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Vmp1 Gene Detail
Summary
  • Symbol
    Vmp1
  • Name
    vacuole membrane protein 1
  • Synonyms
    3110098I04Rik, 4930579A11Rik, Tango5, Tmem49
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923159
    NCBI Gene: 75909
  • Gene Overview
    MyGene.info: VMP1
  • Alliance
  • Transcription Start Sites
    27 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:86583854-86683822 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 51.82 cM, cytoband C
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    332 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923159
protein coding gene Chr11:86583854-86683836 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018892
protein coding gene Chr11:88154240-88258056 (-)
A/J MGP_AJ_G0018859
protein coding gene Chr11:84761868-84862485 (-)
AKR/J MGP_AKRJ_G0018829
protein coding gene Chr11:87299496-87403209 (-)
BALB/cJ MGP_BALBcJ_G0018832
protein coding gene Chr11:85145284-85245318 (-)
C3H/HeJ MGP_C3HHeJ_G0018646
protein coding gene Chr11:87322070-87424962 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019284
protein coding gene Chr11:90814574-90917848 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016917
protein coding gene Chr11:81784439-81883454 (-)
CAST/EiJ MGP_CASTEiJ_G0018201
protein coding gene Chr11:88010349-88117568 (-)
CBA/J MGP_CBAJ_G0018617
protein coding gene Chr11:94636004-94744549 (-)
DBA/2J MGP_DBA2J_G0018725
protein coding gene Chr11:84331085-84432593 (-)
FVB/NJ MGP_FVBNJ_G0018714
protein coding gene Chr11:83833162-83933625 (-)
LP/J MGP_LPJ_G0018795
protein coding gene Chr11:88640246-88745763 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018741
protein coding gene Chr11:94736526-94847692 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019324
protein coding gene Chr11:87543322-87645989 (-)
PWK/PhJ MGP_PWKPhJ_G0017970
protein coding gene Chr11:85125059-85228803 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017762
protein coding gene Chr11:87097581-87200608 (-)
WSB/EiJ MGP_WSBEiJ_G0018252
protein coding gene Chr11:87413179-87517182 (-)



Homology
more
  • Human Ortholog
    VMP1, vacuole membrane protein 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    VMP1, vacuole membrane protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EPG3, TANGO5, TMEM49
  • Links
    NCBI Gene ID: 81671
    neXtProt AC: NX_Q96GC9
    UniProt: Q96GC9

  • Chr Location
    17q23.1; chr17:59707502-59840593 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 75909 NCBI Gene Model | MGI Sequence Detail 99969 C57BL/6J ±  kb
transcript NM_029478 RefSeq | MGI Sequence Detail 2554 C57BL/6  
polypeptide Q99KU0 UniProt | EBI | MGI Sequence Detail 406 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 15

    Microarray probesets 4
Other
Accession IDs
less
MGI:1925760, MGI:2144264
References
more
  • Summaries
    All 46
    Gene Ontology 8
    Phenotypes 15
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:251891 Zhao YG, et al., The ER-Localized Transmembrane Protein EPG-3/VMP1 Regulates SERCA Activity to Control ER-Isolation Membrane Contacts for Autophagosome Formation. Mol Cell. 2017 Sep 21;67(6):974-989.e6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory