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Krt75
Gene Detail
Symbol

Name
ID
Krt75
keratin 75
MGI:1923500
Synonyms
4732468K03Rik, K6hf, Krt2-6hf, Krtcap1
Feature Type
protein coding gene
Genetic Map
Chromosome 15
56.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:101563345-101573904 bp, - strand
From VEGA annotation of GRCm38

  10560 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20983  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 chicken

HCOP human homology predictions: KRT75
Gene Tree: Krt75

Human
homologs
KRT75, keratin 75, type II
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 9119
neXtProt AC: NX_O95678

Human Synonyms: K6HF, KB18, PFB

Human Chr (Location): 12q13; chr12:52424070-52434326 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human KRT75

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Radiation induced(1) Targeted(2)
Genomic Mutations involving Krt75 (2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-in mutation that results in the deletion of the highly conserved asparagine residue (N159) in the helix initiation peptide of this gene develop hair shaft and nail abnormalities resembling pachyonychia congenita.
 
Phenotype Images(2)
Interactions
Krt75 interacts with 232 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process hematopoietic progenitor cell differentiation
Component extracellular exosome, intermediate filament, ...
Function structural molecule activity
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (18)    Tissues (6)    Images (11)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 18
cDNA source data(15)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA KRT6A, KRT75 ; Xenbase LOC100491159    NEW 
Molecular
reagents
All nucleic(20) Genomic(5) cDNA(15)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000028197 (Evidence)
Ensembl Gene Model ENSMUSG00000022986 (Evidence)
Entrez Gene 109052 (Evidence)
UniGene 106868
DFCI TC1586504
DoTS DT.529869
Consensus CDS Project CCDS27856.1
International Mouse Phenotyping Consortium Status Krt75
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028197 VEGA Gene Model | MGI Sequence Detail 10560 C57BL/6J ±  kb
transcript OTTMUST00000069850 VEGA | MGI Sequence Detail 3266 Not Applicable 
polypeptide OTTMUSP00000035534 VEGA | MGI Sequence Detail 551 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(110 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001664 Intermediate filament protein
InterPro IPR018039 Intermediate filament protein, conserved site
InterPro IPR003054 Keratin, type II
InterPro IPR009053 Prefoldin
Protein Ontology PR:000009490 keratin, type II cytoskeletal 75
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:219416 Duverger O, et al., Hair keratin mutations in tooth enamel increase dental decay risk. J Clin Invest. 2014 Dec;124(12):5219-24
All references(31)
Other
accession IDs
MGI:2145919

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory