About   Help   FAQ
Gpsm2 Gene Detail
Summary
  • Symbol
    Gpsm2
  • Name
    G-protein signalling modulator 2 (AGS3-like, C. elegans)
  • Synonyms
    6230410J09Rik, LGN, Pins
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923373
    NCBI Gene: 76123
  • Alliance
    genome feature page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:108585954-108629625 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 47.53 cM, cytoband F3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1260 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923373
 protein coding gene Chr3:108585954-108629637 (-)
129S1/SvImJ ENSMUSG00200035422
 protein coding gene Chr3:105202627-105246298 (-)
A/J ENSMUSG00195023723
 protein coding gene Chr3:105629098-105672779 (-)
AKR/J ENSMUSG00220026762
 protein coding gene Chr3:103992858-104036522 (-)
BALB/cJ ENSMUSG00180015549
 protein coding gene Chr3:105575883-105619593 (-)
C3H/HeJ ENSMUSG00175025828
 protein coding gene Chr3:105109034-105152706 (-)
C57BL/6NJ ENSMUSG00215027057
 protein coding gene Chr3:105837091-105880772 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025538
 protein coding gene Chr3:102880246-102921728 (-)
CAST/EiJ ENSTCUG00005024906
 protein coding gene Chr3:106108502-106149628 (-)
CBA/J ENSMUSG00210007481
 protein coding gene Chr3:105730953-105774622 (-)
DBA/2J ENSMUSG00185021523
 protein coding gene Chr3:106200422-106244086 (-)
FVB/NJ ENSMUSG00205023531
 protein coding gene Chr3:104767065-104810737 (-)
JF1/MsJ ENSUMUG00000001874
 protein coding gene Chr3:105179044-105219956 (-)
LP/J ENSMUSG00230018450
 protein coding gene Chr3:108115619-108159285 (-)
NOD/ShiLtJ ENSMUSG00190036327
 protein coding gene Chr3:106438460-106482130 (-)
NZO/HlLtJ ENSMUSG00225019074
 protein coding gene Chr3:110622278-110665604 (-)
PWK/PhJ ENSLUMG00010024266
 protein coding gene Chr3:105033833-105074678 (-)
SPRET/EiJ ENSMSPG00010034435
 protein coding gene Chr3:105547357-105581283 (-)
WSB/EiJ ENSIUOG00005004011
 protein coding gene Chr3:105752839-105796541 (-)



Homology
more
  • Human Ortholog
    GPSM2, G protein signaling modulator 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GPSM2, G protein signaling modulator 2
  • Synonyms
    CMCS, DFNB82, LGN, PINS
  • Links
    NCBI Gene ID: 29899
    UniProt: P81274

  • Chr Location
    1p13.3; chr1:108875350-108934545 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human GPSM2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 3 alleles in 3 genetic backgrounds
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Targeted disruption of this gene randomizes the spindle orientation of normally planar neuroepithelial divisions. The ensuing loss of the apical membrane from daughter cells frequently converts them into abnormally localized progenitors with no apparent effect on neuronal production.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    71
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    844
  • Tissues
    107
  • cDNA Data
    9
  • Literature Summary
    36
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027883 Ensembl Gene Model | MGI Sequence Detail 43672 C57BL/6J ±  kb
    transcript ENSMUST00000029482 Ensembl | MGI Sequence Detail 3498 Not Applicable  
    polypeptide ENSMUSP00000029482 Ensembl | MGI Sequence Detail 679 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 9
      Primer pair 2
      Other 2
      Antibodies 11

      Microarray probesets 4
    References
    more
    • Summaries
      All 107
      Developmental Gene Expression 36
      Diseases 1
      Gene Ontology 15
      Phenotypes 36
    • Earliest
      J:54235 Luo Y, et al., Interaction of heterotrimeric G protein Galphao with Purkinje cell protein-2. Evidence for a novel nucleotide exchange factor. J Biol Chem. 1999 Apr 16;274(16):10685-8
    • Latest
      J:378933 Boulan B, et al., Oriented cell divisions induce basal progenitors and regulate neural expansion across tissues and species. Sci Adv. 2026 Feb 6;12(6):eadz6827
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory