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Dock11
Gene Detail
 Symbol
Name
ID
Dock11
dedicator of cytokinesis 11
MGI:1923224
Synonyms 5033414A21Rik, Zizimin2
Feature Type protein coding gene
Genetic Map
Chromosome X
20.35 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
ChrX:35888832-36076562 bp, + strand
From VEGA annotation of GRCm38

  187731 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:70950  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Dock11

Human
homologs
Human Homolog DOCK11, dedicator of cytokinesis 11
NCBI Gene ID 139818
neXtProt AC  NX_Q5JSL3
Human Synonyms  ACG, bB128O4.1, ZIZ2
Human Chr (Location)  Xq24; chrX:118495909-118686163 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Dock11 interacts with 198 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process positive regulation of Rho GTPase activity, small GTPase mediated signal transduction
Component cellular_component
Function guanyl-nucleotide exchange factor activity, Rho GTPase binding, ...
External Resources: FuncBase
Expression
cDNA source data(40)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(43) cDNA(43)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000017193 (Evidence)
Ensembl Gene ModelENSMUSG00000031093 (Evidence)
Entrez Gene75974 (Evidence)
UniGene32873
DFCITC1582637, TC1591175
DoTSDT.530773, DT.87059686
NIA Mouse Gene IndexU081915
Consensus CDS ProjectCCDS40923.1
International Mouse Knockout Project StatusDock11
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017193 VEGA Gene Model | MGI Sequence Detail 187731 C57BL/6J ±  kb
transcript OTTMUST00000041633 VEGA | MGI Sequence Detail 6665 Not Applicable 
polypeptide OTTMUSP00000018699 VEGA | MGI Sequence Detail 2073 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(9) UniProt(3)
Polymorphisms SNPs within 2kb(370 from dbSNP Build 137)    SNPs within 2kb including multiple locations(376)
Protein-related
information
ResourceIDDescription
InterPro IPR016024 Armadillo-type fold
InterPro IPR026791 Dedicator of cytokinesis
InterPro IPR021816 Dedicator of cytokinesis C/D, N-terminal
InterPro IPR010703 Dedicator of cytokinesis C-terminal
InterPro IPR027007 DHR-1 domain
InterPro IPR027357 DHR-2 domain
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
Protein Ontology PR:000006618 dedicator of cytokinesis protein 11
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(26)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory