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Tasp1
Gene Detail
Symbol

Name
ID
Tasp1
taspase, threonine aspartase 1
MGI:1923062
Synonyms
4930485D02Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 2
69.20 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:139833480-140066805 bp, - strand
From VEGA annotation of GRCm38

  233326 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9795  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TASP1
Gene Tree: Tasp1

Human
homologs
TASP1, taspase, threonine aspartase, 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 55617
neXtProt AC: NX_Q9H6P5

Human Synonyms: C20orf13, dJ585I14.2

Human Chr (Location): 20p12.1; chr20:13389389-13638936 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(19) : Gene trapped(15) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele display prenatal and early postnatal lethality, reduced body size, impaired suckling behavior, homeotic transformations of the axial skeleton, and cell cycle defects.
 
Interactions
Tasp1 interacts with 219 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process positive regulation of transcription, DNA-templated, proteolysis
Function hydrolase activity, peptidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(30)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase tasp1    NEW 
Molecular
reagents
All nucleic(30) cDNA(30)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000015577 (Evidence)
Ensembl Gene Model ENSMUSG00000039033 (Evidence)
Entrez Gene 75812 (Evidence)
UniGene 293449
DFCI TC1775900, TC1773686, TC1682311, TC1585343, TC1582027
DoTS DT.87035918, DT.97409424, DT.55243518, DT.485784, DT.91580920, DT.101227560, DT.101363007, DT.101190364
NIA Mouse Gene Index U023417
EC 3.4.25.-
Consensus CDS Project CCDS16802.1, CCDS50731.1
International Mouse Phenotyping Consortium Status Tasp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015577 VEGA Gene Model | MGI Sequence Detail 233326 C57BL/6J ±  kb
transcript OTTMUST00000037007 VEGA | MGI Sequence Detail 2258 Not Applicable 
polypeptide OTTMUSP00000016604 VEGA | MGI Sequence Detail 420 Not Applicable 

For the selected sequences
All sequences(76) RefSeq(31) UniProt(2)
Polymorphisms
SNPs within 2kb(1619 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1625)
Protein-related
information
ResourceIDDescription
InterPro IPR000246 Peptidase T2, asparaginase 2
Protein Ontology PR:000016088 threonine aspartase 1
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:220544 Takeda S, et al., Taspase1-dependent TFIIA cleavage coordinates head morphogenesis by limiting Cdkn2a locus transcription. J Clin Invest. 2015 Mar 2;125(3):1203-14
All references(37)
Other
accession IDs
MGI:2139420

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory