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Krt75
Gene Detail
 Symbol
Name
ID
Krt75
keratin 75
MGI:1923500
Synonyms 4732468K03Rik, K6hf, Krt2-6hf, Krtcap1
Feature Type protein coding gene
Genetic Map
Chromosome 15
56.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:101563345-101573904 bp, - strand
From VEGA annotation of GRCm38

  10560 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20983  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 chicken

Gene Tree: Krt75

Human
homologs
Human Homolog KRT75, keratin 75
NCBI Gene ID 9119
neXtProt AC  NX_O95678
Human Synonyms  K6HF, KB18, PFB
Human Chr (Location)  12q13; chr12:52424070-52434326 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human KRT75
Alleles
and
phenotypes
All alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-in mutation that results in the deletion of the highly conserved asparagine residue (N159) in the helix initiation peptide of this gene develop hair shaft and nail abnormalities resembling pachyonychia congenita.
 
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process hematopoietic progenitor cell differentiation
Component extracellular vesicular exosome, intermediate filament, ...
Function structural molecule activity
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (18)    Tissues (6)    Images (11)
Theiler Stages: 23
Assay TypeResults
RNA in situ 18
cDNA source data(15)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(20) Genomic(5) cDNA(15)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000028197 (Evidence)
Ensembl Gene ModelENSMUSG00000022986 (Evidence)
Entrez Gene109052 (Evidence)
UniGene106868
DFCITC1586504
DoTSDT.529869
Consensus CDS ProjectCCDS27856.1
International Mouse Knockout Project StatusKrt75
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028197 VEGA Gene Model | MGI Sequence Detail 10560 C57BL/6J ±  kb
transcript OTTMUST00000069850 VEGA | MGI Sequence Detail 3266 Not Applicable 
polypeptide OTTMUSP00000035534 VEGA | MGI Sequence Detail 551 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(110 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001664 Intermediate filament protein
InterPro IPR018039 Intermediate filament protein, conserved site
InterPro IPR009053 Prefoldin
InterPro IPR003054 Type II keratin
Protein Ontology PR:000009490 keratin, type II cytoskeletal 75
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:206321 Veniaminova NA, et al., Keratin 79 identifies a novel population of migratory epithelial cells that initiates hair canal morphogenesis and regeneration. Development. 2013 Dec;140(24):4870-80
All references(31)
Other
accession IDs
MGI:2145919

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory