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Rph3al
Gene Detail
 Symbol
Name
ID
Rph3al
rabphilin 3A-like (without C2 domains)
MGI:1923492
Synonyms 6530413F01Rik, LOC385671, Noc2
Feature Type protein coding gene
Genetic Map
Chromosome 11
45.92 cM, cytoband B4
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr11:75830999-75938429 bp, - strand
From VEGA annotation of GRCm38

  107431 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5078  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: Rab effector protein Noc2
Gene Tree: Rph3al

Human
homologs
Human Homolog RPH3AL, rabphilin 3A-like (without C2 domains)
NCBI Gene ID 9501
neXtProt AC  NX_Q9UNE2
Human Synonyms  NOC2
Human Chr (Location)  17p13.3; chr17:212389-386254 (-)  GRCh38
Alleles
and
phenotypes
All alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit disregulation of exocytosis in both endocrine and exocrine cells.
 
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process exocytosis, glucose homeostasis, ...
Component cytoplasm, cytoplasmic vesicle, ...
Function LIM domain binding, metal ion binding, ...
External Resources: FuncBase
Expression
cDNA source data(6)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(6) cDNA(6)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000006223 (Evidence)
Ensembl Gene ModelENSMUSG00000020847 (Evidence)
Entrez Gene380714 (Evidence)
DFCITC1588839, TC1589800, TC1669984
DoTSDT.40140677, DT.55279592, DT.91429298
NIA Mouse Gene IndexU033092, U277858
Consensus CDS ProjectCCDS25058.1, CCDS70243.1
International Mouse Knockout Project StatusRph3al
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006223 VEGA Gene Model | MGI Sequence Detail 107431 C57BL/6J ±  kb
transcript OTTMUST00000014049 VEGA | MGI Sequence Detail 2199 Not Applicable 
polypeptide OTTMUSP00000006525 VEGA | MGI Sequence Detail 302 Not Applicable 

For the selected sequences
All sequences(65) RefSeq(19) UniProt(2)
Polymorphisms SNPs within 2kb(595 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR010911 Rab-binding domain
InterPro IPR011011 Zinc finger, FYVE/PHD-type
InterPro IPR017455 Zinc finger, FYVE-related
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
Protein Ontology PR:000014185 rab effector Noc2
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:187232 Ogata S, et al., A novel function of Noc2 in agonist-induced intracellular Ca2+ increase during zymogen-granule exocytosis in pancreatic acinar cells. PLoS One. 2012;7(5):e37048
All references(35)
Other
accession IDs
MGI:2144220, MGI:2686599

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory