About   Help   FAQ
Daw1 Gene Detail
Summary
  • Symbol
    Daw1
  • Name
    dynein assembly factor with WDR repeat domains 1
  • Synonyms
    4930563E19Rik, 4933429D11Rik, b2b1116Clo, b2b1584Clo, Wdr69
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923089
    NCBI Gene: 71227
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:83159752-83210574 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 42.70 cM, cytoband C5
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    287 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923089
protein coding gene Chr1:83159742-83210577 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016224
protein coding gene Chr1:84128298-84183398 (+)
A/J MGP_AJ_G0016207
protein coding gene Chr1:81135714-81190189 (+)
AKR/J MGP_AKRJ_G0016164
protein coding gene Chr1:83342082-83400629 (+)
BALB/cJ MGP_BALBcJ_G0016162
protein coding gene Chr1:81285760-81336345 (+)
C3H/HeJ MGP_C3HHeJ_G0015992
protein coding gene Chr1:83722855-83775303 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016615
protein coding gene Chr1:87376852-87443386 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014335
protein coding gene Chr1:76328243-76378044 (+)
CAST/EiJ MGP_CASTEiJ_G0015577
protein coding gene Chr1:83159039-83220063 (+)
CBA/J MGP_CBAJ_G0015966
protein coding gene Chr1:90177481-90233467 (+)
DBA/2J MGP_DBA2J_G0016067
protein coding gene Chr1:80404288-80455509 (+)
FVB/NJ MGP_FVBNJ_G0016070
protein coding gene Chr1:79522308-79571991 (+)
LP/J MGP_LPJ_G0016140
protein coding gene Chr1:85239172-85294604 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016090
protein coding gene Chr1:93531841-93590151 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016662
protein coding gene Chr1:83524457-83575354 (+)
PWK/PhJ MGP_PWKPhJ_G0015363
protein coding gene Chr1:79862481-79916007 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015141
protein coding gene Chr1:82713414-82769099 (+)
WSB/EiJ MGP_WSBEiJ_G0015638
protein coding gene Chr1:83311002-83364284 (+)



Homology
more
  • Human Ortholog
    DAW1, dynein assembly factor with WD repeats 1
  • Human Ortholog
    DAW1, dynein assembly factor with WD repeats 1
    Orthology source: HGNC
  • Synonyms
    ODA16, WDR69
  • Links
    NCBI Gene ID: 164781
    neXtProt AC: NX_Q8N136
    UniProt: Q8N136

  • Chr Location
    2q36.3; chr2:227871054-227924347 (+)  GRCh38.p7

  • HCOP
    human homology predictions: DAW1
  • Gene Tree
Human Diseases
more
  • Diseases
    3 with Daw1 mouse models

Human Disease Mouse Models
      
IDs
View 2 models
IDs
View 2 models
IDs
View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 2 alleles in 2 genetic backgrounds
    41 images
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Chemically induced (ENU)
    2
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Genomic Mutations
    2 involving Daw1
  • Incidental Mutations
    APF , CvDC
  • Find Mice (IMSR)
Mice homozygous for an induced mutation exhibit dextrocardia associated with situs inversus totalis, overriding aorta, ventricular septal defects, and dual inferior vena cava as well as dextrogastria, hypoplastic spleen, inverted liver, lung lobation/isomerism and dyskinetic/immotile airway cilia
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000053161 Ensembl Gene Model | MGI Sequence Detail 50823 C57BL/6J ±  kb
transcript ENSMUST00000065403 Ensembl | MGI Sequence Detail 1651 Not Applicable  
polypeptide ENSMUSP00000067583 Ensembl | MGI Sequence Detail 415 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    6 Sequences
  • InterPro Domains
    IPR020472 G-protein beta WD-40 repeat
    IPR001680 WD40 repeat
    IPR019775 WD40 repeat, conserved site
    IPR017986 WD40-repeat-containing domain
    IPR036322 WD40-repeat-containing domain superfamily
    IPR015943 WD40/YVTN repeat-like-containing domain superfamily
Molecular
Reagents
less
  • All nucleic 8
    Genomic 1
    cDNA 7

    Microarray probesets 2
Other
Accession IDs
less
MGI:1918477, MGI:5311348, MGI:5431490
References
more
  • Summaries
    All 23
    Diseases 1
    Gene Ontology 2
    Phenotypes 7
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:264151 Solomon GM, et al., Assessment of ciliary phenotype in primary ciliary dyskinesia by micro-optical coherence tomography. JCI Insight. 2017 Mar 9;2(5):e91702

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/03/2019
MGI 6.14
The Jackson Laboratory