2A   OMIM: 277470
Pontocerebellar Hypoplasia, Type 4; PCH4   OMIM: 225753
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
  • All Mutations and Alleles
    6
  • Gene trapped
    2
  • Targeted
    4
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003539 VEGA Gene Model | MGI Sequence Detail 8371 C57BL/6J ±  kb
transcript OTTMUST00000007589 VEGA | MGI Sequence Detail 1979 Not Applicable  
polypeptide OTTMUSP00000003671 VEGA | MGI Sequence Detail 525 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    64 from dbSNP Build 142
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000016717 tRNA-splicing endonuclease subunit Sen54
  • InterPro Domains
    IPR024337 tRNA-splicing endonuclease, subunit Sen54
    IPR024336 tRNA-splicing endonuclease, subunit Sen54, N-terminal
Molecular
Reagents
less
  • All nucleic 36
    cDNA 36

    Microarray probesets 3
References
more
  • Summaries
    All 29
    Developmental Gene Expression 2
    Gene Ontology 3
    Phenotypes 5
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/29/2016
MGI 6.06
The Jackson Laboratory