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Krt75 Gene Detail
Summary
  • Symbol
    Krt75
  • Name
    keratin 75
  • Synonyms
    4732468K03Rik, K6hf, Krt2-6hf, Krtcap1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923500
    NCBI Gene: 109052
Location & Maps
more
  • Sequence Map
    Chr15:101563345-101573904 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10560 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 56.91 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    KRT75, keratin 75
  • Vertebrate Orthologs
    9
  • Human Ortholog
    KRT75, keratin 75
    Orthology source: HomoloGene
  • Synonyms
    K6HF, KB18, PFB
  • Links
    NCBI Gene ID: 9119
    neXtProt AC: NX_O95678

  • Chr Location
    12q13; chr12:52424070-52434326 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human KRT75 associations

Human Disease Mouse Models
       Pseudofolliculitis Barbae   OMIM: 612318
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Radiation induced
    2
  • Targeted
    2
  • Genomic Mutations
    4 involving Krt75
  • Incidental Mutations
Mice homozygous for a knock-in mutation that results in the deletion of the highly conserved asparagine residue (N159) in the helix initiation peptide of this gene develop hair shaft and nail abnormalities resembling pachyonychia congenita.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028197 VEGA Gene Model | MGI Sequence Detail 10560 C57BL/6J ±  kb
transcript OTTMUST00000069850 VEGA | MGI Sequence Detail 3266 Not Applicable  
polypeptide OTTMUSP00000035534 VEGA | MGI Sequence Detail 551 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    110 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 20
    Genomic 5
    cDNA 15

    Microarray probesets 2
Other
Accession IDs
less
MGI:2145919
References
more
  • Summaries
    All 32
    Developmental Gene Expression 8
    Diseases 1
    Gene Ontology 4
    Phenotypes 24
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:231070 Liu Y, et al., Gorab Is Required for Dermal Condensate Cells to Respond to Hedgehog Signals during Hair Follicle Morphogenesis. J Invest Dermatol. 2016 Feb;136(2):378-86

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory