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Slain2 Gene Detail
Summary
  • Symbol
    Slain2
  • Name
    SLAIN motif family, member 2
  • Synonyms
    5033405K12Rik, 8030444K12Rik, mKIAA1458
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923241
    NCBI Gene: 75991
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:72914362-72978841 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 38.44 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    212 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923241
protein coding gene Chr5:72914304-72978841 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029618
protein coding gene Chr5:72878013-72946434 (+)
A/J MGP_AJ_G0029586
protein coding gene Chr5:70154223-70216172 (+)
AKR/J MGP_AKRJ_G0029534
protein coding gene Chr5:72398365-72468358 (+)
BALB/cJ MGP_BALBcJ_G0029594
protein coding gene Chr5:70860786-70931601 (+)
C3H/HeJ MGP_C3HHeJ_G0029319
protein coding gene Chr5:72786752-72851578 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030049
protein coding gene Chr5:75865331-75933893 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027291
protein coding gene Chr5:65858763-65921615 (+)
CAST/EiJ MGP_CASTEiJ_G0028728
protein coding gene Chr5:71883489-71954214 (+)
CBA/J MGP_CBAJ_G0029287
protein coding gene Chr5:78323797-78398298 (+)
DBA/2J MGP_DBA2J_G0029434
protein coding gene Chr5:70206114-70271916 (+)
FVB/NJ MGP_FVBNJ_G0029394
protein coding gene Chr5:69369209-69439247 (+)
LP/J MGP_LPJ_G0029518
protein coding gene Chr5:73326452-73392233 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029420
protein coding gene Chr5:81649561-81720608 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030083
protein coding gene Chr5:71974320-72039696 (+)
PWK/PhJ MGP_PWKPhJ_G0028450
protein coding gene Chr5:69185893-69250841 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028283
protein coding gene Chr5:71300817-71367876 (+)
WSB/EiJ MGP_WSBEiJ_G0028808
protein coding gene Chr5:72264865-72329431 (+)



Homology
more
  • Human Ortholog
    SLAIN2, SLAIN motif family member 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SLAIN2, SLAIN motif family member 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    KIAA1458
  • Links
    NCBI Gene ID: 57606
    neXtProt AC: NX_Q9P270
    UniProt: Q9P270

  • Chr Location
    4p11; chr4:48341480-48426198 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 18952
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SLAIN2
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    282 phenotype references
  • All Mutations and Alleles
    24
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    1
  • Gene trapped
    16
  • Radiation induced
    1
  • Spontaneous
    3
  • Targeted
    1
  • Genomic Mutations
    6 involving Slain2
  • Incidental Mutations
    APF , CvDC
  • Find Mice (IMSR)
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 75991 NCBI Gene Model | MGI Sequence Detail 64480 C57BL/6J ±  kb
transcript NM_153567 RefSeq | MGI Sequence Detail 4865 C57BL/6  
polypeptide Q8CI08 UniProt | EBI | MGI Sequence Detail 581 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 91
    cDNA 91

    Microarray probesets 7
Other
Accession IDs
less
MGI:2140939, MGI:2444168
References
more
  • Summaries
    All 310
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 3
    Phenotypes 282
  • Earliest
    J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
  • Latest
    J:275367 Sanchez E, et al., Syntaxin 3, but not syntaxin 4, is required for mast cell-regulated exocytosis, where it plays a primary role mediating compound exocytosis. J Biol Chem. 2019 Mar 1;294(9):3012-3023

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory