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Magi3 Gene Detail
Summary
  • Symbol
    Magi3
  • Name
    membrane associated guanylate kinase, WW and PDZ domain containing 3
  • Synonyms
    4732496O19Rik, 6530407C02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923484
    NCBI Gene: 99470
  • Gene Overview
    MyGene.info: MAGI3
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:104013259-104220374 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 45.52 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    407 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923484
protein coding gene Chr3:104013259-104220406 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027705
protein coding gene Chr3:105318588-105514777 (-)
A/J MGP_AJ_G0027665
protein coding gene Chr3:101962409-102159192 (-)
AKR/J MGP_AKRJ_G0027630
protein coding gene Chr3:104448991-104658418 (-)
BALB/cJ MGP_BALBcJ_G0027677
protein coding gene Chr3:101732073-101934847 (-)
C3H/HeJ MGP_C3HHeJ_G0027407
protein coding gene Chr3:104823984-105034482 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028121
protein coding gene Chr3:109215949-109439940 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025461
protein coding gene Chr3:98098721-98289329 (-)
CAST/EiJ MGP_CASTEiJ_G0026863
protein coding gene Chr3:103935761-104150440 (-)
CBA/J MGP_CBAJ_G0027382
protein coding gene Chr3:112946656-113179816 (-)
DBA/2J MGP_DBA2J_G0027524
protein coding gene Chr3:101206191-101412578 (-)
FVB/NJ MGP_FVBNJ_G0027492
protein coding gene Chr3:99131922-99339185 (-)
LP/J MGP_LPJ_G0027631
protein coding gene Chr3:106654089-106869112 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027522
protein coding gene Chr3:119069188-119325194 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028176
protein coding gene Chr3:104008265-104225087 (-)
PWK/PhJ MGP_PWKPhJ_G0026589
protein coding gene Chr3:100983377-101191895 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026410
protein coding gene Chr3:102072151-102267062 (-)
WSB/EiJ MGP_WSBEiJ_G0026943
protein coding gene Chr3:104565105-104785580 (-)



Homology
more
  • Human Ortholog
    MAGI3, membrane associated guanylate kinase, WW and PDZ domain containing 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MAGI3, membrane associated guanylate kinase, WW and PDZ domain containing 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    dJ730K3.2, MAGI-3
  • Links
    NCBI Gene ID: 260425
    neXtProt AC: NX_Q5TCQ9
    UniProt: Q5TCQ9

  • Chr Location
    1p13.2; chr1:113390474-113685923 (+)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000052539 Ensembl Gene Model | MGI Sequence Detail 207116 C57BL/6J ±  kb
transcript ENSMUST00000121198 Ensembl | MGI Sequence Detail 5912 Not Applicable  
polypeptide ENSMUSP00000112934 Ensembl | MGI Sequence Detail 1476 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • InterPro Domains
    IPR020590 Guanylate kinase, conserved site
    IPR008144 Guanylate kinase-like domain
    IPR008145 Guanylate kinase/L-type calcium channel beta subunit
    IPR030035 Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3
    IPR001478 PDZ domain
    IPR036034 PDZ superfamily
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR001202 WW domain
    IPR036020 WW domain superfamily
Molecular
Reagents
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  • All nucleic 58
    cDNA 57
    Primer pair 1

    Microarray probesets 7
Other
Accession IDs
less
MGI:2139551, MGI:2139629
References
more
  • Summaries
    All 35
    Developmental Gene Expression 4
    Diseases 1
    Gene Ontology 8
    Phenotypes 6
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:245710 Adam MG, et al., Synaptojanin-2 binding protein stabilizes the Notch ligands DLL1 and DLL4 and inhibits sprouting angiogenesis. Circ Res. 2013 Nov 08;113(11):1206-18

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory