Ercc6l2 MGI Mouse Gene Detail - MGI:1923501 - excision repair cross-complementing rodent repair deficiency, complementation group 6 like 2

Symbol

Ercc6l2
Name

excision repair cross-complementing rodent repair deficiency, complementation group 6 like 2
Synonyms

0610007P08Rik, 1700019D06Rik, 9330134C04Rik

Feature Type

protein coding gene
IDs

MGI:1923501
NCBI Gene: 76251
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr13:63815240-63900302 bp, + strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 33.10 cM, cytoband B3
Mapping Data

3 experiments

SNPs within 2kb

566 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1923501	protein coding gene	Chr13:63810979-63900302 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020671	protein coding gene	Chr13:63801433-63901321 (+)
A/J	MGP_AJ_G0020625	protein coding gene	Chr13:61486018-61572310 (+)
AKR/J	MGP_AKRJ_G0020602	protein coding gene	Chr13:63532766-63625454 (+)
BALB/cJ	MGP_BALBcJ_G0020623	protein coding gene	Chr13:61918485-62001893 (+)
C3H/HeJ	MGP_C3HHeJ_G0020418	protein coding gene	Chr13:63066729-63152719 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021059	protein coding gene	Chr13:65869725-65958477 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018635	protein coding gene	Chr13:59142184-59238242 (+)
CAST/EiJ	MGP_CASTEiJ_G0019935	protein coding gene	Chr13:63074000-63162107 (+)
CBA/J	MGP_CBAJ_G0020378	protein coding gene	Chr13:68409574-68506310 (+)
DBA/2J	MGP_DBA2J_G0020503	protein coding gene	Chr13:61324599-61416314 (+)
FVB/NJ	MGP_FVBNJ_G0020482	protein coding gene	Chr13:60435420-60520202 (+)
LP/J	MGP_LPJ_G0020577	protein coding gene	Chr13:64086708-64176813 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020511	protein coding gene	Chr13:67368615-67467783 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021101	protein coding gene	Chr13:62847632-62937462 (+)
PWK/PhJ	MGP_PWKPhJ_G0019689	protein coding gene	Chr13:60880611-60966916 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019515	protein coding gene	Chr13:61001054-61093182 (+)
WSB/EiJ	MGP_WSBEiJ_G0019995	protein coding gene	Chr13:63328855-63421388 (+)

Human Ortholog

ERCC6L2, ERCC excision repair 6 like 2

Vertebrate Orthologs

7

Human Ortholog

ERCC6L2, ERCC excision repair 6 like 2
Orthology source: HomoloGene, HGNC
Synonyms

BMFS2, C9orf102, HEBO, RAD26L, SR278
Links

HGNC:26922

NCBI Gene ID: 375748

neXtProt AC: NX_Q5T890

UniProt: Q5T890
Chr Location

9q22.32; chr9:95875618-96041092 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 32564
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 chicken;1 zebrafish
HCOP

human homology predictions: ERCC6L2
Gene Tree

Ercc6l2

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Phenotype Summary

9 phenotype references

All Mutations and Alleles

5
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

1
Targeted

2
Genomic Mutations

1 involving Ercc6l2
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

0 strains or lines available

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All GO Annotations

17
GO References

3

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

631
cDNA Data

81

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ercc6l2

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Ercc6l2 interacts with 292 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

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All Sequences

83
RefSeq

14
UniProt

8
CCDS

CCDS26593.2, CCDS36701.1
UniGene

186610

Ensembl

ENSMUSG00000021470 (Evidence)
NCBI Gene

76251

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021470	Ensembl Gene Model \| MGI Sequence Detail	85063	C57BL/6J	± kb
transcript	ENSMUST00000238465	Ensembl \| MGI Sequence Detail	4614	Not Applicable
polypeptide	ENSMUSP00000158755	Ensembl \| MGI Sequence Detail	1537	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000031586 DNA excision repair protein ERCC-6-like 2

(term hierarchy)
EC

3.6.4.-
InterPro Domains

IPR002464 DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site

IPR029256 Helicase-associated putative binding domain

IPR001650 Helicase, C-terminal

IPR014001 Helicase superfamily 1/2, ATP-binding domain

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR038718 SNF2-like, N-terminal domain superfamily

IPR000330 SNF2-related, N-terminal domain

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All nucleic 81

cDNA 81

Microarray probesets 8

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MGI:1916653, MGI:3689365

Summaries

All 32

Gene Ontology 3

Phenotypes 9
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

TSS for Ercc6l2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr120195	Chr13:63815290-63815379 (+)	95 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 07/07/2020 MGI 6.15