About   Help   FAQ
Gpsm2
Gene Detail
 Symbol
Name
ID
Gpsm2
G-protein signalling modulator 2 (AGS3-like, C. elegans)
MGI:1923373
Synonyms 6230410J09Rik, LGN, Pins
Feature Type protein coding gene
Genetic Map
Chromosome 3
47.53 cM, cytoband F3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:108678638-108722309 bp, - strand
From VEGA annotation of GRCm38

  43672 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56584  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Gpsm2

Human
homologs
Human Homolog GPSM2, G-protein signaling modulator 2
NCBI Gene ID 29899
neXtProt AC  NX_P81274
Human Synonyms  CMCS, DFNB82, LGN, PINS
Human Chr (Location)  1p13.3; chr1:108876218-108930422 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human GPSM2
Alleles
and
phenotypes
All alleles(11) : Gene trapped(7) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Targeted disruption of this gene randomizes the spindle orientation of normally planar neuroepithelial divisions. The ensuing loss of the apical membrane from daughter cells frequently converts them into abnormally localized progenitors with no apparent effect on neuronal production.
 
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process establishment of mitotic spindle orientation, lung epithelial cell differentiation
Component apical part of cell, cell, ...
Function GTPase regulator activity, identical protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (19)    Tissues (10)   
Theiler Stages: 24, 28
Assay TypeResults
Immunohistochemistry 14
RT-PCR 5
cDNA source data(7)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(8) cDNA(7) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000007258 (Evidence)
Ensembl Gene ModelENSMUSG00000027883 (Evidence)
Entrez Gene76123 (Evidence)
NIA Mouse Gene IndexU024531
PDB4G2V, 4G5O, 4G5Q, 4G5R, 4G5S, 4JHR, 3RO2, 3RO3
Consensus CDS ProjectCCDS51048.1
International Mouse Knockout Project StatusGpsm2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007258 VEGA Gene Model | MGI Sequence Detail 43672 C57BL/6J ±  kb
transcript OTTMUST00000016754 VEGA | MGI Sequence Detail 3498 Not Applicable 
polypeptide OTTMUSP00000007715 VEGA | MGI Sequence Detail 679 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(4) UniProt(3)
Polymorphisms SNPs within 2kb(247 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003109 GoLoco motif
InterPro IPR024804 G-protein-signaling modulator 1
InterPro IPR011990 Tetratricopeptide-like helical
InterPro IPR019734 Tetratricopeptide repeat
InterPro IPR013026 Tetratricopeptide repeat-containing domain
InterPro IPR001440 Tetratricopeptide TPR-1
Protein Ontology PR:000008205 G-protein-signaling modulator 2
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:201606 Ezan J, et al., Primary cilium migration depends on G-protein signalling control of subapical cytoskeleton. Nat Cell Biol. 2013 Sep;15(9):1107-15
All references(41)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/15/2014
MGI 5.18
The Jackson Laboratory