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4930447C04Rik Gene Detail
Summary
  • Symbol
    4930447C04Rik
  • Name
    RIKEN cDNA 4930447C04 gene
  • Synonyms
    4921504I02Rik, A930035O15Rik, Six6as, Six6os1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923051
    NCBI Gene: 75801
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:72880193-72917957 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 30.30 cM, cytoband C3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    194 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923051
protein coding gene Chr12:72880193-72940774 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019830
protein coding gene Chr12:72741585-72808053 (-)
A/J MGP_AJ_G0019788
protein coding gene Chr12:70036049-70098798 (-)
AKR/J MGP_AKRJ_G0019763
protein coding gene Chr12:72156176-72218659 (-)
BALB/cJ MGP_BALBcJ_G0019768
protein coding gene Chr12:70511532-70574056 (-)
C3H/HeJ MGP_C3HHeJ_G0019573
protein coding gene Chr12:72583403-72646848 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020220
protein coding gene Chr12:75013809-75078980 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017838
protein coding gene Chr12:67492230-67553108 (-)
CAST/EiJ MGP_CASTEiJ_G0019125
protein coding gene Chr12:67367421-67435835 (-)
CBA/J MGP_CBAJ_G0019543
protein coding gene Chr12:77844058-77919032 (-)
DBA/2J MGP_DBA2J_G0019659
protein coding gene Chr12:69921333-69983739 (-)
FVB/NJ MGP_FVBNJ_G0019646
protein coding gene Chr12:68784555-68844240 (-)
LP/J MGP_LPJ_G0019731
protein coding gene Chr12:72778371-72837306 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019685
protein coding gene Chr12:81020538-81093255 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020255
protein coding gene Chr12:71630156-71694743 (-)
PWK/PhJ MGP_PWKPhJ_G0018890
protein coding gene Chr12:64230134-64295181 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018685
protein coding gene Chr12:66039087-66108940 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    C14orf39, chromosome 14 open reading frame 39
  • Vertebrate Orthologs
    9
  • Human Ortholog
    C14orf39, chromosome 14 open reading frame 39
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Six6os1
  • Links
    NCBI Gene ID: 317761
    neXtProt AC: NX_Q8N1H7
    UniProt: Q8N1H7

  • Chr Location
    14q23.1; chr14:60435954-60499773 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display male and female infertility with meiotic arrest and defective synaptic formation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 75801 NCBI Gene Model | MGI Sequence Detail 37765 C57BL/6J ±  kb
    transcript NM_029444 RefSeq | MGI Sequence Detail 1910 C57BL/6  
    polypeptide Q9CTN5 UniProt | EBI | MGI Sequence Detail 574 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • InterPro Domains
      IPR031380 Six6 opposite strand transcript 1
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 16
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1921603, MGI:1925081
    References
    more
    • Summaries
      All 27
      Developmental Gene Expression 3
      Gene Ontology 3
      Phenotypes 6
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:238491 Gomez-H L, et al., C14ORF39/SIX6OS1 is a constituent of the synaptonemal complex and is essential for mouse fertility. Nat Commun. 2016 Oct 31;7:13298

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory