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Slc35d3 Gene Detail
Summary
  • Symbol
    Slc35d3
  • Name
    solute carrier family 35, member D3
  • Synonyms
    6230421J19Rik, Frcl1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923407
    NCBI Gene: 76157
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:19847916-19851459 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 9.12 cM, cytoband A2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    31 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923407
protein coding gene Chr10:19847916-19852363 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017049
protein coding gene Chr10:17574489-17578031 (-)
A/J MGP_AJ_G0017027
protein coding gene Chr10:16904276-16907818 (-)
AKR/J MGP_AKRJ_G0016991
protein coding gene Chr10:17177260-17180802 (-)
BALB/cJ MGP_BALBcJ_G0016985
protein coding gene Chr10:16955854-16959396 (-)
C3H/HeJ MGP_C3HHeJ_G0016810
protein coding gene Chr10:17509875-17513417 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017447
protein coding gene Chr10:18002112-18005654 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015152
protein coding gene Chr10:15906256-15909812 (-)
CAST/EiJ MGP_CASTEiJ_G0016392
protein coding gene Chr10:17389997-17393540 (-)
CBA/J MGP_CBAJ_G0016782
protein coding gene Chr10:18826032-18829574 (-)
DBA/2J MGP_DBA2J_G0016890
protein coding gene Chr10:16784071-16787613 (-)
FVB/NJ MGP_FVBNJ_G0016885
protein coding gene Chr10:16542184-16545726 (-)
LP/J MGP_LPJ_G0016965
protein coding gene Chr10:17374494-17378036 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016915
protein coding gene Chr10:19080003-19083545 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017485
protein coding gene Chr10:17186569-17190111 (-)
PWK/PhJ MGP_PWKPhJ_G0016177
protein coding gene Chr10:16626864-16659501 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015960
protein coding gene Chr10:17324739-17340064 (-)
WSB/EiJ MGP_WSBEiJ_G0016454
protein coding gene Chr10:17271742-17275282 (-)



Homology
more
  • Human Ortholog
    SLC35D3, solute carrier family 35 member D3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SLC35D3, solute carrier family 35 member D3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FRCL1
  • Links
    NCBI Gene ID: 340146
    neXtProt AC: NX_Q5M8T2
    UniProt: Q5M8T2

  • Chr Location
    6q23.3; chr6:136922241-136925660 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a spontaneous mutation exhibit decreased platelet serotonin.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000050473 Ensembl Gene Model | MGI Sequence Detail 3544 C57BL/6J ±  kb
transcript ENSMUST00000059805 Ensembl | MGI Sequence Detail 2630 Not Applicable  
polypeptide ENSMUSP00000060589 Ensembl | MGI Sequence Detail 422 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    cDNA 11
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 34
    Developmental Gene Expression 2
    Gene Ontology 3
    Phenotypes 10
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:211009 Zhang Z, et al., Mutation of SLC35D3 causes metabolic syndrome by impairing dopamine signaling in striatal D1 neurons. PLoS Genet. 2014 Feb;10(2):e1004124

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
06/18/2019
MGI 6.14
The Jackson Laboratory