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Jakmip1 Gene Detail
Summary
  • Symbol
    Jakmip1
  • Name
    janus kinase and microtubule interacting protein 1
  • Synonyms
    5830437M04Rik, C330021K24Rik, Gababrbp, Marlin-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923321
    NCBI Gene: 76071
  • Alliance
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:37028335-37150607 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 19.66 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    593 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923321
protein coding gene Chr5:37026951-37150614 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029498
protein coding gene Chr5:35366099-35492181 (+)
A/J MGP_AJ_G0029464
protein coding gene Chr5:34211440-34343820 (+)
AKR/J MGP_AKRJ_G0029414
protein coding gene Chr5:35504107-35633275 (+)
BALB/cJ MGP_BALBcJ_G0029475
protein coding gene Chr5:34709683-34833033 (+)
C3H/HeJ MGP_C3HHeJ_G0029198
protein coding gene Chr5:35501590-35627088 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029929
protein coding gene Chr5:37284282-37413722 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027167
protein coding gene Chr5:31934135-32055605 (+)
CAST/EiJ MGP_CASTEiJ_G0028606
protein coding gene Chr5:34650660-34779357 (+)
CBA/J MGP_CBAJ_G0029165
protein coding gene Chr5:38201878-38342383 (+)
DBA/2J MGP_DBA2J_G0029312
protein coding gene Chr5:34336463-34460311 (+)
FVB/NJ MGP_FVBNJ_G0029271
protein coding gene Chr5:33818731-33940218 (+)
LP/J MGP_LPJ_G0029398
protein coding gene Chr5:35826299-35952912 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029301
protein coding gene Chr5:38930556-39061811 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029962
protein coding gene Chr5:34992983-35118600 (+)
PWK/PhJ MGP_PWKPhJ_G0028330
protein coding gene Chr5:33520474-33643973 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028163
protein coding gene Chr5:34461050-34589773 (+)
WSB/EiJ MGP_WSBEiJ_G0028687
protein coding gene Chr5:35078163-35207722 (+)



Homology
more
  • Human Ortholog
    JAKMIP1, janus kinase and microtubule interacting protein 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    JAKMIP1, janus kinase and microtubule interacting protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Gababrbp, JAMIP1, MARLIN1
  • Links
    NCBI Gene ID: 152789
    neXtProt AC: NX_Q96N16
    UniProt: Q96N16

  • Chr Location
    4p16.1; chr4:6024925-6200591 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Jakmip1 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in social deficits, stereotyped activity, abnormal postnatal vocalizations, reduced anxiety/increased impulsivity and glutamatergic NMDAR signaling deficits.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000063646 Ensembl Gene Model | MGI Sequence Detail 122273 C57BL/6J ±  kb
    transcript ENSMUST00000121010 Ensembl | MGI Sequence Detail 2496 Not Applicable  
    polypeptide ENSMUSP00000113624 Ensembl | MGI Sequence Detail 831 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • Protein Ontology
      PR:000009199 Janus kinase and microtubule-interacting protein 1
    • InterPro Domains
      IPR024836 Janus kinase and microtubule-interacting protein
      IPR031994 Janus kinase and microtubule-interacting protein, C-terminal domain
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 18

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1925951
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 2
      Diseases 2
      Gene Ontology 7
      Phenotypes 23
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:228732 Berg JM, et al., JAKMIP1, a Novel Regulator of Neuronal Translation, Modulates Synaptic Function and Autistic-like Behaviors in Mouse. Neuron. 2015 Dec 16;88(6):1173-91

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    last database update
    10/08/2019
    MGI 6.14
    The Jackson Laboratory