About   Help   FAQ
Hormad2
Gene Detail
 Symbol
Name
ID
Hormad2
HORMA domain containing 2
MGI:1923078
Synonyms 4930529M09Rik
Feature Type protein coding gene
Genetic Map
Chromosome 11
2.94 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:4345814-4441105 bp, - strand
From VEGA annotation of GRCm38

  95292 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:45130  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken

Protein SuperFamily: conserved protein with HORMA-domain
Gene Tree: Hormad2

Human
homologs
Human Homolog HORMAD2, HORMA domain containing 2
NCBI Gene ID 150280
neXtProt AC  NX_Q8N7B1
Human Synonyms  CT46.2
Human Chr (Location)  22q12.2; chr22:30080208-30177073 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(19) : Gene trapped(13) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous inactivation of this gene leads to arrest of spermatogenesis, male infertility, and abnormalities in male and female meiosis.
 
Interactions
Hormad2 interacts with 279 markers (Mir7-2, Mir7b, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process meiotic nuclear division, meiotic sister chromatid cohesion
Component chromosome, nucleus
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
cDNA source data(4)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(5) cDNA(4) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000005064 (Evidence)
Ensembl Gene ModelENSMUSG00000020419 (Evidence)
Entrez Gene75828 (Evidence)
UniGene159592
DFCITC1592528, TC1705446
DoTSDT.60102351, DT.87043235
NIA Mouse Gene IndexU032446
Consensus CDS ProjectCCDS36096.1
International Mouse Knockout Project StatusHormad2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005064 VEGA Gene Model | MGI Sequence Detail 95292 C57BL/6J ±  kb
transcript OTTMUST00000011281 VEGA | MGI Sequence Detail 1969 Not Applicable 
polypeptide OTTMUSP00000005254 VEGA | MGI Sequence Detail 306 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(18) UniProt(3)
Polymorphisms SNPs within 2kb(234 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003511 DNA-binding HORMA
Protein Ontology PR:000031503 HORMA domain-containing protein 2
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:192634 Kogo H, et al., HORMAD2 is essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Genes Cells. 2012 Nov;17(11):897-912
All references(34)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/19/2014
MGI 5.19
The Jackson Laboratory