About   Help   FAQ
Dcp1a Gene Detail
Summary
  • Symbol
    Dcp1a
  • Name
    decapping mRNA 1A
  • Synonyms
    1110066A22Rik, 4930568L04Rik, D14Ertd817e, Mitc1, SMIF
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923151
    NCBI Gene: 75901
  • Gene Overview
    MyGene.info: DCP1A
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:30201492-30249020 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 18.75 cM, cytoband B
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    276 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923151
protein coding gene Chr14:30201443-30249020 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021103
protein coding gene Chr14:23605739-23653215 (+)
A/J MGP_AJ_G0021051
protein coding gene Chr14:22726863-22774532 (+)
AKR/J MGP_AKRJ_G0021028
protein coding gene Chr14:23832652-23880217 (+)
BALB/cJ MGP_BALBcJ_G0021055
protein coding gene Chr14:22820169-22868272 (+)
C3H/HeJ MGP_C3HHeJ_G0020838
protein coding gene Chr14:23687960-23736140 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021487
protein coding gene Chr14:24542434-24589892 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019050
protein coding gene Chr14:22793075-22839163 (+)
CAST/EiJ MGP_CASTEiJ_G0020363
protein coding gene Chr14:23426599-23475739 (+)
CBA/J MGP_CBAJ_G0020805
protein coding gene Chr14:25492545-25540350 (+)
DBA/2J MGP_DBA2J_G0020927
protein coding gene Chr14:22759650-22807131 (+)
FVB/NJ MGP_FVBNJ_G0020911
protein coding gene Chr14:22716053-22764244 (+)
LP/J MGP_LPJ_G0020996
protein coding gene Chr14:23927065-23974548 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020937
protein coding gene Chr14:24769337-24816903 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021520
protein coding gene Chr14:23576276-23623833 (+)
PWK/PhJ MGP_PWKPhJ_G0020111
protein coding gene Chr14:22189987-22239255 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019935
protein coding gene Chr14:23166252-23221583 (+)
WSB/EiJ MGP_WSBEiJ_G0020418
protein coding gene Chr14:23640582-23689617 (+)



Homology
more
  • Human Ortholog
    DCP1A, decapping mRNA 1A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DCP1A, decapping mRNA 1A
  • Synonyms
    HSA275986, Nbla00360, SMAD4IP1, SMIF
  • Links
    NCBI Gene ID: 55802
    neXtProt AC: NX_Q9NPI6
    UniProt: Q9NPI6

  • Chr Location
    3p21.1; chr3:53283423-53347627 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit embryonic growth retardation and die around E10.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021962 Ensembl Gene Model | MGI Sequence Detail 47529 C57BL/6J ±  kb
    transcript ENSMUST00000022535 Ensembl | MGI Sequence Detail 5576 Not Applicable  
    polypeptide ENSMUSP00000022535 Ensembl | MGI Sequence Detail 602 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 122
      cDNA 120
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1289310, MGI:1916184, MGI:2145732
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 18
      Gene Ontology 10
      Phenotypes 6
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:305571 Ibayashi M, et al., mRNA decapping factor Dcp1a is essential for embryonic growth in mice. Biochem Biophys Res Commun. 2021 May 28;555:128-133

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    10/05/2021
    MGI 6.17
    The Jackson Laboratory