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Hormad2
Gene Detail
Symbol

Name
ID
Hormad2
HORMA domain containing 2
MGI:1923078
Synonyms
4930529M09Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 11
2.94 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:4345814-4441105 bp, - strand
From VEGA annotation of GRCm38

  95292 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:45130  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken

HCOP human homology predictions: HORMAD2
Protein SuperFamily: conserved protein with HORMA-domain
Gene Tree: Hormad2

Human
homologs
HORMAD2, HORMA domain containing 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 150280
neXtProt AC: NX_Q8N7B1

Human Synonyms: CT46.2

Human Chr (Location): 22q12.2; chr22:30080069-30210882 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(19) : Gene trapped(13) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous inactivation of this gene leads to arrest of spermatogenesis, male infertility, and abnormalities in male and female meiosis.
 
Interactions
Hormad2 interacts with 279 markers (Mir7-2, Mir7b, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process meiotic cell cycle, meiotic sister chromatid cohesion
Component chromosome, nucleus, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
cDNA source data(4)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(5) cDNA(4) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000005064 (Evidence)
Ensembl Gene Model ENSMUSG00000020419 (Evidence)
Entrez Gene 75828 (Evidence)
UniGene 159592
DFCI TC1592528, TC1705446
DoTS DT.60102351, DT.87043235
NIA Mouse Gene Index U032446
Consensus CDS Project CCDS36096.1
International Mouse Phenotyping Consortium Status Hormad2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005064 VEGA Gene Model | MGI Sequence Detail 95292 C57BL/6J ±  kb
transcript OTTMUST00000011281 VEGA | MGI Sequence Detail 1969 Not Applicable 
polypeptide OTTMUSP00000005254 VEGA | MGI Sequence Detail 306 Not Applicable 

For the selected sequences
All sequences(66) RefSeq(32) UniProt(3)
Polymorphisms
SNPs within 2kb(234 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003511 HORMA domain
Protein Ontology PR:000031503 HORMA domain-containing protein 2
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:199766 Jordan PW, et al., Polo-like kinase is required for synaptonemal complex disassembly and phosphorylation in mouse spermatocytes. J Cell Sci. 2012 Nov 1;125(Pt 21):5061-72
All references(34)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory