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Rph3al Gene Detail
Summary
  • Symbol
    Rph3al
  • Name
    rabphilin 3A-like (without C2 domains)
  • Synonyms
    6530413F01Rik, LOC385671, Noc2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923492
    NCBI Gene: 380714
Location & Maps
more
  • Sequence Map
    Chr11:75830999-75938429 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      107431 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    RPH3AL, rabphilin 3A-like (without C2 domains)
  • Vertebrate Orthologs
    8
  • Human Ortholog
    RPH3AL, rabphilin 3A-like (without C2 domains)
    Orthology source: HGNC, HomoloGene
  • Synonyms
    NOC2
  • Links
    NCBI Gene ID: 9501
    neXtProt AC: NX_Q9UNE2

  • Chr Location
    17p13.3; chr17:212389-386254 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Targeted
    6
  • Genomic Mutations
    2 involving Rph3al
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit disregulation of exocytosis in both endocrine and exocrine cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006223 VEGA Gene Model | MGI Sequence Detail 107431 C57BL/6J ±  kb
transcript OTTMUST00000014049 VEGA | MGI Sequence Detail 2199 Not Applicable  
polypeptide OTTMUSP00000006525 VEGA | MGI Sequence Detail 302 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    595 from dbSNP Build 137
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 6
    cDNA 6

    Microarray probesets 3
Other
Accession IDs
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MGI:2144220, MGI:2686599
References
more
  • Summaries
    All 31
    Gene Ontology 6
    Phenotypes 13
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:187232 Ogata S, et al., A novel function of Noc2 in agonist-induced intracellular Ca2+ increase during zymogen-granule exocytosis in pancreatic acinar cells. PLoS One. 2012;7(5):e37048

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory