About   Help   FAQ
Gstk1 Gene Detail
Summary
  • Symbol
    Gstk1
  • Name
    glutathione S-transferase kappa 1
  • Synonyms
    0610025I19Rik, DsbA-L
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923513
    NCBI Gene: 76263
  • Gene Overview
    MyGene.info: GSTK1
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:42245935-42250441 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 20.52 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    61 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923513
protein coding gene Chr6:42245935-42250447 (.)
129S1/SvImJ MGP_129S1SvImJ_G0030643
protein coding gene Chr6:40748196-40752708 (+)
A/J MGP_AJ_G0030616
protein coding gene Chr6:38971308-38975820 (+)
AKR/J MGP_AKRJ_G0030541
protein coding gene Chr6:40240039-40244551 (+)
BALB/cJ MGP_BALBcJ_G0030626
protein coding gene Chr6:39217548-39222060 (+)
C3H/HeJ MGP_C3HHeJ_G0030339
protein coding gene Chr6:40269509-40274021 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031080
protein coding gene Chr6:41773995-41778507 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028287
protein coding gene Chr6:36855781-36860649 (+)
CAST/EiJ MGP_CASTEiJ_G0029743
protein coding gene Chr6:40107051-40111672 (+)
CBA/J MGP_CBAJ_G0030315
protein coding gene Chr6:43467602-43472114 (+)
DBA/2J MGP_DBA2J_G0030459
protein coding gene Chr6:38824641-38829153 (+)
FVB/NJ MGP_FVBNJ_G0030415
protein coding gene Chr6:38571564-38576074 (+)
LP/J MGP_LPJ_G0030547
protein coding gene Chr6:40719254-40723770 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030449
protein coding gene Chr6:45755026-45759538 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031110
protein coding gene Chr6:40210712-40215224 (+)
PWK/PhJ MGP_PWKPhJ_G0029455
protein coding gene Chr6:38387350-38392401 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029291
protein coding gene Chr6:39781456-39785853 (-)
WSB/EiJ MGP_WSBEiJ_G0029819
protein coding gene Chr6:40202689-40207314 (+)



Homology
more
  • Human Ortholog
    GSTK1, glutathione S-transferase kappa 1
  • Vertebrate Orthologs
    15
  • Human Ortholog
    GSTK1, glutathione S-transferase kappa 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    GST, GST13, GST 13-13, GST13-13, GSTK1-1, hGSTK1
  • Links
    NCBI Gene ID: 373156
    neXtProt AC: NX_Q9Y2Q3
    UniProt: Q9Y2Q3

  • Chr Location
    7q34; chr7:143263429-143269129 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal male survival curves associated with increased glomerular nephropathy.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 76263 NCBI Gene Model | MGI Sequence Detail 4507 C57BL/6J ±  kb
    transcript NM_029555 RefSeq | MGI Sequence Detail 930 C57BL/6  
    polypeptide Q9DCM2 UniProt | EBI | MGI Sequence Detail 226 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 54
      cDNA 53
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2139339
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 1
      Gene Ontology 11
      Phenotypes 4
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:254198 Bai J, et al., DsbA-L prevents obesity-induced inflammation and insulin resistance by suppressing the mtDNA release-activated cGAS-cGAMP-STING pathway. Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):12196-12201

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory