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Pnpla5 Gene Detail
Summary
  • Symbol
    Pnpla5
  • Name
    patatin-like phospholipase domain containing 5
  • Synonyms
    4833426H19Rik, GS2L
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923022
    NCBI Gene: 75772
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:84112356-84123175 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 39.78 cM, cytoband E3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    114 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923022
protein coding gene Chr15:84112356-84123366 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022173
protein coding gene Chr15:84861511-84873598 (-)
A/J MGP_AJ_G0022132
protein coding gene Chr15:81745363-81756569 (-)
AKR/J MGP_AKRJ_G0022107
protein coding gene Chr15:84127723-84138515 (-)
BALB/cJ MGP_BALBcJ_G0022138
protein coding gene Chr15:81886465-81897559 (-)
C3H/HeJ MGP_C3HHeJ_G0021908
protein coding gene Chr15:84080848-84091384 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022583
protein coding gene Chr15:88110701-88122603 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020108
protein coding gene Chr15:78111893-78122897 (-)
CAST/EiJ MGP_CASTEiJ_G0021430
protein coding gene Chr15:84867407-84877938 (-)
CBA/J MGP_CBAJ_G0021875
protein coding gene Chr15:90940676-90954832 (-)
DBA/2J MGP_DBA2J_G0022002
protein coding gene Chr15:81229193-81239873 (-)
FVB/NJ MGP_FVBNJ_G0021981
protein coding gene Chr15:80283652-80294205 (-)
LP/J MGP_LPJ_G0022073
protein coding gene Chr15:85030572-85044133 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022001
protein coding gene Chr15:95777820-95790512 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022598
protein coding gene Chr15:84132615-84144323 (-)
PWK/PhJ MGP_PWKPhJ_G0021171
protein coding gene Chr15:81221537-81232608 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021005
protein coding gene Chr15:83845894-83856397 (-)
WSB/EiJ MGP_WSBEiJ_G0021479
protein coding gene Chr15:84633499-84645345 (-)



Homology
more
  • Human Ortholog
    PNPLA5, patatin like phospholipase domain containing 5
  • Vertebrate Orthologs
    7
  • Human Ortholog
    PNPLA5, patatin like phospholipase domain containing 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    dJ388M5, dJ388M5.4, GS2L
  • Links
    NCBI Gene ID: 150379
    neXtProt AC: NX_Q7Z6Z6
    UniProt: Q7Z6Z6

  • Chr Location
    22q13.31; chr22:43879678-43892013 (-)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000018868 Ensembl Gene Model | MGI Sequence Detail 10820 C57BL/6J ±  kb
transcript ENSMUST00000230566 Ensembl | MGI Sequence Detail 2172 Not Applicable  
polypeptide ENSMUSP00000155268 Ensembl | MGI Sequence Detail 433 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000012945 patatin-like phospholipase domain-containing protein 5
  • EC
  • InterPro Domains
    IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase
    IPR002641 Patatin-like phospholipase domain
    IPR033562 Patatin-like phospholipase domain-containing protein
Molecular
Reagents
less
  • All nucleic 6
    cDNA 6

    Microarray probesets 2
References
more
  • Summaries
    All 43
    Diseases 1
    Gene Ontology 5
    Phenotypes 20
  • Earliest
    J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
  • Latest
    J:233611 Hirata A, et al., Homeobox family Hoxc localization during murine palate formation. Congenit Anom (Kyoto). 2016 Jul;56(4):172-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory