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Treml4 Gene Detail
Summary
  • Symbol
    Treml4
  • Name
    triggering receptor expressed on myeloid cells-like 4
  • Synonyms
    5031403H21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923239
    NCBI Gene: 224840
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:48264295-48275360 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 23.99 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    146 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923239
protein coding gene Chr17:48264181-48275607 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023866
protein coding gene Chr17:49535218-49546817 (+)
A/J MGP_AJ_G0023826
protein coding gene Chr17:48241943-48253006 (+)
AKR/J MGP_AKRJ_G0023794
protein coding gene Chr17:48713597-48724659 (+)
BALB/cJ MGP_BALBcJ_G0023828
protein coding gene Chr17:48165870-48176936 (+)
C3H/HeJ MGP_C3HHeJ_G0023591
protein coding gene Chr17:49422596-49433658 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024271
protein coding gene Chr17:51641782-51652847 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021720
protein coding gene Chr17:45002790-45014023 (+)
CAST/EiJ MGP_CASTEiJ_G0023073
protein coding gene Chr17:49604514-49615685 (+)
CBA/J MGP_CBAJ_G0023567
protein coding gene Chr17:53484827-53495889 (+)
DBA/2J MGP_DBA2J_G0023696
protein coding gene Chr17:47009728-47020790 (+)
FVB/NJ MGP_FVBNJ_G0023662
protein coding gene Chr17:46669974-46681047 (+)
LP/J MGP_LPJ_G0023776
protein coding gene Chr17:50242751-50253823 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023690
protein coding gene Chr17:52983848-52994917 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024317
protein coding gene Chr17:49052414-49063484 (+)
PWK/PhJ MGP_PWKPhJ_G0022818
protein coding gene Chr17:46438266-46449351 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022632
protein coding gene Chr17:45950111-45961206 (+)
WSB/EiJ MGP_WSBEiJ_G0023137
protein coding gene Chr17:49641217-49652277 (+)



Homology
more
  • Human Ortholog
    TREML4, triggering receptor expressed on myeloid cells like 4
  • Human Ortholog
    TREML4, triggering receptor expressed on myeloid cells like 4
    Orthology source: HGNC
  • Synonyms
    TLT4, TLT-4
  • Links
    NCBI Gene ID: 285852
    neXtProt AC: NX_Q6UXN2
    UniProt: Q6UXN2

  • Chr Location
    6p21.1; chr6:41228292-41239386 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    6 phenotype references
Mice homozygous for a knock-out allele do not exhibit any significant alterations in the uptake and cross-presentation of dying cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000051682 Ensembl Gene Model | MGI Sequence Detail 11066 C57BL/6J ±  kb
transcript ENSMUST00000154335 Ensembl | MGI Sequence Detail 838 Not Applicable  
polypeptide ENSMUSP00000118772 Ensembl | MGI Sequence Detail 264 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 9
    cDNA 9

    Microarray probesets 2
Other
Accession IDs
less
MGI:2147108
References
more
  • Summaries
    All 27
    Gene Ontology 5
    Phenotypes 6
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:231858 Ramirez-Ortiz ZG, et al., The receptor TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunity. Nat Immunol. 2015 May;16(5):495-504

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory