About   Help   FAQ
Treml4 Gene Detail
Summary
  • Symbol
    Treml4
  • Name
    triggering receptor expressed on myeloid cells-like 4
  • Synonyms
    5031403H21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923239
    NCBI Gene: 224840
Location & Maps
more
  • Sequence Map
    Chr17:48264295-48275360 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      11066 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 23.99 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TREML4, triggering receptor expressed on myeloid cells like 4
  • Human Ortholog
    TREML4, triggering receptor expressed on myeloid cells like 4
    Orthology source: HGNC
  • Synonyms
    TLT4, TLT-4
  • Links
    NCBI Gene ID: 285852
    neXtProt AC: NX_Q6UXN2

  • Chr Location
    6p21.1; chr6:41228324-41238382 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    6 phenotype references
Mice homozygous for a knock-out allele do not exhibit any significant alterations in the uptake and cross-presentation of dying cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028419 VEGA Gene Model | MGI Sequence Detail 11066 C57BL/6J ±  kb
transcript OTTMUST00000070412 VEGA | MGI Sequence Detail 838 Not Applicable  
polypeptide OTTMUSP00000035881 VEGA | MGI Sequence Detail 264 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    146 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 8
    cDNA 8

    Microarray probesets 2
Other
Accession IDs
less
MGI:2147108
References
more
  • Summaries
    All 26
    Gene Ontology 3
    Phenotypes 6
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:231858 Ramirez-Ortiz ZG, et al., The receptor TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunity. Nat Immunol. 2015 May;16(5):495-504

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/20/2016
MGI 6.05
The Jackson Laboratory