Gpsm2
Gene Detail

Symbol Name ID

Gpsm2 G-protein signalling modulator 2 (AGS3-like, C. elegans) MGI:1923373

Synonyms

6230410J09Rik, LGN, Pins

Feature Type

protein coding gene

Genetic Map

Chromosome 3

47.53 cM, cytoband F3
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr3:108678638-108722187 bp, - strand From VEGA annotation of GRCm38   43550 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:56584  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Gpsm2

Human homologs

Human Homolog		GPSM2, G-protein signaling modulator 2
NCBI Gene ID		29899
neXtProt AC		NX_P81274
Human Synonyms		CMCS, DFNB82, LGN, PINS
Human Chr (Location)		1p13.3; chr1:109419603-109473044 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human GPSM2

Alleles and phenotypes

All alleles(10) : Targeted(3) Gene trapped(7)
 

Targeted disruption of this gene randomizes the spindle orientation of normally planar neuroepithelial divisions. The ensuing loss of the apical membrane from daughter cells frequently converts them into abnormally localized progenitors with no apparent effect on neuronal production.

 

Gene Ontology (GO) classifications

All GO classifications: (9 annotations)

Process	establishment of mitotic spindle orientation, lung epithelial cell differentiation, ...
Component	apical part of cell, cytoplasm, ...
Function	GDP-dissociation inhibitor activity, GTPase regulator activity, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (19)    Tissues (10)   
Theiler Stages: 24, 28

Assay Type	Results
Immunohistochemistry	14
RT-PCR	5

cDNA source data(7)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(8) cDNA(7) Primer pair(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000007258 (Evidence)
Ensembl Gene Model	ENSMUSG00000027883 (Evidence)
Entrez Gene	76123 (Evidence)
NIA Mouse Gene Index	U024531
PDB	4G5O, 4G5Q, 4G5R, 4G5S, 3RO2, 3RO3
Consensus CDS Project	CCDS51048.1
International Mouse Knockout Project Status	Gpsm2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000007258	VEGA Gene Model | MGI Sequence Detail	43550	C57BL/6J
transcript	OTTMUST00000016754	VEGA | MGI Sequence Detail	3376	Not Applicable
polypeptide	OTTMUSP00000007715	VEGA | MGI Sequence Detail	679	Not Applicable

All sequences(30) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(237 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR023114	Elongated TPR repeat-containing domain
InterPro	IPR003109	GoLoco motif
InterPro	IPR024807	G-protein-signaling modulator 2
InterPro	IPR011990	Tetratricopeptide-like helical
InterPro	IPR019734	Tetratricopeptide repeat
InterPro	IPR013026	Tetratricopeptide repeat-containing domain
InterPro	IPR001440	Tetratricopeptide TPR-1
Protein Ontology	PR:000008205	G-protein-signaling modulator 2

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(36)