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Gstk1
Gene Detail
Symbol

Name
ID
Gstk1
glutathione S-transferase kappa 1
MGI:1923513
Synonyms
0610025I19Rik, DsbA-L
Feature Type
protein coding gene
Genetic Map
Chromosome 6
20.52 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:42245935-42250441 bp, + strand
From NCBI annotation of GRCm38

  4507 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41075  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 western clawed frog; 5 zebrafish

Protein SuperFamily: HCCA isomerase/glutathione S-transferase kappa
Gene Tree: Gstk1

Human
homologs
Human Homolog GSTK1, glutathione S-transferase kappa 1
NCBI Gene ID 373156
neXtProt AC  NX_Q9Y2Q3
Human Synonyms  GST, GST13, GST 13-13, GST13-13, GSTK1-1, hGSTK1
Human Chr (Location)  7q34; chr7:143263429-143269129 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit abnormal male survival curves associated with increased glomerular nephropathy.
 
Interactions
Gstk1 interacts with 35 markers (Mir124a-1, Mir124a-2, Mir124a-3, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(52)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(53) cDNA(52) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000029864 (Evidence)
Entrez Gene76263 (Evidence)
UniGene267014
DFCITC1745076, TC1580117
DoTSDT.535144, DT.94395988
NIA Mouse Gene IndexU006747
EC2.5.1.18
Consensus CDS ProjectCCDS20063.1
International Mouse Knockout Project StatusGstk1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 76263 NCBI Gene Model | MGI Sequence Detail 4507 C57BL/6J ±  kb
transcript NM_029555 RefSeq | MGI Sequence Detail 930 C57BL/6 
polypeptide Q9DCM2 UniProt | EBI | MGI Sequence Detail 226 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(61 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001853 DSBA-like thioredoxin domain
InterPro IPR014440 HCCA isomerase/glutathione S-transferase kappa
InterPro IPR012336 Thioredoxin-like fold
Protein Ontology PR:000008299 glutathione S-transferase kappa 1
Graphical View of Protein Domain Structure
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:177201 Blackburn AC, et al., Glutathione transferase kappa deficiency causes glomerular nephropathy without overt oxidative stress. Lab Invest. 2011 Nov;91(11):1572-83
All references(39)
Other
accession IDs
MGI:2139339

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory