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Lamp5 Gene Detail
Summary
  • Symbol
    Lamp5
  • Name
    lysosomal-associated membrane protein family, member 5
  • Synonyms
    3110035N03Rik, 6330527O06Rik, BAD-LAMP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923411
    NCBI Gene: 76161
  • Alliance
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:136052239-136069917 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 67.26 cM, cytoband G1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    114 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923411
protein coding gene Chr2:136052023-136069917 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026556
protein coding gene Chr2:139812925-139830504 (+)
A/J MGP_AJ_G0026520
protein coding gene Chr2:134129001-134146745 (+)
AKR/J MGP_AKRJ_G0026494
protein coding gene Chr2:137982236-137999845 (+)
BALB/cJ MGP_BALBcJ_G0026532
protein coding gene Chr2:134518070-134536457 (+)
C3H/HeJ MGP_C3HHeJ_G0026275
protein coding gene Chr2:138436974-138456969 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026977
protein coding gene Chr2:144020089-144037697 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024354
protein coding gene Chr2:128692067-128709819 (+)
CAST/EiJ MGP_CASTEiJ_G0025736
protein coding gene Chr2:138782780-138801749 (+)
CBA/J MGP_CBAJ_G0026255
protein coding gene Chr2:149389932-149407550 (+)
DBA/2J MGP_DBA2J_G0026389
protein coding gene Chr2:133507463-133525741 (+)
FVB/NJ MGP_FVBNJ_G0026353
protein coding gene Chr2:132096808-132115227 (+)
LP/J MGP_LPJ_G0026493
protein coding gene Chr2:139983072-140000655 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026373
protein coding gene Chr2:153192017-153211615 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027032
protein coding gene Chr2:137996251-138014272 (+)
PWK/PhJ MGP_PWKPhJ_G0025472
protein coding gene Chr2:133107555-133125317 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025274
protein coding gene Chr2:137097897-137116678 (+)
WSB/EiJ MGP_WSBEiJ_G0025810
protein coding gene Chr2:138917478-138935724 (+)



Homology
more
  • Human Ortholog
    LAMP5, lysosomal associated membrane protein family member 5
  • Vertebrate Orthologs
    9
  • Human Ortholog
    LAMP5, lysosomal associated membrane protein family member 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BADLAMP, BAD-LAMP, C20orf103, LAMP-5, UNC-46
  • Links
    NCBI Gene ID: 24141
    neXtProt AC: NX_Q9UJQ1
    UniProt: Q9UJQ1

  • Chr Location
    20p12.2; chr20:9514358-9530524 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 8173
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: LAMP5
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotype references
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Radiation induced
    2
  • Targeted
    2
  • Genomic Mutations
    3 involving Lamp5
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000027270 Ensembl Gene Model | MGI Sequence Detail 17679 C57BL/6J ±  kb
transcript ENSMUST00000057503 Ensembl | MGI Sequence Detail 1955 Not Applicable  
polypeptide ENSMUSP00000061180 Ensembl | MGI Sequence Detail 280 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000032148 lysosome-associated membrane glycoprotein 5
  • InterPro Domains
    IPR002000 Lysosome-associated membrane glycoprotein
    IPR018134 Lysosome-associated membrane glycoprotein, conserved site
Molecular
Reagents
less
  • All nucleic 8
    cDNA 8

    Microarray probesets 3
Other
Accession IDs
less
MGI:1920368
References
more
  • Summaries
    All 55
    Developmental Gene Expression 5
    Diseases 1
    Gene Ontology 6
    Phenotypes 26
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:249162 Tiveron MC, et al., LAMP5 Fine-Tunes GABAergic Synaptic Transmission in Defined Circuits of the Mouse Brain. PLoS One. 2016;11(6):e0157052

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory