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Gpsm2
Gene Detail
Symbol

Name
ID
Gpsm2
G-protein signalling modulator 2 (AGS3-like, C. elegans)
MGI:1923373
Synonyms
6230410J09Rik, LGN, Pins
Feature Type
protein coding gene
Genetic Map
Chromosome 3
47.53 cM, cytoband F3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:108678638-108722309 bp, - strand
From VEGA annotation of GRCm38

  43672 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56584  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GPSM2
Gene Tree: Gpsm2

Human
homologs
GPSM2, G-protein signaling modulator 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 29899
neXtProt AC: NX_P81274

Human Synonyms: CMCS, DFNB82, LGN, PINS

Human Chr (Location): 1p13.3; chr1:108875350-108930422 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human GPSM2

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(7) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Targeted disruption of this gene randomizes the spindle orientation of normally planar neuroepithelial divisions. The ensuing loss of the apical membrane from daughter cells frequently converts them into abnormally localized progenitors with no apparent effect on neuronal production.
 
Interactions
Gpsm2 interacts with 165 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (11 records)
Data Summary: Results (211)    Tissues (94)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 99
RNA in situ 72
Northern blot 12
Western blot 8
RT-PCR 20
cDNA source data(8)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase gpsm2    NEW 
Molecular
reagents
All nucleic(11) cDNA(8) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000007258 (Evidence)
Ensembl Gene Model ENSMUSG00000027883 (Evidence)
Entrez Gene 76123 (Evidence)
NIA Mouse Gene Index U024531
PDB 4G5Q, 4G5O, 4G2V, 4JHR, 4G5R, 4G5S, 3RO3, 3RO2
Consensus CDS Project CCDS51048.1
International Mouse Phenotyping Consortium Status Gpsm2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007258 VEGA Gene Model | MGI Sequence Detail 43672 C57BL/6J ±  kb
transcript OTTMUST00000016754 VEGA | MGI Sequence Detail 3498 Not Applicable 
polypeptide OTTMUSP00000007715 VEGA | MGI Sequence Detail 679 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(247 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003109 GoLoco motif
InterPro IPR024804 G-protein-signaling modulator 1
InterPro IPR011990 Tetratricopeptide-like helical
InterPro IPR019734 Tetratricopeptide repeat
InterPro IPR013026 Tetratricopeptide repeat-containing domain
InterPro IPR001440 Tetratricopeptide TPR-1
Protein Ontology PR:000008205 G-protein-signaling modulator 2
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:219386 Williams SE, et al., Par3-mInsc and Galphai3 cooperate to promote oriented epidermal cell divisions through LGN. Nat Cell Biol. 2014 Aug;16(8):758-69
All references(43)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory